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PPIE

  • Official Full Name

    peptidylprolyl isomerase E (cyclophilin E)

  • Overview

    The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified.
  • Synonyms

    PPIE; peptidylprolyl isomerase E (cyclophilin E); peptidyl-prolyl cis-trans isomerase E; cyclophilin 33; cyclophilin E; CyP 33; MGC3736; MGC111222; peptidyl prolyl cis trans isomerase E; peptidylprolyl isomerase E; isoform 1; PPIase E; rotamase E; cycloph;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPIE-180H Recombinant Human PPIE protein, T7-tagged E.coli T7
Human PPIE-118H Recombinant Human Peptidylprolyl isomerase E isoform 1, His-tagged E.coli His
Human PPIE-26336TH Recombinant Human PPIE, His-tagged E.coli His
Human PPIE-1885H Recombinant Human PPIE, GST-tagged E.coli GST 1-301aa
Human PPIE-2971HCL Recombinant Human PPIE 293 Cell Lysate HEK293 N/A
Human PPIE-5539H Recombinant Human PPIE Protein (Tyr41-Val264), N-His tagged E.coli N-His Tyr41-Val264
Human PPIE-3418H Recombinant Human PPIE protein, His-tagged E.coli His 1-301 aa
Human PPIE-1685H Recombinant Human PPIE Protein (Met1-Val301), N-His tagged E.coli N-His Met1-Val301
Mouse PPIE-13183M Recombinant Mouse PPIE Protein Mammalian Cell His
Mouse Ppie-7041M Recombinant Mouse Ppie protein, His & T7-tagged E.coli His/T7 Gly12~Gly286 (Accession # Q9QZH3)
Mouse Ppie-5042M Recombinant Mouse Ppie Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PPIE-6982M Recombinant Mouse PPIE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PPIE-6982M-B Recombinant Mouse PPIE Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PPIE-2438Z Recombinant Zebrafish PPIE Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPIE Related Articles

PPIE involved in several pathways and played different roles in them. We selected most pathways PPIE participated on our site, such as DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA RepairKIAA1530;COPS3;ERCC8;ZNF830;INO80;COPS5;EYA4;MCRS1;USP43A
Dual incision in TC-NERZFP830;KIAA1530;ZNF830;PPIE;ERCC8;DDB1;TCEA1
Formation of TC-NER Pre-Incision ComplexTCEA1;ERCC8;COPS6;COPS4;COPS3;GPS1;PPIE;ZNF830;ZFP830
Gap-filling DNA repair synthesis and ligation in TC-NERZFP830;ERCC8;ZNF830;TCEA1;DDB1;PPIE;KIAA1530
Nucleotide Excision RepairCOPS7A;CUL4B;BIVM-ERCC5;ERCC1;MCRS1;GTF2H2;GTF2H2C;COPS7B;POLE2
SpliceosomeISY1-RAB43;THOC3;SRSF2A;SFRS9;HNRNPK;SRSF1;RBM17;PRPF40B;RP9
Transcription-Coupled Nucleotide Excision Repair (TC-NER)ZFP830;ZNF830;COPS6;KIAA1530;COPS8;PPIE;COPS7B;COPS3;COPS2

PPIE has several biochemical functions, for example, RNA binding, cyclosporin A binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIE itself. We selected most functions PPIE had, and list some proteins which have the same functions with PPIE. You can find most of the proteins on our site.

Function Related Protein
RNA bindingSFSWAP;RPS9;TIAL1;HNRNPM;GTF3A;POP4;NUFIP1;MKI67IP;ARHGEF28
cyclosporin A bindingPPIH;PPID;PPIE;PPIC;PPIG;PPIF
nucleotide bindingNLRP9C;ATP2B3A;SRPK1B;CCC2;DHX57;UMPS;BLM;MAP3K4;PAK2B
peptidyl-prolyl cis-trans isomerase activityPIN4;PPIFB;PPIE;PPIL2;FKBPL;FKBP6;PPIL4;FKBP1B;PIN1
poly(A) RNA bindingFNDC3B;MRPL9;MAP4;EIF3H;DHX34;DDX55;RBM12B2;CSTF2T;SF3B4
protein bindingBAG5;MAP4K1;SELE;DAB1;PTH2R;BDKRB1;ADIPOQ;PTPRJ;FLT4

PPIE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIE here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIE.

XAB2; KMT2A; Snw1; HIST1H3D; trx; Cdc5l; Prpf8

Liao, JC; Chiu, CS; et al. Characterization of a novel Cyclophilin-type peptidylprolyl isomerase protein from sweet potato storage roots. BOTANICAL STUDIES 53:315-324(2012).
Xia, HC; Lv, HG; et al. Cloning and characterization of peptidylprolyl isomerase B in the silkworm, Bombyx mori. AFRICAN JOURNAL OF BIOTECHNOLOGY 8:7116-7124(2009).
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