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PSMD2

  • Official Full Name

    proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

  • Overview

    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
  • Synonyms

    PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome non-ATPase regulatory subunit 2; MGC14274; P97; Rpn1; S2; TRAP2; 26S proteasome non ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit non ATPase 2; Protein 55.11; PSMD 2; PSMD2_HUMAN; TNFR associated protein 2; TRAP 2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2; OTTHUMP00000210627; OTTHUMP00000210628; OTTHUMP00000210629; TNFR-associated protein 2; tumor necrosis factor receptor-associated protein 2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PSMD2-2750HCL Recombinant Human PSMD2 293 Cell Lysate HEK293 N/A
Human PSMD2-421H Recombinant Human PSMD2 Protein, His-tagged E.coli His Asp645~Val872
Human PSMD2-6044H Recombinant Human PSMD2 Protein (Asp645-Val872), His tagged E.coli His Asp645-Val872
Mouse Psmd2-5193M Recombinant Mouse Psmd2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PSMD2-4787R Recombinant Rat PSMD2 Protein Mammalian Cell His
Rat PSMD2-4446R-B Recombinant Rat PSMD2 Protein Pre-coupled Magnetic Beads HEK293
Rat PSMD2-4446R Recombinant Rat PSMD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PSMD2-10829Z Recombinant Zebrafish PSMD2 Mammalian Cell His
Chicken PSMD2-2147C Recombinant Chicken PSMD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PSMD2 involved in several pathways and played different roles in them. We selected most pathways PSMD2 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ProteasomePSMD6;IFNG1-2;PSMA4;PSME4;PSMB9B;PSMD12;PSMB9A;PSMA3;PSMC3
Epstein-Barr virus infectionPIK3R1;IL10RA;PIK3CA;MAPK9;POLR2C;PSMD7;HLA-E;YWHAB;POLR3GL

PSMD2 has several biochemical functions, for example, contributes_to endopeptidase activity, enzyme regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD2 itself. We selected most functions PSMD2 had, and list some proteins which have the same functions with PSMD2. You can find most of the proteins on our site.

Function Related Protein
contributes_to endopeptidase activityPSMD2;PSMD1
enzyme regulator activityMTMR9;GCLM;EIF2B1;DCP1B;CPN2;APOC3;PPP1R7;PSMD2;DPM2
protein bindingTIMELESS;BIRC7;BUD31;CXorf40A;NMI;APLF;RAP1A;IK;RARG

PSMD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD2.

PSMC1; UCHL5; BAG1

  • Q&As
  • Reviews

Q&As (7)

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How does PSMD2 contribute to cellular homeostasis? 10/05/2020

PSMD2 helps maintain cellular homeostasis by regulating the turnover of proteins, controlling their abundance and activity.

Can PSMD2 be a target for therapeutic interventions? 01/31/2020

Targeting components of the ubiquitin-proteasome system, including PSMD2, is explored for potential therapeutic interventions in certain diseases.

What is the primary function of PSMD2? 03/05/2019

PSMD2 is a subunit of the 26S proteasome, a cellular complex involved in protein degradation.

Are there diseases associated with PSMD2 dysfunction? 03/01/2018

Dysregulation of proteasomal function, including PSMD2, is implicated in various diseases, such as neurodegenerative disorders and cancer.

Is PSMD2 involved in protein quality control? 09/13/2017

Yes, PSMD2, as part of the 26S proteasome, contributes to protein quality control by degrading misfolded or damaged proteins.

In what cellular processes does PSMD2 play a role? 04/19/2017

PSMD2 plays a crucial role in the ubiquitin-proteasome system, participating in targeted protein degradation.

What is the subcellular location of PSMD2? 01/04/2016

PSMD2 is typically found in the nucleus and cytoplasm, reflecting its involvement in cellular protein degradation processes.

Customer Reviews (3)

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Reviews
02/25/2021

    The product's stability over extended periods was a significant advantage for our long-term research projects.

    01/05/2021

      Consistency in its performance over time made it a reliable resource for ongoing experiments.

      06/11/2019

        The absence of adverse effects on cells or organisms underscored the product's safety and suitability for biological research.

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