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POFUT1

Official Full Name

protein O-fucosyltransferase 1
Overview

This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Synonyms

POFUT1; protein O-fucosyltransferase 1; GDP-fucose protein O-fucosyltransferase 1; FUT12; KIAA0180; O Fuc T; O FUT; FUT 12; GDP fucose protein O fucosyltransferase 1; GDP fucose protein O fucosyltransferase1; O FucT 1; O FucT; O FucT1; O-FucT-1; OFuc T; OFucT; OFucT1; OFUT 1; OFUT; OFUT1; OFUT1_HUMAN; Peptide O fucosyltransferase 1; Peptide O fucosyltransferase1; Peptide-O-fucosyltransferase 1; Pofut 1; Protein O fucosyltransferase 1; Protein O fucosyltransferase1; o-fucosyltransferase protein; O-FUT; O-Fuc-T;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POFUT1-7213H	Recombinant Human POFUT1, His-tagged	E.coli	His	27-388aa	Inquiry
Human	POFUT1-3057HCL	Recombinant Human POFUT1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	POFUT1-5152H	Recombinant Human POFUT1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	POFUT1-206H	Recombinant Human POFUT1 Protein, His-tagged	E.coli	His	His238~Phe388	Inquiry
Mouse	Pofut1-207M	Recombinant Mouse Pofut1 Protein, His-tagged	E.coli	His	His243~Phe393	Inquiry
Mouse	Pofut1-986M	Recombinant Mouse Pofut1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Rat	POFUT1-4558R	Recombinant Rat POFUT1 Protein	Mammalian Cell	His		Inquiry
Rat	POFUT1-4218R	Recombinant Rat POFUT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	POFUT1-4218R-B	Recombinant Rat POFUT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	POFUT1-11738Z	Recombinant Zebrafish POFUT1	Mammalian Cell	His		Inquiry
Chicken	POFUT1-5997C	Recombinant Chicken POFUT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
POFUT1 Related Research Area
POFUT1 Related Signal Pathway

POFUT1 involved in several pathways and played different roles in them. We selected most pathways POFUT1 participated on our site, such as Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with POFUT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Other types of O-glycan biosynthesis	ST6GAL2A;ST3GAL3B;GXYLT1;ST6GAL2;B3GAT1A;B3GALTLB;GXYLT1B;POMGNT1;PLOD3

POFUT1 has several biochemical functions, for example, fucosyltransferase activity, peptide-O-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POFUT1 itself. We selected most functions POFUT1 had, and list some proteins which have the same functions with POFUT1. You can find most of the proteins on our site.

Function	Related Protein
fucosyltransferase activity	GLT8D1;FT1;FUT9;FUT6;FUT2;FT2;GTDC2;UGGT1;B3GNT9-PS
peptide-O-fucosyltransferase activity	POFUT1;POFUT2

POFUT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POFUT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POFUT1.

AKT2; H2AFX

Notch Pathway