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PPCDC

Official Full Name

phosphopantothenoylcysteine decarboxylase
Overview

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes;and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to;4-prime-phosphopantetheine (Daugherty et al., 2002 (PubMed 11923312)).
Synonyms

PPCDC; phosphopantothenoylcysteine decarboxylase; FLJ14585; MDS018; CoaC; MGC102190; 1810057I13Rik; 8430432M10Rik; COAC_HUMAN; PPC-DC; RGD1306267;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPCDC-446H	Recombinant Human PPCDC protein, His-tagged	E.coli	His	Met1-Ser204	Inquiry
Human	PPCDC-28672TH	Recombinant Human PPCDC, His-tagged	E.coli	His	204 amino acids	Inquiry
Human	PPCDC-1876H	Recombinant Human PPCDC, GST-tagged	E.coli	GST	1-204aa	$319 / 25ug
Human	PPCDC-2841H	Recombinant Human PPCDC, His-tagged	E.coli	His		Inquiry
Human	PPCDC-2982HCL	Recombinant Human PPCDC 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PPCDC-13167M	Recombinant Mouse PPCDC Protein	Mammalian Cell	His		Inquiry
Mouse	PPCDC-6972M-B	Recombinant Mouse PPCDC Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PPCDC-6972M	Recombinant Mouse PPCDC Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Ppcdc-5033M	Recombinant Mouse Ppcdc Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Ppcdc-1964M	Recombinant Mouse Ppcdc Protein, His-tagged	E.coli	N-His	Met1-Ser204	Inquiry
Rat	Ppcdc-1965R	Recombinant Rat Ppcdc Protein, His-tagged	E.coli	N-His	Met1-Ser242	Inquiry
Zebrafish	PPCDC-11041Z	Recombinant Zebrafish PPCDC	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PPCDC Related Articles

PPCDC involved in several pathways and played different roles in them. We selected most pathways PPCDC participated on our site, such as Pantothenate and CoA biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPCDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pantothenate and CoA biosynthesis	BCAT2;PANK3;PANK1;BCAT1;PANK1B;ENPP3;PPCS;VNN2;ENPP1
Metabolic pathways	MAN1A2;POLR2EB;GANC;GGT7;TPO;CYP24A1;ADH2-2;B3GNT2B;NME6

PPCDC has several biochemical functions, for example, phosphopantothenoylcysteine decarboxylase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPCDC itself. We selected most functions PPCDC had, and list some proteins which have the same functions with PPCDC. You can find most of the proteins on our site.

Function	Related Protein
phosphopantothenoylcysteine decarboxylase activity
protein binding	CEP290;GABBR2;LPAR1;KCTD17;IGSF21B;FGFR4;IFITM1;DOCK1;NACA

PPCDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPCDC here. Most of them are supplied by our site. Hope this information will be useful for your research of PPCDC.

PPIG; FOXR1; SREK1IP1; WDYHV1; TXN2; ZNF232; DBI; PSMA1

Olzhausen, J; Moritz, T; et al. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS YEAST RESEARCH 13:565-573(2013).

Xiang, Z; et al. DFT study on the reaction of the alpha-amino acid anion catalyzed by the aldehyde: Decarboxylation vs. intramolecular CO2 transfer. COMPUTATIONAL AND THEORETICAL CHEMISTRY 1006:1-8(2013).