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PNKP

  • Official Full Name

    polynucleotide kinase 3-phosphatase

  • Overview

    This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5 phosphorylation and 3 dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
  • Synonyms

    PNKP; polynucleotide kinase 3-phosphatase; bifunctional polynucleotide phosphatase/kinase; PNK; 2(3)-polynucleotidase; DEM 1; DEM1; DNA 5 kinase/3 phosphatase; DNA 5-kinase/3-phosphatase; PNK 1; PNK1; PNKP_HUMAN; Polynucleotide 5 hydroxyl kinase; Polynucleotide 5-hydroxyl-kinase; Polynucleotide kinase 3 prime phosphatase; Polynucleotide kinase 3 phosphatase; Polynucleotide kinase 3-prime-phosphatase; Polynucleotide Kinase; Polynucleotide kinase-3-phosphatase; Homo sapiens polynucleotide kinase 3-phosphatase (PNKP); MCSZ; EIEE10;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PNKP-1385HCL Recombinant Human PNKP cell lysate N/A
Human PNKP-2145H Recombinant Human PNKP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PNKP-1109H Recombinant Human PNKP Protein (1-521 aa), His-SUMO-tagged E.coli His/SUMO 1-521 aa
Human PNKP-3964H Recombinant Human PNKP protein, His-tagged E.coli His 171-521 aa
Mouse Pnkp-4963M Recombinant Mouse Pnkp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish PNKP-4787Z Recombinant Zebrafish PNKP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PNKP Related Articles

PNKP involved in several pathways and played different roles in them. We selected most pathways PNKP participated on our site, such as APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway, Base Excision Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNKP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision RepairFEN1;TDG;POLD2;MBD4;XRCC1;PARP2;SMUG1;POLE;LIG3
DNA RepairCOPS4;POLD3;PARP1;ZNF830;USP43A;CLSPN;RNF4;ASCC1;THRSP
Resolution of Abasic Sites (AP sites)

PNKP has several biochemical functions, for example, ATP binding, ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity, damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNKP itself. We selected most functions PNKP had, and list some proteins which have the same functions with PNKP. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCKMT1A;DDR1;DYNC1H1;ACTBL2;DHX30;DHX29;MELK;NEK10;CAMK1GB
ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activityPNKP;CLP1
damaged DNA bindingRBBP8;HMGB2;POLB;BRCA1;PNKP;RAD23B;XPA;MGMT;TP73
double-stranded DNA bindingNEIL3;TRP63;FEV;USF1;MEN1;SMAD2;LSM14A;RAD51AP1;CGGBP1
endonuclease activityCL2;ANG4;SMG6;RNASE4;APEX1;EAR2;ANG;RNASEL2;EME1
nucleotide kinase activity
polynucleotide 3-phosphatase activityAPTX;PNKP
protein bindingZBTB4;ASAP2;PLAA;NDE1;CTPS2;PRRG2;FZD6;THBS4;BRD7
purine nucleotide bindingPNKP;FAM114A2;P2RX4A

PNKP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNKP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNKP.

XRCC1; XRCC4; ZBTB14

Chatterjee, A; Saha, S; et al. The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3 '-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis. PLOS GENETICS 11:-(2015).
Gao, R; Liu, YP; et al. Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3. PLOS GENETICS 11:-(2015).
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