PRDX3 Protein


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Official Full Name Peroxiredoxin 3
Background This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
Synonyms PRDX3; peroxiredoxin 3; AOP1; MER5; AOP-1; SP-22; PRO1748; MGC24293; MGC104387; thioredoxin-dependent peroxide reductase, mitochondrial; HBC189; prx-III; peroxiredoxin-3; peroxiredoxin III; OTTHUMP00000020590; protein MER5 homolog; antioxidant protein 1; EC
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • GST
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRDX3-1025H Recombinant Human PRDX3 E.coli N/A
    Human PRDX3-371H Recombinant Human Peroxiredoxin 3 E.coli N/A
    Human PRDX3-822H Recombinant Human Peroxiredoxin 3, T7-tagged E.coli T7
    Mouse Prdx3-1026M Recombinant Mouse Prdx3 E.coli N/A
    Mouse PRDX3-13324M Recombinant Mouse PRDX3 Protein Mammalian Cell His
    Mouse Prdx3-742M Recombinant Mouse Peroxiredoxin 3 E.coli N/A
    Rat PRDX3-4659R Recombinant Rat PRDX3 Protein Mammalian Cell His
    Rhesus Macaque PRDX3-3591R Recombinant Rhesus monkey PRDX3 Protein, His-tagged Mammalian Cell His
    Zebrafish PRDX3-2148Z Recombinant Zebrafish PRDX3 Mammalian Cell His
    Human PRDX3-2881HCL Recombinant Human PRDX3 293 Cell Lysate HEK293 N/A
    Human PRDX3-319H Recombinant Human PRDX3 Protein, His-tagged E.coli His
    Human PRDX3-4361H Recombinant Human PRDX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Prdx3-320M Recombinant Mouse Prdx3 Protein, His/GST-tagged E.coli His/GST
    Mouse Prdx3-611M Recombinant Mouse Prdx3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Prdx3-321R Recombinant Rat Prdx3 Protein, His/GST-tagged E.coli His/GST

    PRDX3 involved in several pathways and played different roles in them. We selected most pathways PRDX3 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress EED; HSPA14; RAD50; RB1CC1; TXNRD2; BMI1A; NUP50; BAG5; KIAA1967; SCMH1
    Detoxification of Reactive Oxygen Species PRDX2; TXNRD2; Txn1; PRDX3; TXN; TXN2
    Selenium Pathway DIO2; PRDX2; SAA2; PRDX4; SERPINA3; SEP15; SAA4; ALOX5AP; MSRB1; SELK
    Validated targets of C-MYC transcriptional activation DDX18; PRDX3; PEG10; LIN28B; NDUFAF2; PDCD10; IREB2; HUWE1; CDCA7; MYCT1

    PRDX3 has several biochemical functions, for example, alkyl hydroperoxide reductase activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX3 itself. We selected most functions PRDX3 had, and list some proteins which have the same functions with PRDX3. You can find most of the proteins on our site.

    Function Related Protein
    alkyl hydroperoxide reductase activity PRDX3; RYROXD1
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process PRDX5; BIRC3; RPS6KA3; SNCA; RPS6KA1; SERPINB9; C1QL4L; AVP; IGF1RA; SERPINB1A
    identical protein binding HAND2; KCNJ10; SHANK1; SIRT1; LUC7L; ACPP; PLDN; ANXA4; CSK; DLC
    kinase binding HPCA; TRADD; PER3; PRKCD; SIT1; PARK7; STRADA; DLG1; PTPN22; MIDN
    protein C-terminus binding MAP3K7; ERCC1; TRP53; SHANK2; GRIP1; MIF4GD; KCNIP3; PEX12; LCK; HIC2
    protein kinase binding DCX; CAMK2N1; TRP53; GPRC5B; TPX2; AXIN1; PTPRR; NGFRAP1; CD8A; THY1
    thioredoxin peroxidase activity PRDX4; PRDX3; PRDX2; PRDX1

    PRDX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX3.


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