PPARGC1B

  • Official Full Name

    peroxisome proliferator-activated receptor gamma, coactivator 1 beta

  • Overview

    The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    PPARGC1B;peroxisome proliferator-activated receptor gamma, coactivator 1 beta;peroxisome proliferative activated receptor, gamma, coactivator 1, beta;peroxisome proliferator-activated receptor gamma coactivator 1-beta;PERC;PGC1B;PPARGC-1-beta;PPAR-

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PPARGC1B-1873H Recombinant Human PPARGC1B, GST-tagged E.coli Human GST 1-350aa
PPARGC1B-13164M Recombinant Mouse PPARGC1B Protein Mammalian Cells Mouse His
PPARGC1B-4595R Recombinant Rat PPARGC1B Protein Mammalian Cells Rat His
PPARGC1B-2984HCL Recombinant Human PPARGC1B 293 Cell Lysate HEK293 Human Non
PPARGC1B-4254R Recombinant Rat PPARGC1B Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PPARGC1B-4254R-B Recombinant Rat PPARGC1B Protein Pre-coupled Magnetic Beads HEK293 Rat
PPARGC1B-4646H Recombinant Human PPARGC1B protein, His&Myc-tagged E.coli Human His&Myc 868-1023a.a.
PPARGC1B-6971M Recombinant Mouse PPARGC1B Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PPARGC1B-6971M-B Recombinant Mouse PPARGC1B Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PPARGC1B involved in several pathways and played different roles in them. We selected most pathways PPARGC1B participated on our site, such as AMPK signaling,Energy Metabolism,Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AMPK signaling EEF2,INS-IGF2,CPT1A,SLC2A4RG,ADRa1A,CDKN1A,CPT1C,ELAVL1,CAMKK2,EIF4EBP1
    Metabolism CYP2W1,AKR1C4,AQP1A.2,ALOX5AP,CYP4F11,C2orf56,OXSR1,SLC16A1,ARSD,MAPK1IP1L
    Mitochondrial Gene Expression PPRC1,TFB2M,ESRRA,POLRMT,TFB1M,MTERFD1
    Fatty acid, triacylglycerol, and ketone body metabolism G0S2,CPT1B,MED23,SIN3B,MED16,ACSF3,SLC25A1A,SLC25A20,ACOT8,ACOT7
    Metabolism of lipids and lipoproteins MED22,APOC2,ACOT9.2,MTP,GLTPD1,DHCR24,ACOT7,FABP9,NFYAL,STARD5
    Mitochondrial biogenesis TFB2M,GABPA,PPRC1,MTERF,TFB1M,POLG2,GABPB1,ESRRA,C10orf2,POLRMT
    Energy Metabolism TFB2M,UCP3,UCP2,MEF2B,MYBBP1A,TFB1M,ESRRA,GABPA
    Insulin resistance AKT3A,PYGL,SOCS3,INS2,RPS6KA1,SLC2A2,PRKAB1A,PTENB,TNF,PPP1CB

    Protein Function

    PPARGC1B has several biochemical functions, for example, AF-2 domain binding,RNA binding,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1B itself. We selected most functions PPARGC1B had, and list some proteins which have the same functions with PPARGC1B. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide binding MAP2K2A,PABPC1L2A,HSPA4A,SYNCRIP,MYO7A,DIRAS1B,GTF2F2B,Abca2,RAC1B,DHX32A
    AF-2 domain binding ESRRG,NR0B1
    transcription factor binding MYOCD,IFT172,GCM1,KDM1A,HDAC3,DIP2BA,KAT2B,AHR,AGTR2,RBPJ
    estrogen receptor binding PHB2,MMS19,PRMT2,CTNNB1,WIPI1,ISL1,FUS,TRIP4,LEF1,MED1
    RNA binding PTBP1A,EIF4E2RS1,IFIT14,RPF1,RBM12B2,NSUN6,FBL,SURF6,PUS10,ZFML
    ligand-dependent nuclear receptor transcription coactivator activity TSG101,MED4,SFR1,SLC30A9,USP22,MED14,PPRC1,NCOA3,MED1,CCDC62
    receptor activator activity IGF2,PRKCE
    RNA polymerase II transcription cofactor activity MED7,MED13,PPRC1,MED30,MED20,TDG,CRSP7,NKX2,MED13A,MED17

    Interacting Protein

    PPARGC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1B.

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