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PPARGC1B

Official Full Name

peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Overview

The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms

PPARGC1B; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; peroxisome proliferative activated receptor, gamma, coactivator 1, beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; PERC; PGC1B; PPARGC-1-beta; PPAR-;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPARGC1B-1873H	Recombinant Human PPARGC1B, GST-tagged	E.coli	GST	1-350aa	$319 / 25ug
Human	PPARGC1B-2984HCL	Recombinant Human PPARGC1B 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PPARGC1B-13164M	Recombinant Mouse PPARGC1B Protein	Mammalian Cell	His		Inquiry
Mouse	PPARGC1B-6971M	Recombinant Mouse PPARGC1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PPARGC1B-6971M-B	Recombinant Mouse PPARGC1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PPARGC1B-4595R	Recombinant Rat PPARGC1B Protein	Mammalian Cell	His		Inquiry
Rat	PPARGC1B-4254R	Recombinant Rat PPARGC1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PPARGC1B-4254R-B	Recombinant Rat PPARGC1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PPARGC1B involved in several pathways and played different roles in them. We selected most pathways PPARGC1B participated on our site, such as AMPK signaling, Energy Metabolism, Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
AMPK signaling	INS-IGF2;CPT1B;SLC2A4RG;PPARGC1B;CAMKK2;EIF4EBP1;CDKN1A;ADRA1B;EEF2
Energy Metabolism	MEF2B;MYBBP1A;TFB1M;TFB2M;ESRRA;PPARGC1B;UCP3;GABPA;UCP2
Fatty acid, triacylglycerol, and ketone body metabolism	MED15;MED25;ACOT11;ACOT13;SLC25A1A;CYP7A1;DECR1;ACOT11B;CDK19
Insulin resistance	PPP1R3D;SLC27A5;PPP1CB;MTOR;SLC2A2;G6PCA.2;SOCS3B;PTENA;NFKBIAA
Metabolism	LMF1;SLC25A27;APOBB.1;GLYATL2;ACOT9.2;APOA4B.2;TPTE;MAPK1IP1L;PAICS
Metabolism of lipids and lipoproteins	MTP;CERS5;ARSJ;MED9;SCP2B;BCHE;PMVK;SLC25A20;APOA4B.1
Mitochondrial Gene Expression	TFB1M;PPRC1;POLRMT;PPARGC1B;TFB2M;MTERFD1;ESRRA
Mitochondrial biogenesis	TFB1M;C10orf2;POLRMT;GABPB1;ESRRA;GABPA;MTERF;PPRC1;PPARGC1B

PPARGC1B has several biochemical functions, for example, AF-2 domain binding, RNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1B itself. We selected most functions PPARGC1B had, and list some proteins which have the same functions with PPARGC1B. You can find most of the proteins on our site.

Function	Related Protein
AF-2 domain binding	PPARGC1B;ESRRG;NR0B1
RNA binding	C14orf166;EIF4E2RS1;PSMA1;RBM17;IFIT1;U2AF1L4;NCL;EIF4EB;DZIP3
RNA polymerase II transcription cofactor activity	PPARGC1B;MED19B;CNOT2;TDG;TP53BP1;MED30;PPRC1;MED8;MED19
estrogen receptor binding	TMEM38A;ARRB1;HSD17B10;NKX3-1;WIPI1;TAF10;DDX17;XBP1;TRIP4
ligand-dependent nuclear receptor transcription coactivator activity	ZMIZ2;PPARGC1B;KDM1A;ZCCHC12;ACTN4;RBM14;USP22;PPRC1;SMARCD3
nucleotide binding	ARL8;RBM24A;MAPKAPK2B;CDK12;CAMK2G1;DHX37;RBM39A;TARDBP;HNRNPC
receptor activator activity	PRKCE;IGF2;PPARGC1B
transcription factor binding	ZEB1;E2F5;E2F1;C1QBP;RELA;HDAC3;CDKN2A;NFATC2;JUND

PPARGC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1B.