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PPFIA1

  • Official Full Name

    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

  • Overview

    The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms

    PPFIA1; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; liprin-alpha-1; LIP.1; LIPRIN; Liprin alpha1; LAR interacting protein 1; LIP 1; LIP1; PPFIA 1; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; PTPRF interacting protein alpha 1; LIP-1; Liprin-alpha1; OTTHUMP00000235552; OTTHUMP00000235553; LAR-interacting protein 1; PTPRF-interacting protein alpha-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1;

  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • GST
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPFIA1-8113H Recombinant Human PPFIA1 protein, His & T7-tagged E.coli His/T7 Met1~Ala250 (Accession # Q13136)
Human PPFIA1-1879H Recombinant Human PPFIA1, GST-tagged E.coli GST N-term-350aa
Human PPFIA1-6599H Recombinant Human PPFIA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPFIA1-2599H Recombinant Human PPFIA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PPFIA1-6640H Recombinant Human PPFIA1 Protein (Met1-Ala250), N-His tagged E.coli N-His Met1-Ala250
Mouse Ppfia1-5035M Recombinant Mouse Ppfia1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPFIA1 Related Articles

PPFIA1 involved in several pathways and played different roles in them. We selected most pathways PPFIA1 participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Glutamate Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPFIA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acetylcholine Neurotransmitter Release CyclePPFIA4;RERG;SNAP25A;PPFIA1;SNAP25B;CHAT;STXBP1A;CCDC167;PPFIA2
Dopamine Neurotransmitter Release CycleSYN3;LIN7C;Apba1;CCDC167;PPFIA1;LIN7B;SYN1;PPFIA2;PPFIA4
Glutamate Neurotransmitter Release CyclePPFIA1;ARL6IP5A;SNAP25A;ARL6IP5;SLC1A2B;SNAP25B;ARL6IP5B;CPLX1;CPLX2L
Neuronal SystemPPFIA4;SLC1A2B;LIN7C;SLC6A12;KCNH1;NCALDA;DDX1;KCNK1A;KCNH1B
Neurotransmitter Release CycleARL6IP5A;SLC17A7A;SYN1;SLC6A1A;PPFIA1;Apba1;LIN7B;SYT1A;SLC6A1B
Norepinephrine Neurotransmitter Release CycleRERG;PPFIA4;RAB3AB;PPFIA2;SNAP25A;PPFIA1;UNC13B;STXBP1A;CPLX2L
Serotonin Neurotransmitter Release CyclePPFIA2;SYN2;PPFIA1;CPLX1;PPFIA4;RERG;SYN1;SYN3
Transmission across Chemical SynapsesSLC1A7A;CACNG2B;NCALDA;GRIP1;SLC1A2B;SYN3;RAB3AB;SYN2;PPFIA4

PPFIA1 has several biochemical functions, for example, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPFIA1 itself. We selected most functions PPFIA1 had, and list some proteins which have the same functions with PPFIA1. You can find most of the proteins on our site.

Function Related Protein
protein bindingAZIN2;RIBC1;RGR;BRE;FTH1;IL17RA;KIAA0101;RABL2A;PXMP4
signal transducer activityFPR-RS6;GMFB;MIER1A;TAS2R109;ADRA2DB;ADORA2AB;OLFCG3;OLFR151;EEF1D

PPFIA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPFIA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPFIA1.

PPP2CA; PPP2R5D; MBIP; PPP2R1A; DTNB; TXLNA; CCNH

Unoki, M; Shen, JC; et al. Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. JOURNAL OF BIOLOGICAL CHEMISTRY 281:34677-34686(2006).
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