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PPY

  • Official Full Name

    pancreatic polypeptide

  • Overview

    Human Pancreatic Polypeptide (PP or Pancreatic hormone) is synthesized by neuroendocrine cells in the pancreas and is found in enteric nerves. Its release is stimulated during all phases of digestion and increases gastric acid secretion and motility in the stomach and intestine. PP has been shown to suppress appetite. Mice and men with overweight have relatively low levels of PP in contrast to anorexics, which have increased levels of PP. Transgenic mice with an over expression of PP showed reduced food intake, which was reversed by administration of PP antiserum. PP consists of 36 amino acids and has a molecular weight of 4391 Da.
  • Synonyms

    PPY; pancreatic polypeptide; pancreatic prohormone; PP; pancreatic polypeptide Y; PNP; Obinepitide; Pancreatic prohormone; Pancreatic polypeptide Y; PP; Pancreatic Polypeptide; Pancreatic hormone;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPY-214H Recombinant Human PPY Protein, His-tagged HEK293 His
Human PPY-30779TH Recombinant Human PPY Wheat Germ N/A 95 amino acids
Human PPY-6742H Recombinant Human PPY protein, His & GST-tagged E.coli His/GST Ala30~Pro87 (Accession # P01298)
Human PPY-1408HCL Recombinant Human PPY cell lysate N/A
Human PPY-2877H Recombinant Human PPY Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PPY-395HF Recombinant Full Length Human PPY Protein In Vitro Cell Free System 95 amino acids
Human PPY-5971H Recombinant Human PPY Protein (Ala30-Arg88), C-His tagged Mammalian cells C-His Ala30-Arg88
Mouse Ppy-6743M Recombinant Mouse Ppy protein, His & GST-tagged E.coli His/GST Pro31~Ala97 (Accession # P10601)
Mouse PPY-13285M Recombinant Mouse PPY Protein Mammalian Cell His
Mouse PPY-7053M Recombinant Mouse PPY Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PPY-7053M-B Recombinant Mouse PPY Protein Pre-coupled Magnetic Beads HEK293
Mouse Ppy-5089M Recombinant Mouse Ppy Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PPY-4649R Recombinant Rat PPY Protein Mammalian Cell His
Rat PPY-4308R Recombinant Rat PPY Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPY-4308R-B Recombinant Rat PPY Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PPY-3583R Recombinant Rhesus monkey PPY Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPY-3401R Recombinant Rhesus Macaque PPY Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPY-3401R-B Recombinant Rhesus Macaque PPY Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPY Related Articles

PPY involved in several pathways and played different roles in them. We selected most pathways PPY participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)PROK2;OXGR1;GPR55A;PROKR2;CCL35.1;QRFP;ADORA1;OPN4;GPR132
G alpha (i) signalling eventsS1PR5B;LPAR5A;POMCB;LPAR2A;RGS7;CCL27;RLN3;SSTR2;S1PR1
GPCR downstream signalingOXGR1A.1;NPS;ANXA1;RGS20;PTGDR2;OPN1SW1;RGS4;RXFP2;GPR17
GPCR ligand bindingANXA1;GNB5A;CHRM4;GPRC6A;CRHB;PMCH;CD97;ACKR4;LPAR5A
Peptide ligand-binding receptorsSST;PROKR1A;PROK2;KEL;PPY;NPB;HCRT;SSTR4;RLN2
Signal TransductionMAPK6;CCRL2;EDN3;OTUD7B;FOXH1;PENKA;FAM123B;CRHR2;ANXA1A
Signaling by GPCRS1PR5B;SOUL3;TAS2R13;SOUL4;GPR31B;RCA2.1;CCL35.2;RGS6;OPN4A

PPY has several biochemical functions, for example, G-protein coupled receptor binding, hormone activity, neuropeptide hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPY itself. We selected most functions PPY had, and list some proteins which have the same functions with PPY. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingGNA13B;FCN1;RSPO2;GNA13A;RSPO1;INSL3;PICK1;GNAI2B;SFTPB
hormone activityPOMC;INS;ADCYAP1A;Retnla;IGF2;IFNT2;SST6;PRL7B1;SMTLA
neuropeptide hormone activityPPY;NPY;NPFFL;POMCA;PENK;NPFF;ADCYAP1;C12orf39;CORT
receptor bindingTENC1;PPY;ZAP70;UFD1L;ALCAM;ARPP19;ABCA1;PARK7;FIS1

PPY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPY here. Most of them are supplied by our site. Hope this information will be useful for your research of PPY.

Wang, D; Hu, WH; et al. Multifunctionalized reduced graphene oxide-doped polypyrrole/pyrrolepropylic acid nanocomposite impedimetric immunosensor to ultra-sensitively detect small molecular aflatoxin B-1. BIOSENSORS & BIOELECTRONICS 63:185-189(2015).
Babakhanian, A; Ehzari, H; et al. A novel modified electrode as GC/PPy-AuNPs-rGO/L-Cys/Ag@MUA nanostructure configuration for determination of CCP and CRP antibodies in human blood serum samples. BIOSENSORS & BIOELECTRONICS 63:490-498(2015).
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