psmd2
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  • Official Full Name
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
  • Background
  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
  • Synonyms
  • PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome non-ATPase regulatory subunit 2; MGC14274; P97; Rpn1; S2; TRAP2; 26S proteasome non ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit non ATPase 2; Protein 55.11; PSMD 2; PSMD2_HUMAN; TNFR associated protein 2; TRAP 2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2; OTTHUMP00000210627; OTTHUMP00000210628; OTTHUMP00000210629; TNFR-associated protein 2; tumor necrosis factor receptor-associated protein 2
Cat.#:PSMD2-421HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMD2 Protein, His-tagged
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Cat.#:PSMD2-4787RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PSMD2 Protein
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Cat.#:PSMD2-2147CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PSMD2
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Cat.#:PSMD2-10829ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSMD2
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Cat.#:PSMD2-2750HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMD2 293 Cell Lysate
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Involved Pathway

PSMD2 involved in several pathways and played different roles in them. We selected most pathways PSMD2 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteasome
PSMA6; PSMA2; PSMD12; IFNG1-2; PSMB1; SHFM1; PSMD3; PSMC1; PSMD11; PSMC1A
Epstein-Barr virus infection
CCNA2; PSMD2; PSMC5; AKAP8L; TRAF5; CCNA1; DDX58; RIPK1; TNFAIP3; HDAC2

Protein Function

PSMD2 has several biochemical functions, for example, contributes_to endopeptidase activity, enzyme regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD2 itself. We selected most functions PSMD2 had, and list some proteins which have the same functions with PSMD2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to endopeptidase activity
Related Protein PSMD2; PSMD1
Function enzyme regulator activity
Related Protein PSMD3; APOC3; PPP1R7; PSMD1; BRCC3; ATP6V1H; MTMR9; DPM2; SEPT2; DCP1B
Function protein binding
Related Protein MIIP; SF3B3; NAV2; RAB3B; CDKN1C; BTK; TFDP2; ACSS1; NUMBL; EXD1

Interacting Protein

PSMD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD2.
PSMC1; UCHL5; BAG1