PRMT8

  • Official Full Name

    protein arginine methyltransferase 8

  • Overview

    Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

  • Synonyms

    PRMT8;protein arginine methyltransferase 8;HRMT1L3;HRMT1L4;protein arginine N-methyltransferase 8;HMT1 hnRNP methyltransferase-like 3;protein arginine N-methyltransferase 4;heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cells
  • E.coli
  • Wheat Germ
  • HEK293
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    PRMT8 involved in several pathways and played different roles in them. We selected most pathways PRMT8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PRMT8 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity,histone methyltransferase activity (H4-R3 specific),histone-arginine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT8 itself. We selected most functions PRMT8 had, and list some proteins which have the same functions with PRMT8. You can find most of the proteins on our site.

    Function Related Protein
    protein-arginine omega-N asymmetric methyltransferase activity PRMT1,CARM1,PRMT7,PRMT8B,PRMT2,PRMT6,PRMT3
    identical protein binding DAPK2,SHMT2,DNM1L,BCHE,CPT1A,PRDX3,TFRC,SKP2,PUF60,VPS4B
    protein heterodimerization activity SMC4,TAF4B,ADRA1B,GTF2A2,DRD2,TGFB1,Pdgfa&Pdgfb,BCL2L10,DDIT3,TAF6L
    histone methyltransferase activity (H4-R3 specific) PRMT8B,PRMT1,PRMT6,PRMT7
    histone-arginine N-methyltransferase activity PRMT2,PRMT7,CARM1,PRMT3,PRMT5,PRMT6
    protein-arginine omega-N monomethyltransferase activity PRMT7,PRMT8B,PRMT6
    protein homodimerization activity CADM4,GSS,CTBP2,SP1,ATPIF1B,PEX7,BOKA,ACCS,ZBTB16,CR2
    protein binding SOS1,COG2,DZIP1L,GDI2,NUP62L,SIX1,RG9MTD1,MUM1,ATP1A2,GRB2
    S-adenosylmethionine-dependent methyltransferase activity COQ5,PRMT7,TPMT.1,LCMT1,C6orf211,SUV39H1,WBSCR27,RRP8,MEPCE,METTL7A

    Interacting Protein

    PRMT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT8.

    SYNCRIP;PRMT1;COIL;VHL;PPARA;DCAF8;CEP162;OFCC1;SERBP1;GPATCH2L;ZNF451

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