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PNPLA8

  • Official Full Name

    patatin-like phospholipase domain containing 8

  • Overview

    This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family;are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is;a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript;variants encoding different isoforms have been found for this gene.
  • Synonyms

    PNPLA8; patatin-like phospholipase domain containing 8; calcium-independent phospholipase A2-gamma; IPLA2(GAMMA); IPLA2 2; IPLA2G; PNPLA-gamma; iPLA2 gamma; iPLA2-gamma; patatin-like phospholipase domain-containing protein 8; membrane-associated calcium-i;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PNPLA8-2904H Recombinant Human PNPLA8 protein, His-tagged E.coli His 100-359 aa
Mouse PNPLA8-13047M Recombinant Mouse PNPLA8 Protein Mammalian Cell His
Mouse PNPLA8-6892M-B Recombinant Mouse PNPLA8 Protein Pre-coupled Magnetic Beads HEK293
Mouse PNPLA8-6892M Recombinant Mouse PNPLA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL7645HF Recombinant Full Length Human Calcium-Independent Phospholipase A2-Gamma(Pnpla8) Protein, His-Tagged E.coli expression system His Full Length (1-782)
Mus musculus (Mouse) RFL2474MF Recombinant Full Length Mouse Calcium-Independent Phospholipase A2-Gamma(Pnpla8) Protein, His-Tagged E.coli expression system His Full Length (1-776)
Oryctolagus cuniculus (Rabbit) RFL21327OF Recombinant Full Length Rabbit Calcium-Independent Phospholipase A2-Gamma(Pnpla8) Protein, His-Tagged E.coli expression system His Full Length (1-786)
Rhesus Macaque PNPLA8-3496R Recombinant Rhesus monkey PNPLA8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PNPLA8-3314R Recombinant Rhesus Macaque PNPLA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PNPLA8-3314R-B Recombinant Rhesus Macaque PNPLA8 Protein Pre-coupled Magnetic Beads HEK293
Chicken PNPLA8-3855C Recombinant Chicken PNPLA8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PNPLA8 Related Articles

PNPLA8 involved in several pathways and played different roles in them. We selected most pathways PNPLA8 participated on our site, such as Acyl chain remodelling of PC, Acyl chain remodelling of PE, Eicosanoid Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acyl chain remodelling of PCPLB1;PLA2G16;PNPLA8;PLA2G4B;PLBD1
Acyl chain remodelling of PEPLA2G16;PLBD1;PLA2G4B;PNPLA8
Eicosanoid SynthesisDPEP1;PNPLA8;ALOX5AP
Glycerophospholipid biosynthesisCPNE3;PLD6;CHAT;PNPLA8;CDIPT;STIL;ABHD4;ABHD3;CEPT1A
MetabolismDDAH2;SLC27A2A;APOA4A;GCHFR;AFMID;ITPA;MTF1;SLC5A2;ACOT10
Metabolism of lipids and lipoproteinsELOVL1A;NEU4;ACOT8;FABP9;ARSE;CRAT;GPAT2;MED31;CYP27B1
Phospholipid metabolismABHD4;TPTE;PNPLA8;CHKB;PTPMT1;ARF3;CPNE3;CEPT1;CPNE1

PNPLA8 has several biochemical functions, for example, calcium-independent phospholipase A2 activity, hydrolase activity, lysophospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA8 itself. We selected most functions PNPLA8 had, and list some proteins which have the same functions with PNPLA8. You can find most of the proteins on our site.

Function Related Protein
calcium-independent phospholipase A2 activityPLA2G7;PNPLA8;PLA2G4C;PLA2G15
hydrolase activitySTAMBPA;HE2;HDAC9B;BMP1A;MPPED1;PLA2G4AA;ASPG;DQX1;DPYSL2B
lysophospholipase activityPLA2G4B;PNPLA6;LGALS13;PLA2G4F;PLA2G4AA;LYPLAL1;LYPLA1;PLA2G15;MGLL

PNPLA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA8.

Huang, CF; Dai, CY; et al. Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY 62:512-518(2015).
Mandorfer, M; Payer, BA; et al. Revisiting liver disease progression in HIV/HCV-coinfected patients: the influence of vitamin D, insulin resistance, immune status, IL28B and PNPLA3. LIVER INTERNATIONAL 35:876-885(2015).
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