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Official Full Name phospholipase D1, phosphatidylcholine-specific
Background Phospholipase D1 catalyzes the hydrolysis of PC to produce phosphatidic acid and choline and is implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May also be involved in the regulation of perinuclear intravesicular membrane traffic. Phospholipase D2 may have a role in signal induced cytoskeletal regulation and/or endocytosis. The mechanisms that regulate phospholipase D2 are not known.
Synonyms Phospholipase D1 and Phospholipase D2; PLD1; phospholipase D1, phosphatidylcholine-specific; phospholipase D1; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLD1-1770H Recombinant Human PLD1, GST-tagged E.coli GST
    Human PLD1-27923TH Recombinant Human PLD1, GST-tagged Wheat Germ GST
    Human PLD1-3123HCL Recombinant Human PLD1 293 Cell Lysate HEK293 N/A
    Rat PLD1-4509R Recombinant Rat PLD1 Protein Mammalian Cell His

    pld1 involved in several pathways and played different roles in them. We selected most pathways pld1 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with pld1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism AGPAT6; PLA2G10; PCYT2; CEPT1B; LCLAT1; CRLS1; PLD3; GPD1C; PLA2G4AA; PNPLA6
    Ether lipid metabolism PLA2G4B; PAFAH1B3; CEPT1B; PPAP2A; PLA2G10; PAFAH1B1B; PPAP2D; PLD1; PLA2G1B; LPCAT4
    Metabolic pathways HGSNAT; IMPA2; TPH1; ALG10B; CYP24A1; SDHDA; CYP2C70; MUT; ybaS; UOX
    Ras signaling pathway HGF; PTPN11; FLT1; FOXO4; ETS2; GAB1; FGF22; FGF4; ANGPT4; GRIN2B
    cAMP signaling pathway PPP1CC; HCAR2; GHRL; GNAI1; Adcy4; ATP1B2; RAP1B; GRIN3A; MAPK1; ARAP3
    Sphingolipid signaling pathway PIK3CD; SGMS1; RAC1; GAB2; PRKCG; SGPP1; PPP2R5A; PRKCB; PIK3R5; PTEN
    Phospholipase D signaling pathway PIP5K1B; AGPAT5; KIT; PLD1; LPAR5; AKT2; IL-8; LPAR3; PRKCA; FCER1G
    Endocytosis GRK1A; ARAP3; RAB11FIP3; ARPC1B; EHD1A; SH3GLB1; HLA-B; ADRB3; WASH1; RAB10
    Fc gamma R-mediated phagocytosis PRKCD; VASP; WASF2; FCGR3A; CFL1; SCIN; PLD2; PLA2G6; INPPL1; VAV2
    Glutamatergic synapse GRM7; GNAS; SLC17A7; GRM5; SLC17A8; ADRBK2; GNAI1; PPP3R1; PPP3CB; GRIA2
    GnRH signaling pathway PRKACBA; GNA15.1; PRKACA; PLA2G4AA; ELK1; GNA15.4; CDC42L; PRKACAA; GNRH1; ATF4
    Pathways in cancer EGLN1; LPAR5; BAD; PTCH2; PRKACA; LAMA3; APC2; CBLC; FGFR2; NFKB1
    Pancreatic cancer RAC2; AKT2; MAPK3; SMAD4; MAPK9; MAPK10; STAT1; RB1; PIK3CG; PIK3R1
    Choline metabolism in cancer PRKCG; DGKA; FOS; PDGFRB; DGKG; PIP5K1B; SLC22A3; SOS1; PLA2G4B; AKT1

    pld1 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidylinositol binding, phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by pld1 itself. We selected most functions pld1 had, and list some proteins which have the same functions with pld1. You can find most of the proteins on our site.

    Function Related Protein
    N-acylphosphatidylethanolamine-specific phospholipase D activity PLD3; PLD4; PLD1; PLD2; NAPEPLD
    phosphatidylinositol binding PASK; SNX12; SNX29; SNX1B; NISCH; SNX18A; PLD1; SNX33; NOXO1; PIK3C2B
    phospholipase D activity HMOX1; PLD2; PLD1; PLD3; PLD4; PLD1A; GPLD1
    protein binding CMTM2A; MEN1; CBX6; LYVE1; LAMTOR1; SFRP5; IFIT2; PBX2; FAF2; COL3A1

    pld1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pld1 here. Most of them are supplied by our site. Hope this information will be useful for your research of pld1.

    CFL1; PKN3; prkC; PLCG1; STXBP1

    Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).
    Alexandrescu, S; Tatevian, N; et al. Morphoproteomics provides support for TGF-beta pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 5:503-511(2012).

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