POLD2
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Official Full Name
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
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Overview
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is;required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear;antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript;variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the;long arm of chromosome 5. -
Synonyms
POLD2; polymerase (DNA directed), delta 2, regulatory subunit 50kDa; polymerase (DNA directed), delta 2, regulatory subunit (50kD); DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; OTTHUMP00000159252; OTTHUMP00000209249; OTTHUMP00000209250;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- POLD2 Related Articles
POLD2 involved in several pathways and played different roles in them. We selected most pathways POLD2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Purine metabolism | POLR1A;NT5C1B;PDE4B;NME2;ENTPD4;PDE4D;POLR2G;PDE6G;NME3 |
Pyrimidine metabolism | POLR2H;TXNRD3;UPP2;DCTPP1;NT5C;POLR2D;PNP5A;TXNRD2;RRM2B |
Metabolic pathways | FUT9A;PNLIPRP3;DCXR;ACAA2;HK1;NDUFS8B;ATP6V0B;PYCR1A;FH1 |
DNA replication | MCM7;PCNA;RPA4;CDT1;RPA2;GINS2;PRIM1;GINS3;MCM6L |
Base excision repair | APEX1;MUTYH;PNKP;UNGA;POLD1;POLE4;HMGB1;PARP2;MBD4 |
Nucleotide excision repair | BIVM-ERCC5;MNAT1;POLE4;NFRKB;COPS7B;INO80B;GPS1;YY1;COPS7A |
Mismatch repair | RPA1;POLD1;RPA3;MSH3;PMS2;POLD4;RFC5;PCNA;RFC1 |
Homologous recombination | SHFM1;BLM;RAD54L;RPA4;TOP3A;RAD51D;POLD1;RAD51L1;RAD51L3 |
HTLV-I infection | RANBP3;NRP1;MAPK8;TRP53INP1;SLC2A1;LCK;NFKB1;TSPO;POLD2 |
POLD2 has several biochemical functions, for example, DNA binding, DNA-directed DNA polymerase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD2 itself. We selected most functions POLD2 had, and list some proteins which have the same functions with POLD2. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | HOXC6A;CERS4A;ZFP687;ZNF777;ZNF12;RBPJA;TFDP2;VENT;C17orf49 |
DNA-directed DNA polymerase activity | POLD2;PAPD7;POLA1;POLD1;CHRAC1;POLD4;POLE4;POLI;POLE |
protein binding | OFCC1;CITED1;C14orf166;PCBD1;MYLIPA;FECH;ACCS;GRM2;KRTAP10-5 |
POLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD2.
POLD1; POLD3; PCNA; POLD4
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