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POLR1C

Official Full Name

polymerase (RNA) I polypeptide C, 30kDa
Overview

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS).
Synonyms

POLR1C; polymerase (RNA) I polypeptide C, 30kDa; DNA-directed RNA polymerases I and III subunit RPAC1; RPA5; RPA39; RPA40; RPAC1; AC40; RPC40; RNA polymerases I and III subunit AC1; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I a;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLR1C-28614TH	Recombinant Human POLR1C, His-tagged	E.coli	His		Inquiry
Human	POLR1C-1838H	Recombinant Human POLR1C, GST-tagged	E.coli	GST	1-346aa	$319 / 25ug
Human	POLR1C-260H	Recombinant Human POLR1C, His-tagged	E.coli	His	1-349aa	Inquiry
Human	POLR1C-3041HCL	Recombinant Human POLR1C 293 Cell Lysate	HEK293	N/A		Inquiry
Human	POLR1C-2762H	Recombinant Human POLR1C Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	POLR1C-13088M	Recombinant Mouse POLR1C Protein	Mammalian Cell	His		Inquiry
Mouse	Polr1c-4993M	Recombinant Mouse Polr1c Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	POLR1C-6918M	Recombinant Mouse POLR1C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	POLR1C-6918M-B	Recombinant Mouse POLR1C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	POLR1C-10846Z	Recombinant Zebrafish POLR1C	Mammalian Cell	His		Inquiry
Chicken	POLR1C-5010C	Recombinant Chicken POLR1C	Mammalian Cell	His		Inquiry
Chicken	POLR1C-5009C	Recombinant Chicken POLR1C	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLR1C Related Articles

POLR1C involved in several pathways and played different roles in them. We selected most pathways POLR1C participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	GMPR;NUDT5;PDE7A;POLR2J;GC2;NT5C3B;URAH;POLE;PDE6A
Pyrimidine metabolism	POLE2;AK9;PNPT1;NME2B.2;TXNRD1;POLR3GLB;POLR2J2;NT5C2B;POLR2L
Metabolic pathways	TKTL1;ATP6V0E1;CBR1L;GKUP;EARS2;GBGT1L4;PANK2;PIGU;AMY1A
RNA polymerase	POLR2J;POLR1B;POLR2L;POLR3K;POLR2F;POLR2C;POLR2GL;POLR3B;POLR2H
Cytosolic DNA-sensing pathway	NFKBIAB;RIPK3;IFNA14;CASP1;IRF3;POLR2F;IL1B;ADAR;IFNA10
Epstein-Barr virus infection	NFKBIB;HSPA2;RAN;MDM2;PSMC1;CSNK2A2;POLR2J3;EIF2AK3;CD19

POLR1C has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1C itself. We selected most functions POLR1C had, and list some proteins which have the same functions with POLR1C. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	EXO1;PTGES2;ARNTL;ZNF285A;PQBP1;SS18L1;MTERFD1;SET;NUP153
DNA-directed RNA polymerase activity	POLR2M;CD3EAP;POLR2J;MED20;POLR2A;POLR2D;CCDC111;PRIM2;POLR1C
contributes_to RNA polymerase I activity	ZNRD1;POLR2EB;POLR1C;POLR2F;POLR1E;POLR2H;POLR2E;POLR2K;TWISTNB
contributes_to RNA polymerase III activity	POLR3F;POLR2F;POLR2E;POLR3D;POLR2H;POLR1D;POLR3G;POLR3K;POLR3GLB
protein binding	CORO2B;EPHB2;MAT2A;DNMT1;APEX1;APAF1;UGP2;ZC4H2;C14orf135
protein dimerization activity	ATOH7;MAX;ASCL3;MNT;POLR2J2;ID2;MXD4;ASCL5;MYCA

POLR1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1C here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1C.

NME1; POLR1D; POLR2J; TNFAIP1

Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).

Achilleos, A; Bugarinovic, G; et al. Polr1c and Polr1d knock-out mice as new genetic models for Treacher Collins Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1875-1875(2014).