PRMT8

  • Official Full Name

    protein arginine methyltransferase 8

  • Overview

    Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

  • Synonyms

    PRMT8;protein arginine methyltransferase 8;HRMT1L3;HRMT1L4;protein arginine N-methyltransferase 8;HMT1 hnRNP methyltransferase-like 3;protein arginine N-methyltransferase 4;heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cells
  • E.coli
  • Wheat Germ
  • HEK293
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    PRMT8 involved in several pathways and played different roles in them. We selected most pathways PRMT8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PRMT8 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity,histone methyltransferase activity (H4-R3 specific),histone-arginine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT8 itself. We selected most functions PRMT8 had, and list some proteins which have the same functions with PRMT8. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RNF168,SLC30A1,CCL20,XRCC2,ORC1L,FEM1C,COL3A1,MAGI1,ACTL6A,KREMEN1
    protein-arginine omega-N asymmetric methyltransferase activity PRMT3,PRMT8B,PRMT7,CARM1,PRMT1,PRMT6,PRMT2
    identical protein binding TYSND1,SNX16,TFRC,PYDC3,GBP5,CLDN9,C,SLC2A1,DPP9,COL18A1
    protein homodimerization activity ALS2,CADM3,MAP3K9,PGCP,HOGA1,PITX2,NOD1,RAP1GAP,CR2,ACCS
    histone methyltransferase activity (H4-R3 specific) PRMT1,PRMT6,PRMT7,PRMT8B
    protein heterodimerization activity DMRTA2,SUPT5H,BIRC5,IL12A,NOTCH1,PRMT5,TTR,MAFGB,ADRA2C,HIST1H4E
    protein-arginine omega-N monomethyltransferase activity PRMT8B,PRMT7,PRMT6
    histone-arginine N-methyltransferase activity CARM1,PRMT2,PRMT5,PRMT6,PRMT7,PRMT3
    S-adenosylmethionine-dependent methyltransferase activity PRMT7,RRP8,SUV39H1,AS3MT,LSM1,LCMT1,TPMT.1,PRMT8B,C6orf211,COQ5

    Interacting Protein

    PRMT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT8.

    SYNCRIP;PRMT1;COIL;VHL;PPARA;DCAF8;CEP162;OFCC1;SERBP1;GPATCH2L;ZNF451

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