PTEN

  • Official Full Name

    phosphatase and tensin homolog

  • Overview

    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
  • Synonyms

    PTEN; phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • C
  • 6×His
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTEN-1094H Active Recombinant Human Phosphatase And Tensin Homolog Sf21 Insect Cell N/A
Human PTEN-1619H Recombinant Human Phosphatase And Tensin Homolog, GST-tagged E.coli GST
Human PTEN-2042H Recombinant Human PTEN, GST-tagged E.coli GST 204-403aa
Human PTEN-663H Recombinant Human PTEN Protein, His-tagged Sf9 Insect Cell His
Human PTEN-523H Recombinant Human PTEN protein, His-tagged Insect Cell His 403 amino acid
Human PTEN-482H Recombinant Human Phosphatase And Tensin Homolog E.coli N/A
Human PTEN-2721HCL Recombinant Human PTEN 293 Cell Lysate HEK293 N/A
Human PTEN-342H Recombinant Human PTEN Protein, His-tagged E.coli His Thr2~Val403
Human PTEN-078H Recombinant Human PTEN Protein, His-tagged Insect cell His
Human PTEN-31H Recombinant Human PTEN Protein, His-tagged Insect Cell His
Human PTEN-6057H Recombinant Human PTEN Protein (Full Length, G124E), N-GST tagged E.coli N-GST Full Length, G124E
Human PTEN-6058H Recombinant Human PTEN Protein (Met35-Val403), N-His tagged E.coli N-His Met35-Val403
Human PTEN-18H Active Recombinant Human PTEN Protein (Thr2-Val403), C-6×His-tagged E.coli C-6×His Thr2-Val403
Human PTEN-114HFL Recombinant Full Length Human PTEN Protein, C-Flag-tagged Mammalian cells Flag
Human PTEN-2403H Recombinant Human PTEN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTEN-1792H Recombinant Human PTEN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTEN-1792H-B Recombinant Human PTEN Protein Pre-coupled Magnetic Beads HEK293
Mouse PTEN-13631M Recombinant Mouse PTEN Protein Mammalian Cell His
Mouse PTEN-7249M Recombinant Mouse PTEN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTEN-7249M-B Recombinant Mouse PTEN Protein Pre-coupled Magnetic Beads HEK293
Mouse Pten-5216M Recombinant Mouse Pten Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pten-1996M Recombinant Mouse Pten Protein, His-tagged E.coli N-His Thr2-Val403
Rhesus Macaque PTEN-3686R Recombinant Rhesus monkey PTEN Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTEN-3504R-B Recombinant Rhesus Macaque PTEN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PTEN-3504R Recombinant Rhesus Macaque PTEN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • PTEN Related Signal Pathway

PTEN involved in several pathways and played different roles in them. We selected most pathways PTEN participated on our site, such as Inositol phosphate metabolism, FoxO signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismPIK3CB;PIK3C2G;IMPA1;PTENA;PI4K2A;PIK3CD;PI4K2B;MTMR7A;NUDT11
FoxO signaling pathwayTGFB1A;FASLG;PRKAG2;Fasl;BCL6;SOS1;PRKAA1;PIK3R3;IL6
Phosphatidylinositol signaling systemSYNJ1;PIK3C2B;MTMR4;PIK3CG;PIP5K1C;PLCG1;MTMR1;PIKFYVE;CALM1
Sphingolipid signaling pathwayMAP3K5;ROCK1;LASS2;TRP53;DEGS2;SPHK1;PPP2R1A;RHOA;BID
p signaling pathwaySIAH1A;CCNG1;SERPINE1;CASP3A;CASP9;ATM;CD82B;CDK1;PPM1DA
mTOR signaling pathwayPIK3R3;RPS6KA3A;MAPK3;PIK3CA;TNF;RPS6KAL;PTENA;RPS6KA3;PDPK1
PIK-Akt signaling pathwayGNG7;ITGA1;FGF18;PPP2R5C;STK11;IFNA12;ANGPT4;FLT4;ITGB3
Focal adhesionACTN3B;ITGB3B;PPP1R12C;HRASA;ITGB7;LAMA2;COL6A6;PIK3R2;ITGB1A
Tight junctionRRAS2;PRKCD;MYH1A;PPP2CA;PRKCG;CLDNE;CLDNF;PRKCZ;SMYHC1
Insulin resistanceRELA;PYGL;PIK3CB;PIK3R1;PYGB;CREB3L3;RPS6KAL;G6PCA.2;IL6
Hepatitis BHBXIP;CREB5;TLR3;PRKCB;MMP9;SRC;IFNA8;EGR2;NFKB1
Pathways in cancerPLCB3;VEGFA;BDKRB2;HSP90AB1;AKT1;FZD2;FOXO1;GNB1;GNB2
MicroRNAs in cancerFSCN1;RHOA;CYP24A1;FZD3;APC;ABCB1A;BMF;SOCS1;CCND1
Endometrial cancerAPC2;PIK3CA;AKT2;GSK3B;AXIN1;SOS1;TCF7;AKT1;PTEN
GliomaPIK3R2;PRKCG;PDGFRA;CAMK2G;SHC3;SHC1;TRP53;MAP2K1;CALML3
Prostate cancerPDGFRB;TGFA;RELA;SOS1;BCL2;PDGFB;FGFR2;BRAF;CREB5
MelanomaMAP2K2;FGF2;MAPK1;MITF;PIK3R5;FGF12;RAF1;FGF13;IGF1R
Small cell lung cancerRXRA;PIK3R5;BIRC7;RELA;IKBKG;TP53;PIK3R3;PTEN;AKT2
Central carbon metabolism in cancerPFKP;PIK3CA;MTOR;PDK1;PIK3CD;TRP53;MAP2K2;HK1;FGFR1

PTEN has several biochemical functions, for example, PDZ domain binding, anaphase-promoting complex binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTEN itself. We selected most functions PTEN had, and list some proteins which have the same functions with PTEN. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingBAIAP2;ARHGAP29;PARK2;GRM7;F11R;SLC22A5;ATP2B2;PDZK1;TGFBR3
anaphase-promoting complex bindingPLK1;CLSPN;PTEN
enzyme bindingH2AFX;NOTCH3;CSF3;YES1;FAM84B;HAND2;CAD;TP53;SNX12
identical protein bindingACTG1;ZNHIT6;HCFC1;BRI3;SHMT2;PYDC3;SH3GLB1;ALAD;SP100
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
lipid bindingBPIFA3;APOL1;FAM125A;YBX2;FFAR3;MELK;Alb;FABP7;AP2M1B
magnesium ion bindingIDH3A;ENDOV;ENO2;RPS6KA3B;ADSSL1;SIK3;NME1;STK38;PPM1NB
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activityPTEN;PTENA;PTENB
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activityPTENA;PTENB;PTEN
phosphatidylinositol-3-phosphatase activityPTEN;MTMR1B;FIG4;MTM1;MTMR3;SACM1L;MTMR2;MTMR8;MTMR1
phosphoprotein phosphatase activityPPP3CCB;PTPN20;PPM1LB;PPP4CB;PTPRK;CTDSPL2A;PPP1CAB;PPM1AA;PTPRDB
platelet-derived growth factor receptor bindingPDGFRB;PDGFB;ITGA5;PTPRJ;PDGFA;LYN;PDGFD;TYMP;VEGFA
protein bindingNR4A1;METTL15;GTF2A1;S100A6;ATMIN;NOSTRIN;ZNF707;UCP2;SCNN1B
protein kinase bindingCHRNA7;USF1;BORA;CDC25A;YWHAZ;GRB2;H2AFY;FOXO3;NR4A3
protein serine/threonine phosphatase activityCDC14A;PPP2R1A;MTMR3;PPM1N;PPM1NB;TIMM50;PPP3CA;UBLCP1;CDKN3
protein tyrosine phosphatase activityMTMR1B;TPTE;CDC25D;MTMR7A;PTPRNA;MDP1;CDC25C;CDC14A;PTPN2A
protein tyrosine/serine/threonine phosphatase activitySSH3;CDKN3;PTENA;PTP4A2A;DUSP3B;CTDSPL2A;EPM2A;TENC1;DUSP13A

PTEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTEN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTEN.

SLC9A3R1; PDGFRB; FRK; SLC9A3R2

Research Area

Related articles

Ritprajak, P; Azuma, M; et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. ORAL ONCOLOGY 51:221-228(2015).
Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).
  • Q&As
  • Reviews

Q&As (7)

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Apart from its lipid phosphatase activity, what additional function has been attributed to PTEN? 10/01/2022

In addition to its lipid phosphatase activity, PTEN has an additional function known as a scaffolding protein that contributes to its tumor-suppressive role.

In which cellular compartment does PTEN primarily exert its lipid phosphatase function? 01/02/2022

PTEN primarily exerts its lipid phosphatase function in the cytoplasm, where it regulates the PI3K/AKT pathway.

What is the significance of the FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis? 03/30/2020

The significance of FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis involves the loss of PTEN's tumor-suppressive functions, leading to uncontrolled cell growth.

How is the expression of nuclear PTEN (核PTEN) regulated, especially in the context of tumorigenesis? 08/22/2019

The expression of nuclear PTEN (核PTEN) is regulated, especially in the context of tumorigenesis, through mechanisms involving post-translational modifications and subcellular localization.

What differences are observed in the expression patterns of nuclear PTEN and cytoplasmic PTEN (浆PTEN) in various cancer processes? 07/25/2019

Differences in expression patterns of nuclear PTEN and cytoplasmic PTEN in various cancer processes include alterations in nuclear PTEN levels contributing to tumorigenesis.

What is the classical function of the PTEN protein encoded by the PTEN gene? 04/03/2019

The classical function of the PTEN protein is to regulate cell growth and prevent tumor formation by suppressing the PI3K/AKT signaling pathway.

What role does nuclear PTEN play in mediating the non-phosphatase-dependent function? 10/28/2018

Nuclear PTEN plays a role in mediating the non-phosphatase-dependent function related to genomic stability and DNA repair.

Customer Reviews (3)

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Reviews
11/05/2022

    Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

    01/18/2021

      The insights gained from the product's application justified its cost, marking a prudent investment in our research endeavors.

      12/20/2020

        Comprehensive documentation streamlined the integration of the product into our experimental workflow.

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