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PPOX

  • Official Full Name

    protoporphyrinogen oxidase

  • Overview

    This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
  • Synonyms

    PPOX; protoporphyrinogen oxidase; variegate porphyria , VP; PPO; VP; V290M; MGC8485;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPOX-1900H Recombinant Human PPOX, His-tagged E.coli His 31-300aa
Human PPOX-2954HCL Recombinant Human PPOX 293 Cell Lysate HEK293 N/A
Human PPOX-4112H Recombinant Human PPOX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPOX-379H Recombinant Human PPOX Protein, His/GST-tagged E.coli His/GST Ile12~Leu471
Human PPOX-01H Recombinant Human PPOX Protein, DYKDDDDK-tagged Human Cells
Human PPOX-3366H Recombinant Human PPOX protein, His-SUMO-tagged E.coli His-SUMO 1-477aa
Human PPOX-4895H Recombinant Human PPOX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PPOX-13208M Recombinant Mouse PPOX Protein Mammalian Cell His
Mouse Ppox-5054M Recombinant Mouse Ppox Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PPOX-6998M Recombinant Mouse PPOX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PPOX-6998M-B Recombinant Mouse PPOX Protein Pre-coupled Magnetic Beads HEK293
Rat Ppox-380R Recombinant Rat Ppox Protein, His-tagged E.coli His Gly9~Ala300
Zebrafish PPOX-3694Z Recombinant Zebrafish PPOX Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PPOX involved in several pathways and played different roles in them. We selected most pathways PPOX participated on our site, such as Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Porphyrin and chlorophyll metabolismBLVRB;GUSB;UGT1A3;COX10;UGT1A6B;UGT2A2;HMOX1A;PPOX;UROD
Metabolic pathwaysPOLG;NAMPT;CERS5;GLULC;AMACR;ATP6V1G1;ATP5IA;UQCRQ;ATP5B

PPOX has several biochemical functions, for example, flavin adenine dinucleotide binding, oxygen-dependent protoporphyrinogen oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPOX itself. We selected most functions PPOX had, and list some proteins which have the same functions with PPOX. You can find most of the proteins on our site.

Function Related Protein
flavin adenine dinucleotide bindingSDHA;GULO;ACOX2;POR;SQLE;DLDH;ACADVL;SQLEA;PPOX
oxygen-dependent protoporphyrinogen oxidase activity

PPOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPOX here. Most of them are supplied by our site. Hope this information will be useful for your research of PPOX.

HAP1; IMMT; COPS5; Alas2; Fech; Cpox; Slc25a4; Ppox; Slc25a5; Vdac2; Abcb7; Tfrc; Glrx5; Steap3; Sfxn1; Tmem14c; Slc25a11; Abcb10; Sucla2

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