|Official Full Name||protein kinase, cAMP-dependent, regulatory, type II, alpha|
|Background||cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]|
|Synonyms||PRKAR2A; protein kinase, cAMP-dependent, regulatory, type II, alpha; PKR2; PRKAR2; cAMP-dependent protein kinase type II-alpha regulatory subunit; protein kinase A, RII-alpha subunit; cAMP-dependent protein kinase regulatory subunit RII alpha;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PRKAR2A involved in several pathways and played different roles in them. We selected most pathways PRKAR2A participated on our site, such as Apoptosis, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Apoptosis||RELA; PPP3R2; STK24; TNFRSFA; NGF; IKBKB; IRF6; JUN; HIST1H1B; IL1B|
|Insulin signaling pathway||GRB2A; PCK2; RPS6; PRKAB1A; RPS6KB2; MAP2K2; INSRA; RPS6KB1B; PDPK1; IRS2|
PRKAR2A has several biochemical functions, for example, cAMP binding, cAMP-dependent protein kinase inhibitor activity, cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAR2A itself. We selected most functions PRKAR2A had, and list some proteins which have the same functions with PRKAR2A. You can find most of the proteins on our site.
|cAMP binding||CNMPD1; PDE11A; PRKAR2A; POPDC2; PDE10A; HCN2; BVES; PRKAR1B; PDE2A; RAPGEF3|
|cAMP-dependent protein kinase inhibitor activity||PKIA; PRKAR1B; PRKAR1A; PKIB; PRKAG2; PRKAR2B; PKIG; PRKAR2A|
|cAMP-dependent protein kinase regulator activity||PRKAR1AA; PRKAG1; PRKAR2AA; PRKAR2AB; PRKAG2; CXCL10; PRKAR1B; PRKAR2B; PRKAR2A; PRKAR1AB|
|protein binding||TBC1D22B; NR4A2; MPP6; NKX3; SF3B3; TUBA3D; POLD4; TES; PELI1; CDK13|
|protein kinase A catalytic subunit binding||EZR; GSK3A; KCNQ1; PRKAR2B; RYR2; PRKAR2A; PJA2; PRKAR1B; GSK3B; SOX9|
|ubiquitin protein ligase binding||PIAS2; ANKRD32; RPA3; UQCRC1; SUMO1; NKD2; UBE2C; GSK3B; UBE2J1; CUL1A|
PRKAR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAR2A.
AKAP1; p03259-2; 3',5'-cyclic amp; PRKACA; AKAP5; AKAP3; 8-aha-camp