polr2e
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  • Official Full Name
  • polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
  • Background
  • This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
  • Synonyms
  • POLR2E; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; polymerase (RNA) II (DNA directed) polypeptide E (25kD); DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA directed RNA polymerase II 23 kda polypeptide; hRPB25; hsRPB5; RPABC1; RPB5; XAP4; and III subunit ABC1; and III subunit RPABC1; II; DNA directed RNA polymerase II polypeptide E; DNA directed RNA polymerase II subunit E; DNA directed RNA polymerases I II and III subunit RPABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerases I; RNA polymerases I; RNA polymerases I, II, and III subunit ABC1; RPAB1_HUMAN; RPB5 homolog
Cat.#:POLR2E-1843HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E, GST-tagged
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Cat.#:POLR2E-28615THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E, His-tagged
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Cat.#:POLR2E-521HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E
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Cat.#:POLR2E-7061HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E, His-tagged
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Cat.#:POLR2E-4569RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat POLR2E Protein
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Cat.#:POLR2E-3034HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human POLR2E 293 Cell Lysate
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Involved Pathway

POLR2E involved in several pathways and played different roles in them. We selected most pathways POLR2E participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PDE1B; PFAS; PNP5A; AMPD2; GC3; XDH; POLR1B; PRPS1A; NME2B.1; NT5C3A
Pyrimidine metabolism
NT5C1B; UPP2; ENTPD8; CMPK; CTPS1A; POLR3B; AK9; ENTPD6; NME5; POLR1C
Metabolic pathways
COQ3; INPP4A; C1GALT1A; ST3GAL5; CEL.1; GATC; CYP2C55; ALPPL2; IDH2; GALNT11
RNA polymerase
POLR3E; POLR2H; POLR1C; POLR2C; POLR3GLB; POLR3GL; POLR2EB; POLR3A; POLR2E; POLR2J
Cytosolic DNA-sensing pathway
IFI202B; RELA; IFNA3; POLR1D; POLR3B; CCL4L2; IKBKE; POLR2F; CCL4L1; POLR3D
Huntingtons disease
COX5A; UQCR11; ATP5O; SP1; POLR2A; COX4I2; SOD2; DCTN4; HTT; NRF1
Epstein-Barr virus infection
HLA-C; SHFM1; POLR3D; TRAF1; TBPL2; MAP2K6; CD44; POLR3K; HSPA2; PSMD11

Protein Function

POLR2E has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2E itself. We selected most functions POLR2E had, and list some proteins which have the same functions with POLR2E. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein CHD8; LHX1A; C5orf20; POLR3A; ZFP574; TLR8; GPBP1; NKRF; DMRT2; BEND5
Function DNA-directed RNA polymerase activity
Related Protein POLR2E; POLR3K; POLR2M; POLR2A; MED21; POLR1C; POLR3B; PRIM2; RPAP1; MED20
Function contributes_to RNA polymerase I activity
Related Protein POLR2E; POLR1A; POLR1E; POLR2EB; POLR2K; POLR2F; POLR2L; TWISTNB; ZNRD1; POLR1D
Function contributes_to RNA polymerase II activity
Related Protein POLR2C; POLR2J; POLR2E; POLR2B; POLR2H; POLR2J2; POLR2EB; POLR2K; POLR2F; POLR2L
Function contributes_to RNA polymerase III activity
Related Protein CRCP; POLR1D; POLR3B; POLR2H; POLR3K; POLR1C; POLR2E; POLR3E; POLR2L; POLR2K
Function protein binding
Related Protein AMPH; DPYSL5; WDR12; SCAF8; ITCH; NSMCE4A; Ar; AP1G2; PPIC; PPP2R1A

Interacting Protein

POLR2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2E here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2E.
URI1; MED19; MED26; POLR1A; HSP90AA1; TTI1; SRPK1; CDH1; USP11; POLR1E