POLR2E

  • Official Full Name

    polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

  • Overview

    This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.

  • Synonyms

    POLR2E;polymerase (RNA) II (DNA directed) polypeptide E, 25kDa;polymerase (RNA) II (DNA directed) polypeptide E (25kD);DNA-directed RNA polymerases I, II, and III subunit RPABC1;DNA directed RNA polymerase II 23 kda polypeptide;hRPB25;hsRPB5;RPABC1;RPB5;XAP4;and III subunit ABC1;and III subunit RPABC1;II;DNA directed RNA polymerase II polypeptide E;DNA directed RNA polymerase II subunit E;DNA directed RNA polymerases I II and III subunit RPABC1;DNA-directed RNA polymerase II 23 kDa polypeptide;DNA-directed RNA polymerase II subunit E;DNA-directed RNA polymerases I;RNA polymerases I;RNA polymerases I, II, and III subunit ABC1;RPAB1_HUMAN;RPB5 homolog

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
POLR2E-1843H Recombinant Human POLR2E, GST-tagged E.coli Human GST 1-210aa
POLR2E-28615TH Recombinant Human POLR2E, His-tagged E.coli Human His Full L.
POLR2E-4569R Recombinant Rat POLR2E Protein Mammalian Cells Rat His
POLR2E-521H Recombinant Human POLR2E E.coli Human Non
POLR2E-7061H Recombinant Human POLR2E, His-tagged E.coli Human His 1-210aa
POLR2E-3034HCL Recombinant Human POLR2E 293 Cell Lysate HEK293 Human Non
POLR2E-2514H Recombinant Human POLR2E Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
POLR2E-4229R Recombinant Rat POLR2E Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
POLR2E-4229R-B Recombinant Rat POLR2E Protein Pre-coupled Magnetic Beads HEK293 Rat
Polr2e-4997M Recombinant Mouse Polr2e Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    POLR2E involved in several pathways and played different roles in them. We selected most pathways POLR2E participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pyrimidine metabolism CTPS1A,POLR3GLB,ENTPD8,POLR2A,POLR2K,DTYMK,UCK2B,NT5C3A,POLR2L,ENTPD3
    Cytosolic DNA-sensing pathway ADAR,IFNB,DDX58,IFNB1,TMEM173,IL33,AIM2,Ifna15,POLR1C,RIPK1
    Huntingtons disease HTT,PLCB4,TGM2,ATP5D,GPX1,DCTN2,PPARGC1A,HDAC2,NDUFB4,EP300
    Purine metabolism PAPSS2A,ENTPD4,NUDT9,ADSS,PKM2,PAPSS2,IMPDH1A,AK7B,AK8,POLR2EB
    Epstein-Barr virus infection HSPA6,CD58,PSMD7,TP53,AKAP8L,HSPA1L,PRKACB,NEDD4,NFKBIE,POLR2C
    Metabolic pathways RFK,SDSL,RDH8B,PLA2G5,AGPS,PAFAH1B3,AHCYL2,PLCH1,NDUFS8,DLDH
    RNA polymerase POLR2B,POLR1C,POLR1B,TWISTNB,POLR2J,POLR2C,POLR1A,POLR2G,POLR2EB,POLR2H

    Protein Function

    POLR2E has several biochemical functions, for example, DNA binding,DNA-directed RNA polymerase activity,contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2E itself. We selected most functions POLR2E had, and list some proteins which have the same functions with POLR2E. You can find most of the proteins on our site.

    Function Related Protein
    DNA-directed RNA polymerase activity PRIM2,MED20,POLR3C,POLR3A,CRCP,POLR3K,POLR2L,POLR1C,POLR2EB,POLR3F
    contributes_to RNA polymerase III activity POLR3GL,POLR3F,POLR2H,POLR3C,POLR3H,POLR3G,POLR2F,POLR3GLA,POLR3E,POLR3D
    contributes_to RNA polymerase II activity POLR2B,POLR2K,POLR2J3,POLR2L,POLR2C,POLR2H,POLR2J,POLR2J2,POLR2EB,POLR2A
    protein binding MPPE1,CEP72,HOXA10,MGST1,DVL3,TSTD2,SPINK7,TMX3,FAM107A,GOSR2
    contributes_to RNA polymerase I activity POLR2L,POLR1A,POLR1D,TWISTNB,POLR2K,POLR2H,POLR1C,POLR1E,ZNRD1,POLR2F
    DNA binding FEZF1,MYCB,MNX2A,DHX58,UBP1,EP400,ZNF507,PRDM12,HMGB3B,RBM5

    Interacting Protein

    POLR2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2E here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2E.

    URI1;MED19;MED26;POLR1A;HSP90AA1;TTI1;SRPK1;CDH1;USP11;POLR1E

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