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Official Full Name proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
Synonyms PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome non-ATPase regulatory subunit 2; MGC14274; P97; Rpn1; S2; TRAP2; 26S proteasome non ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit non ATPase 2; Protein 55.11; PSMD 2; PSMD2_HUMAN; TNFR associated protein 2; TRAP 2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2; OTTHUMP00000210627; OTTHUMP00000210628; OTTHUMP00000210629; TNFR-associated protein 2; tumor necrosis factor receptor-associated protein 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PSMD2-2750HCL Recombinant Human PSMD2 293 Cell Lysate HEK293 N/A
    Human PSMD2-421H Recombinant Human PSMD2 Protein, His-tagged E.coli His
    Mouse Psmd2-5193M Recombinant Mouse Psmd2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PSMD2-4787R Recombinant Rat PSMD2 Protein Mammalian Cell His
    Chicken PSMD2-2147C Recombinant Chicken PSMD2 Mammalian Cell His
    Zebrafish PSMD2-10829Z Recombinant Zebrafish PSMD2 Mammalian Cell His

    psmd2 involved in several pathways and played different roles in them. We selected most pathways psmd2 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with psmd2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome PSMA4; PSME4; PSME1; PSMD12; PSMB6; PSMD7; PSMB3; PSMC1A; PSMD2; IFNG1-2
    Epstein-Barr virus infection POLR2L; HSPA1A; STAT3; YWHAE; RBPJ; POLR3GL; HSPA2; SHFM1; CCNA2; ENTPD3

    psmd2 has several biochemical functions, for example, contributes_to endopeptidase activity, enzyme regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by psmd2 itself. We selected most functions psmd2 had, and list some proteins which have the same functions with psmd2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to endopeptidase activity PSMD1; PSMD2
    enzyme regulator activity DPM2; PSMD2; MTMR9; EIF2B1; PSMD3; RGN; PPP1R7; APOC3; GCLM; DCP1B
    protein binding F8; AIG1; TEC; LRRC29; TIA1; DCAF7; PPP1R3C; KLHL22; TNNI2; SCRT1

    psmd2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with psmd2 here. Most of them are supplied by our site. Hope this information will be useful for your research of psmd2.

    PSMC1; UCHL5; BAG1

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