PLK1
-
Official Full Name
polo-like kinase 1
-
Overview
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. -
Synonyms
PLK1; polo-like kinase 1; PLK; STPK13; serine/threonine-protein kinase PLK1; PLK-1; polo like kinase; polo (Drosophia)-like kinase; serine/threonine-protein kinase 13; cell cycle regulated protein kinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PLK1 involved in several pathways and played different roles in them. We selected most pathways PLK1 participated on our site, such as FoxO signaling pathway, Cell cycle, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | INS1;FOXO1B;IGF1;INSRA;SMAD3A;PRKAB2;S1PR1;PIK3R3;G6PC2 |
| Cell cycle | KNTC1;CEP164;NCAPG2;CDCA5;SMC2;CKS1B;LIN9;SYCP2;CCND2A |
| Oocyte meiosis | PPP2CB;PPP3CC;CALM3B;ANAPC13;ADCY1A;YWHAH;CAMK2D2;ANAPC7;CDK1 |
| Progesterone-mediated oocyte maturation | MAPK8B;CCNB3;INS;AKT2L;CPEB1A;CPEB3;PRKACA;PRKACB;RAF1A |
PLK1 has several biochemical functions, for example, ATP binding, anaphase-promoting complex binding, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLK1 itself. We selected most functions PLK1 had, and list some proteins which have the same functions with PLK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCA6;IKBKE;PIK3C2G;PSMC1A;DNAJA4;NUBP2;STK24B;PRKCBB;PDPK1B |
| anaphase-promoting complex binding | CLSPN;PTEN;PLK1 |
| kinase activity | SNRKA;PDK2B;WNK2;UCKL1A;DGKAA;EPHA4A;LRGUK;PIP5K1AA;PKN2 |
| microtubule binding | RACGAP1;PRC1B;KATNB1;KIF5B;FES;KIF3C;REEP4;PAFAH1B1A;KIF25 |
| protein binding | PDGFRA;EIF4EBP2;DSCAM;SOX17;UXT;PKD1L3;SPATA7;CRYAB;FAM71C |
| protein kinase activity | TESK2;CSNK1G2A;GSK3AA;ANKK1;STK25A;CDK9;KITA;STK4;IGF1RB |
| protein kinase binding | GDF3;TP53;ATP1A1;CCND1;LIMS1;TRIB3;STK11IP;CCNL1B;NSF |
| protein serine/threonine kinase activity | PLK3;STK35;DSTYK;SIK2A;MINK1;MAPK6;PKZ;NEK9;PAK3 |
PLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLK1.
TP53; SLX4; FADD
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewthe manufacturer's dedication to continuous improvement and innovation is evident in their ongoing efforts to enhance the PLK1 protein's performance and optimize its applications.
The exceptional quality and reliability of the PLK1 protein provided by the manufacturer cannot be overstated.
Its purity and consistency guarantee accurate and consistent results, allowing for confident data interpretation and analysis.
Q&As (5)
Ask a questionPLK1 inhibitors can be combined with chemotherapy or radiation therapy to enhance their effectiveness in treating certain types of cancer.
PLK1 inhibitors are being investigated as potential cancer therapies to target and inhibit the overactive PLK1 in cancer cells.
PLK1 inhibitors have shown promise in clinical trials for various cancer types, including breast, lung, and colorectal cancers.
This is a significant challenge, and researchers are working on developing selective inhibitors that primarily target cancer cells.
PLK1 levels can be elevated in some cancers, and its expression can be used as a diagnostic or prognostic biomarker.
Ask a Question for All PLK1 Products
Required fields are marked with *
My Review for All PLK1 Products
Required fields are marked with *
