PRMT8
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Official Full Name
protein arginine methyltransferase 8
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Background
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008] -
Synonyms
PRMT8; protein arginine methyltransferase 8; HRMT1L3; HRMT1L4; protein arginine N-methyltransferase 8; HMT1 hnRNP methyltransferase-like 3; protein arginine N-methyltransferase 4; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Kit-1863 | PRMT8 Homogeneous Assay Kit | N/A |
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| Kit-1862 | PRMT8 Chemiluminescent Assay Kit | N/A |
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| Human | PRMT8-126H | Recombinant Human PRMT8 Protein, GST-tagged | E. coli | GST |
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| Human | PRMT8-2837HCL | Recombinant Human PRMT8 293 Cell Lysate | HEK293 | N/A |
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| Human | PRMT8-004H | Recombinant Human PRMT8 Protein, GST-tagged | E.coli | GST |
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| Human | PRMT8-5043H | Recombinant Human PRMT8 Protein, GST-tagged | Wheat Germ | GST |
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| Human | PRMT8-180H | Recombinant Human PRMT8 Protein, His-tagged | E.coli | His |
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| Mouse | PRMT8-13422M | Recombinant Mouse PRMT8 Protein | Mammalian Cell | His |
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| Mouse | PRMT8-7128M | Recombinant Mouse PRMT8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | PRMT8-7128M-B | Recombinant Mouse PRMT8 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Prmt8-5136M | Recombinant Mouse Prmt8 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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- Involved Pathway
- Protein Function
- Interacting Protein
PRMT8 involved in several pathways and played different roles in them. We selected most pathways PRMT8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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PRMT8 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity, histone methyltransferase activity (H4-R3 specific), histone-arginine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT8 itself. We selected most functions PRMT8 had, and list some proteins which have the same functions with PRMT8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S-adenosylmethionine-dependent methyltransferase activity | METTL7A;PRMT7;RRP8;MEPCE;ASMT2;TPMT.2;SUV39H1;LSM1;COQ5 |
| histone methyltransferase activity (H4-R3 specific) | PRMT8;PRMT1;PRMT6;PRMT7;PRMT8B |
| histone-arginine N-methyltransferase activity | PRMT3;CARM1;PRMT8;PRMT6;PRMT5;PRMT7;PRMT2 |
| identical protein binding | RAF1;GOT2A;DIAPH1;WRNIP1;NDC80;DRG1;GCC2;TARDBP;CLDN11 |
| protein binding | ATP1A1;GYPB;ZFPM2A;COX6B2;EPN3;RUNDC3A;RIBC2;TBC1D20;C14orf104 |
| protein heterodimerization activity | SDCBP;ADIPOR2;SNX5;DRAP1;SRI;APOA2;CAV2;BNIP3;BNIP3L |
| protein homodimerization activity | MAOB;CSF1R;NTRK1;UGT1A6A;PRLR;GRIK1;TARS;RBM44;NLGN4X |
| protein-arginine omega-N asymmetric methyltransferase activity | PRMT7;CARM1;PRMT8;PRMT6;PRMT1;PRMT2;PRMT8B;PRMT3 |
| protein-arginine omega-N monomethyltransferase activity | PRMT6;PRMT8;PRMT8B;PRMT7 |
PRMT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT8.
SYNCRIP; PRMT1; COIL; VHL; PPARA; DCAF8; CEP162; OFCC1; SERBP1; GPATCH2L; ZNF451
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