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Official Full Name phosphatase and tensin homolog
Background This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Synonyms PTEN; phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PTEN-1094H Recombinant Human Phosphatase And Tensin Homolog Sf21 Insect Cell N/A
    Human PTEN-1619H Recombinant Human Phosphatase And Tensin Homolog, GST-tagged E.coli GST
    Human PTEN-2042H Recombinant Human PTEN, GST-tagged E.coli GST
    Human PTEN-2403H Recombinant Human PTEN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PTEN-2721HCL Recombinant Human PTEN 293 Cell Lysate HEK293 N/A
    Human PTEN-31H Recombinant Human PTEN Protein, His-tagged Insect Cell His
    Human PTEN-342H Recombinant Human PTEN Protein, His-tagged E.coli His
    Human PTEN-482H Recombinant Human Phosphatase And Tensin Homolog E.coli N/A
    Human PTEN-523H Recombinant Human PTEN protein, His-tagged Insect Cell His
    Human PTEN-663H Recombinant Human PTEN Protein, His-tagged Sf9 Insect Cell His
    Mouse PTEN-13631M Recombinant Mouse PTEN Protein Mammalian Cell His
    Mouse Pten-5216M Recombinant Mouse Pten Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque PTEN-3686R Recombinant Rhesus monkey PTEN Protein, His-tagged Mammalian Cell His

    pten involved in several pathways and played different roles in them. We selected most pathways pten participated on our site, such as Inositol phosphate metabolism, FoxO signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with pten were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism PIP4K2C; PIK3C2A; INPPL1; CDIPT; ISYNA1; MTMR7A; MINPP1; NUDT4B; INPP4B; PIK3C2G
    FoxO signaling pathway HRASB; NLK; TGFB3; RBL2; TGFBR1B; TGFBR1; FBXO32; S1PR4; IGF1; STK4
    Phosphatidylinositol signaling system PIK3C2G; PLCZ1; PIP4K2C; PRKCBA; PPIP5K1; PRKCA; PIP5K2; ITPK1A; CALM3A; INPP5E
    Sphingolipid signaling pathway CERS4; BAX; DEGS1; PPP2R2D; PRKCZ; PPP2R3A; SPTLC3; GAB2; TRAF2; PLCB3
    p signaling pathway STEAP3; BIDA; CASP9; RPRM; TRP53; CDK1; BAX; GADD45BA; CASP8; CCNE1
    mTOR signaling pathway DEPDC6; RPS6KA2; CAB39L1; RPS6KA1; PIK3R3; EIF4E2RS1; PRR5; ULK3; PIK3R2; IGF1
    PIK-Akt signaling pathway FGFR2; GNG4; TNC; EPO; GYS2; CREB3L1; IFNA4; NGF; EIF4E2; FOXO3
    Focal adhesion FN1A; ACTN3B; THBS2; BAD; PDGFRB; MYL5; PDGFB; VEGFB; SEPP1; COL6A4
    Tight junction PRKCZ; CDC42L; F11R.1; PPP2R2BB; TJP2A; MYH11A; MYH15; LLGL1; OCLNA; MPP5A
    Pathways in cancer CDH1; RUNX1T1; GNA11; Kitl; PLD1; EGLN1; PIK3CG; LAMA1; IKBKG; KITLG
    MicroRNAs in cancer PIK3CA; SOX4; BMPR2; CYP24A1; EFNA3; PTEN; BCL2L2; SHC4; NRAS; Pdgfa&Pdgfb
    Endometrial cancer PIK3CG; RAF1; MAP2K1; LEF1; CTNNA3; TCF7L2; GRB2; PIK3R1; NRAS; ILK
    Prostate cancer INS2; MDM2; HRAS; CCNE2; NKX3-1; IGF1R; HSP90AA1; FOXA1; INSRR; AKT2
    Melanoma FGF13; FGF20; PIK3R2; Fgf15; HGF; BRAF; FGF9; CCND1; PDGFB; FGF4
    Small cell lung cancer CCNE2; CCND1; TRP53; RARB; LAMA3; BIRC2; ITGB1; AKT2; TP53; IKBKG
    Central carbon metabolism in cancer LDHA; TP53; MAPK3; ERBB2; PKM2; HK3; C12orf5; PIK3R1; HRAS; NTRK1

    pten has several biochemical functions, for example, PDZ domain binding, anaphase-promoting complex binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pten itself. We selected most functions pten had, and list some proteins which have the same functions with pten. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding DLG3; ATP2B3B; FZD7; KCNJ4; SLC26A6; LPAR2; SLC9A3R2; PLEKHA1; ATP2B1B; GNG12
    anaphase-promoting complex binding PLK1; CLSPN; PTEN
    enzyme binding PPP3CB; GSTM1; PGR; HDAC1; CFTR; NR5A1; AKIRIN2; HIST1H2AM; DAOA; YES1
    identical protein binding YWHAZ; MIEF1; SNX1; HAND2; ZNF212; TARDBP; DIAPH1; DYNLRB1; PYDC3; HSP90AA1
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity PTEN
    lipid binding COQ9; FABP6; APODA.1; FABP10A; CYTH1; APOL1; PLEKHA2; PITPNB; NME4; BPIFB4
    magnesium ion binding ALPI; ENOSF1; PTENB; PRPS1A; CERK; CDC42BPG; DYRK3; ZNF143B; NIM1; RPS6KA3A
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity PTEN; PTENA; PTENB
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity PTEN; PTENB; PTENA
    phosphatidylinositol-3-phosphatase activity MTMR1A; PTEN; SACM1L; MTMR14; FIG4; MTMR1B; MTM1; MTMR2; MTMR3; MTMR1
    phosphoprotein phosphatase activity PTPRU; DLGAP5; PPM1LB; SSH2; PTPRJA; CDC25D; SSH1; MTM1; CDC14AA; PPP1CAA
    platelet-derived growth factor receptor binding PDGFRA; PDGFAA; Pdgfa&Pdgfb; PDGFC; LYN; FIGF; PDGFB; PDGFRB; TYMP; IL1R1
    protein binding WDFY2; CORO1B; TOP3A; PIAS1; GRIN2D; DUT; BIRC3; ARID3A; ZNF843; SOCS1
    protein kinase binding USF1; TSKS; ACTA2; PPP1R12B; ILK; CDK5RAP1; MAP3K12; RNF138; TRAF3; MAG
    protein serine/threonine phosphatase activity DUSP23; CDC14A; PPP1CC; PPM1L; CTDNEP1A; PPM1BB; DUSP23B; PPP3CA; PPM1H; PPM1E
    protein tyrosine phosphatase activity MTM1; DUSP13A; PTPRDB; PTPRZ1; SSH2; MTMR14; CDC14AB; EYA3; PTPRU; PTPRNA
    protein tyrosine/serine/threonine phosphatase activity DUSP8A; DUSP19A; SSH2B; PTP4A3; DUSP10; CTDSPL2A; PTP4A1; PTEN; DUSP13; EYA3

    pten has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pten here. Most of them are supplied by our site. Hope this information will be useful for your research of pten.


    Ritprajak, P; Azuma, M; et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. ORAL ONCOLOGY 51:221-228(2015).
    Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).

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