PLP1
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Official Full Name
Proteolipid Protein 1
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Overview
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central;nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in;oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease;and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having;different 5 UTRs, have been identified for this gene. -
Synonyms
PLP1; PMD; HLD1; MMPL; SPG2; PLP/DM20; PLP; proteolipid protein 1; myelin proteolipid protein; lipophilin; OTTHUMP00000023761; OTTHUMP00000023762; major myelin proteolipid protein; spastic paraplegia 2, uncomplicated;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Taeniopygia guttata (Zebra finch) (Poephila guttata)
- E. coli
- E.coli
- E.coli expression system
- HEK293
- In vitro E. coli expression system
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- N
- GST
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PLP1-3099HCL | Recombinant Human PLP1 293 Cell Lysate | HEK293 | N/A |
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| Human | PLP1-2728H | Recombinant Human PLP1 Full Length Transmembrane protein (2-277 aa), His-tagged | In vitro E. coli expression system | His | 2-277aa |
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| Human | PLP1-10H | Recombinant Human PLP1 Protein, His-tagged | E. coli | His | Leu129~Phe242 |
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| Human | PLP1-1950H | Recombinant Human PLP1 Protein, His&GST-tagged | E.coli | N-His&GST | Leu129-Phe242 |
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| Mouse | PLP1-12987M | Recombinant Mouse PLP1 Protein | Mammalian Cell | His |
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| Mouse | PLP1-6858M | Recombinant Mouse PLP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | PLP1-6858M-B | Recombinant Mouse PLP1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | PLP1-4531R | Recombinant Rat PLP1 Protein | Mammalian Cell | His |
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| Rat | PLP1-4191R-B | Recombinant Rat PLP1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | PLP1-4191R | Recombinant Rat PLP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Bos taurus (Bovine) | RFL5124BF | Recombinant Full Length Bovine Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Canis lupus familiaris (Dog) (Canis familiaris) | RFL8825CF | Recombinant Full Length Dog Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Gallus gallus (Chicken) | RFL34498GF | Recombinant Full Length Chicken Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Homo sapiens (Human) | RFL22622HF | Recombinant Full Length Human Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277aa) |
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| Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) | RFL16964MF | Recombinant Full Length Macaca Fascicularis Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Mus musculus (Mouse) | RFL28004MF | Recombinant Full Length Mouse Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Oryctolagus cuniculus (Rabbit) | RFL28104OF | Recombinant Full Length Rabbit Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL20519PF | Recombinant Full Length Pongo Abelii Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Rattus norvegicus (Rat) | RFL24943RF | Recombinant Full Length Rat Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Rhesus Macaque | PLP1-3475R | Recombinant Rhesus monkey PLP1 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | PLP1-3293R | Recombinant Rhesus Macaque PLP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | PLP1-3293R-B | Recombinant Rhesus Macaque PLP1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Sus scrofa (Pig) | RFL32698SF | Recombinant Full Length Pig Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Taeniopygia guttata (Zebra finch) (Poephila guttata) | RFL12501TF | Recombinant Full Length Taeniopygia Guttata Myelin Proteolipid Protein(Plp1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-277) |
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| Chicken | PLP1-6829C | Recombinant Chicken PLP1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PLP1 Related Articles
PLP1 involved in several pathways and played different roles in them. We selected most pathways PLP1 participated on our site, such as Glial Cell Differentiation, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glial Cell Differentiation | PLP1;GAP43;TPPP;MBP;CNP |
| SIDS Susceptibility Pathways | RUNX3;EN1;YBX1;CDCA7L;CHRFAM7A;SST;CC2D1A;TAC1;IL1RN |
PLP1 has several biochemical functions, for example, protein binding, structural constituent of myelin sheath, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLP1 itself. We selected most functions PLP1 had, and list some proteins which have the same functions with PLP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | XRCC2;SKAP1;EIF4E;GNB2L1;VEGFAB;ADAMTSL4;TEN1;SLC25A18;JAGN1 |
| structural constituent of myelin sheath | MAL;MOBP;PLP1;MBP;MBPB;NCMAP |
| structural molecule activity | DESMA;EPB41L1;CLDN5A;CLDN22;CLDNE;JUP;JUPA;CYT1;COPB2 |
PLP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLP1.
PTPRN; AKT1; PTPRN; HTT
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