PLCB1
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Official Full Name
Plcb1 phospholipase C, beta 1 -
Synonyms
PLCB1;phospholipase C, beta 1;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1;PLC-154;PLC-beta-1;phospholipase C-beta-1;phospholipase C-beta-1a;phosphoinositide phospholipase C;phosphoinositide phospholipase C-beta-1;1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1;Plcb;AI132408;mKIAA0581;3110043I21Rik
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
PLCB1 involved in several pathways and played different roles in them. We selected most pathways PLCB1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | GPX8,ATP1B4,PAX8,TG,ATF4,DUOXA2,CREB3L1,TTF2,GPX1,GPX6 |
| Vascular smooth muscle contraction | GNA12,PRKACA,ADCY1A,PRKACBB,GNA15.1,NPR2,PLA2G10,PPP1CB,PLA2G5,PPP1CA |
| Inositol phosphate metabolism | IPPK,MTMR1A,SYNJ2,PIK3CB,PIP5KL1,NUDT10,PIP5K1B,MTMR7A,NUDT3A,PIP4K2A |
| Pathways in cancer | GLI1,ITGA2B,FZD1,SPI1,PDGFRB,FGFR2,NFKB1,RXRG,ARHGEF12,NOS2 |
| Endocrine and other factor-regulated calcium reabsorption | PRKACB,ATP1B4,ATP1A2,PLCB4,PLCB2,KLK1B26,KLK1B1,GNAQ,ATP1A3,ATP1B2 |
| Sphingolipid signaling pathway | PPP2CA,SPTLC3,PRKCZ,GAB2,DEGS2,CERS2,FYN,KRAS,MAPK13,LASS4 |
| Chagas disease (American trypanosomiasis) | NFKBIA,PLCB4,CD3G,CCL3L3,C1QB,PIK3CG,C1QA,Il2,PIK3R2,MAPK1 |
| Insulin secretion | ADCYAP1,STX1A,GNAS,GNAQ,CREB3L1,INS,CAMK2B,CAMK2A,PRKACA,SLC2A1 |
| Gastric acid secretion | PRKACG,CA2,KCNJ10,CAMK2B,ATP1B1,PRKCG,ATP1B4,GNAI2,PLCB4,KCNK2 |
Protein Function
PLCB1 has several biochemical functions, for example, GTPase activator activity,calcium ion binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCB1 itself. We selected most functions PLCB1 had, and list some proteins which have the same functions with PLCB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | GNAL,GPR152,CXXC5,GNGT2,OLFCS1,OLFR510,MIER1A,PROKR1A,MUL1,STAT1A |
| lamin binding | PKP1,SUN1,SUN2,NARF,LBR,BNIP3L,PPP4C,TMPO,SYNE1,TMEM201 |
| calcium ion binding | CAPN2A,FSTL1B,PSPH,JAG2B,BGLAP-RS1,CUBN,CETN2,BGLAP2,PCDHB13,BMP1 |
| protein homodimerization activity | PVRL4,ENG,ZBTB16,FBXO4,IKBKB,RAB11FIP4B,CRYM,MAPK4,SRF,VWF |
| GTPase activator activity | RGS14,RGS12,HTR2B,RGS5,RIN3,ECT2,CDC42EP1B,TIAM2,ARHGAP32,RAB3GAP2 |
| calmodulin binding | SPATA17,KCNQ3,ATP2B4,GAP43,PHKG1B,SPHK1,EDF1,RASGRF2B,MYH3,UPF3B |
| phosphatidylinositol-4,5-bisphosphate binding | RAG2,TULP3,RS1,D6WSU116E,VIL1,Apba1,KCNQ1,SNX20,FAM123B,COMMD1 |
| protein binding | BLOC1S1,GYS1,PTPN9,TERT,TRIM11,GNG4,L3MBTL3,UNC119B,BLMH,PPP1R3C |
| phosphatidylinositol phospholipase C activity | CHRM1,C3AR1,CCR1,CCL5,PLCG2,PLCH2,PLCD1,PLCB3,PLCG1,CCKBR |
Interacting Protein
PLCB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCB1.
CTBP2;TFCP2;CTBP1;CTBP2;CEP76;SPTBN1
PLCB1 Related Signal Pathway
Resources
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References
- Ichishima, K; Yamamoto, S; et al. alpha(1)-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes. BRITISH JOURNAL OF PHARMACOLOGY 161:193-206(2010).
- Lo Vasco, VR; Fabrizi, C; et al. Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes. JOURNAL OF CELLULAR BIOCHEMISTRY 100:952-959(2007).
