PTEN
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Official Full Name
phosphatase and tensin homolog
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Overview
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008] -
Synonyms
PTEN; phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- N
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- PTEN Related Signal Pathway
PTEN involved in several pathways and played different roles in them. We selected most pathways PTEN participated on our site, such as Inositol phosphate metabolism, FoxO signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | NUDT3A;PTENB;PLCH1;PLCE1;IPMKB;INPP5L;INPP5KA;PIK3CG;MTM1 |
| FoxO signaling pathway | PIK3CD;FBXO25;GRB2B;HRASB;RAG2;SGK3;NLK1;HOMER1B;S1PR1 |
| Phosphatidylinositol signaling system | INPPL1;PIK3C2B;MTMR1B;PIP5K2;PTENA;PIK3R2;PTEN;CALM3A;PIK3C3 |
| Sphingolipid signaling pathway | AKT1;AKT2;LASS2;S1PR2;RELA;BDKRB2;RAC3;RAF1;PRKCE |
| p signaling pathway | SHISA5;BAX;SIAH2L;CCND2A;RRM2;IGF1;CDK1;CCND3;PIDD1 |
| mTOR signaling pathway | PIK3CB;PDPK1;PRKCBB;PRKCG;HIF1AB;MAPK1;PIK3R5;CAB39;ULK2 |
| PIK-Akt signaling pathway | CASP9;YWHAH;ITGB1;PDGFB;IFNAR2;LPAR6;TNR;PKN2;ITGA6 |
| Focal adhesion | VEGFC;MAPK8;ITGB1;PDGFAB;TNK2;ACTN4;ITGA3;FLNA;ILK |
| Tight junction | JAM3;CLDN7A;CLDN10A;ACTN4;SYMPK;CLDNK;CLDN15A;CLDN16;CLDNJ |
| Insulin resistance | ACACB;G6PC3;PPP1CC;GFPT1;RPS6KA2;PPP1R3CB;SLC27A1B;PTPN11A;NFKBIA |
| Hepatitis B | IFNA12;PIK3CD;TICAM2;TGFB2;ELK1;Fasl;FAS;Ifna15;TNF |
| Pathways in cancer | RASGRP3;STAT5A;GNG7;BMP4;Adcy4;STAT5B;PIK3R1;WNT1;PPARG |
| MicroRNAs in cancer | DNMT3A;GLS;APC2;ATM;RECK;PTGS2;ROCK1;NFKB1;MDM4 |
| Endometrial cancer | RAF1;TRP53;ILK;NRAS;PIK3R1;PIK3CG;GRB2;ARAF;ELK1 |
| Glioma | CCND1;PRKCB;AKT2;PIK3CG;PDGFA;ARAF;MAPK3;PIK3CD;PTEN |
| Prostate cancer | CREB3L2;CPN1;HSP90AB1;IKBKG;NFKBIA;NKX3-1;SMARCD1;CREB3L3;ERBB2 |
| Melanoma | FGF2;FGF22;FGF18;PIK3R5;FGF4;FGF11;FGF1;PDGFC;FGF16 |
| Small cell lung cancer | LAMA3;BCL2;ITGB1;AKT1;LAMB2;MAX;RB1;PIK3R1;PIK3CB |
| Central carbon metabolism in cancer | PKM;ERBB2;FGFR2;HIF1A;PIK3CD;SCO2;G6PDX;TP53;NRAS |
PTEN has several biochemical functions, for example, PDZ domain binding, anaphase-promoting complex binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTEN itself. We selected most functions PTEN had, and list some proteins which have the same functions with PTEN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | GRIK2;NLGN1;ATP2B3B;SNTB1;PLEKHA1;LRP2;Fzd4;CADM1;DOCK4 |
| anaphase-promoting complex binding | PTEN;CLSPN;PLK1 |
| enzyme binding | RAD9A;TNKS2;GBP1;EHHADH;BCHE;PARK7;CYB5A;VAPB;GSTM1 |
| identical protein binding | BAG2;FHOD1;NPR2;C1QTNF2;DAPK3;ALAD;STIM1;LZTFL1;HOOK1 |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | |
| lipid binding | CPTP;PITPNM3;ACOT12;FFAR2;PITPNM2;APOEA;SNX10A;CYTH1;FAM123B |
| magnesium ion binding | PGM1;PTENA;STK3;SNRK;STK4;ENO2;MARK2;S100P;ATP8B1 |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | PTENB;PTEN;PTENA |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | PTEN;PTENA;PTENB |
| phosphatidylinositol-3-phosphatase activity | MTM1;MTMR3;MTMR1;MTMR8;MTMR2;PTEN;MTMR1A;SACM1L;FIG4 |
| phosphoprotein phosphatase activity | PPP4CB;CTDNEP1;CTDNEP1A;PPEF2;PPM1BB;CTDSPL2;DLGAP5;PTPRK;PPP1R3B |
| platelet-derived growth factor receptor binding | PDGFRB;LYN;PDGFA;TYMP;PTEN;VEGFA;PDGFC;ITGB3;PDGFD |
| protein binding | IL-8;CTGF;MC5R;TNIP3;OBSCN;CENPO;TSPAN15;DRD1;GTPBP10 |
| protein kinase binding | CDC42;KCNQ3;PPP1R15A;ADRA2A;ADAM10;DAXX;MS4A2;GATA6;CDK5RAP1 |
| protein serine/threonine phosphatase activity | PPM1AA;PPP2R2A;CTDNEP1B;PHLPP2;PPM1B;PPM1LB;UBLCP1;MTMR3;ILKAP |
| protein tyrosine phosphatase activity | PTPN23;CDC25B;MTMR8;DUSP18;MTMR2;PTPRC;PTPREB;CDC25A;DUSP16 |
| protein tyrosine/serine/threonine phosphatase activity | DUSP4;DUSP23B;PTENB;TPTE;DUSP12;TENC1;DUSP11;CDC14AA;PTP4A3 |
PTEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTEN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTEN.
SLC9A3R1; PDGFRB; FRK; SLC9A3R2
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Write a reviewGel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.
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Q&As (7)
Ask a questionIn addition to its lipid phosphatase activity, PTEN has an additional function known as a scaffolding protein that contributes to its tumor-suppressive role.
PTEN primarily exerts its lipid phosphatase function in the cytoplasm, where it regulates the PI3K/AKT pathway.
The significance of FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis involves the loss of PTEN's tumor-suppressive functions, leading to uncontrolled cell growth.
The expression of nuclear PTEN (核PTEN) is regulated, especially in the context of tumorigenesis, through mechanisms involving post-translational modifications and subcellular localization.
Differences in expression patterns of nuclear PTEN and cytoplasmic PTEN in various cancer processes include alterations in nuclear PTEN levels contributing to tumorigenesis.
The classical function of the PTEN protein is to regulate cell growth and prevent tumor formation by suppressing the PI3K/AKT signaling pathway.
Nuclear PTEN plays a role in mediating the non-phosphatase-dependent function related to genomic stability and DNA repair.
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