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Official Full Name phosphatase and tensin homolog
Background This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Synonyms PTEN; phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PTEN-078H Recombinant Human PTEN Protein, His-tagged Insect cell His
    Human PTEN-1094H Recombinant Human Phosphatase And Tensin Homolog Sf21 Insect Cell N/A
    Human PTEN-1619H Recombinant Human Phosphatase And Tensin Homolog, GST-tagged E.coli GST
    Human PTEN-2042H Recombinant Human PTEN, GST-tagged E.coli GST
    Human PTEN-2403H Recombinant Human PTEN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PTEN-2721HCL Recombinant Human PTEN 293 Cell Lysate HEK293 N/A
    Human PTEN-31H Recombinant Human PTEN Protein, His-tagged Insect Cell His
    Human PTEN-342H Recombinant Human PTEN Protein, His-tagged E.coli His
    Human PTEN-482H Recombinant Human Phosphatase And Tensin Homolog E.coli N/A
    Human PTEN-523H Recombinant Human PTEN protein, His-tagged Insect Cell His
    Human PTEN-663H Recombinant Human PTEN Protein, His-tagged Sf9 Insect Cell His
    Mouse PTEN-13631M Recombinant Mouse PTEN Protein Mammalian Cell His
    Mouse Pten-5216M Recombinant Mouse Pten Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque PTEN-3686R Recombinant Rhesus monkey PTEN Protein, His-tagged Mammalian Cell His

    PTEN involved in several pathways and played different roles in them. We selected most pathways PTEN participated on our site, such as Inositol phosphate metabolism, FoxO signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism PI4K2B; NUDT3; NUDT4A; INPP5KA; PIK3C2A; PIP5K1AB; MTMR6; PLCZ1; IP6K3; PIK3C2G
    FoxO signaling pathway S1PR4; RAF1; TGFBR1A; SMAD2; IGF1; TGFB3; PIK3R3B; TGFB1; INSRA; RAG1
    Phosphatidylinositol signaling system SYNJ1; PIKFYVE; CALM1A; INPP4B; PI4KA; MTM1; MTMR14; INPPL1A; PLCD1B; PIK3R1
    Sphingolipid signaling pathway PPP2R1A; TRAF2; PLD2; RAC1; ABCC1; PDPK1; BID; PPP2R5C; GNAI2; MAPK3
    p signaling pathway CCND2; STEAP3; BID; CASP9; CCNB3; CCNB2; CASP8; PIDD1; APAF1; GADD45BB
    mTOR signaling pathway EIF4E1B; CAB39L1; INS2; RPS6KAL; DDIT4; PIK3CG; PTEN; PIK3R3; PRKCBA; IGF1
    PIK-Akt signaling pathway MTOR; PPP2R1A; IFNA2; TCL1B4; MDM2; PTEN; LAMB2; PCK2; PPP2R5C; RELA
    Focal adhesion COL6A2; PRKCBA; PAK2A; ACTN3A; MLCK2; DOCK1; ITGA9; IGF1; ITGA4; FN1A
    Tight junction MYL5; PTENB; CLDN18; RAB13; MYH1; GNAIA; PPP2R1A; CLDN17; EPB41; MYH11A
    Insulin resistance IL6; PRKAG2; PIK3R3B; PTEN; MTOR; MAPK8A; MAPK10; PPARAB; PPP2R4; PPP1R3CB
    Hepatitis B IFNA1; TP53; NRAS; IL6; PTEN; IFNA2; EGR3; FASLG; EP300; PIK3R3
    Pathways in cancer SUFU; LAMA5; Kitl; PIK3R3; FADD; KRAS; CBLB; LAMB4; WNT16; IL-8
    MicroRNAs in cancer FOXP1; PIM1; PDCD4; MAPK7; IRS1; HOXD10; Pdgfa&Pdgfb; TNR; SPRY2; KRAS
    Endometrial cancer ERBB2; CCND1; PIK3R5; TCF7L2; PTEN; MAPK3; ARAF; ILK; CDH1; TCF7
    Prostate cancer CREB3L3; TP53; HSP90B1; PIK3CG; PIK3R1; RAF1; HSP90AA1; LEF1; BRAF; INS
    Melanoma FGF18; FGF20; MET; FGF1; MAP2K1; BRAF; PIK3R2; TP53; FGF2; Fgf15
    Small cell lung cancer PIK3CG; PTGS2; TRAF2; MAX; ITGA2; ITGA2B; LAMB2; LAMB3; NOS2; LAMB1
    Central carbon metabolism in cancer PTEN; MAP2K2; FGFR1; PIK3CB; PDHA1; MTOR; G6PDX; SLC2A2; KRAS; MAPK3

    PTEN has several biochemical functions, for example, PDZ domain binding, anaphase-promoting complex binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTEN itself. We selected most functions PTEN had, and list some proteins which have the same functions with PTEN. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding ACCN3; PDZK1; KIDINS220B; FZD8; NSF; NLGN1; GNG12; PLEKHA2; PSEN1; SSTR2
    anaphase-promoting complex binding PLK1; PTEN; CLSPN
    enzyme binding TAL1; MAPK8; DYM; ZNF346; HIF1A; NPM2; A2M; APP; UGT1A7; YES1
    identical protein binding FBXW7; GLE1; KCNJ2; MYD88; SERPINA1A; GOT1L1; CLDN16; STIM1; REG3B; DDX58
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity PTEN
    lipid binding APOA1A; FABP5; ACBD5; ACOT11A; NME4; CYTH4; FAM123B; SNX10A; CRABP2A; LPAR2
    magnesium ion binding PGM1; FDXACB1; TSSK4; IMPA1; IMPA2; PGM5; RPS6KA3; HPGDS; PKMA; PIF1
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity PTENA; PTENB; PTEN
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity PTEN; PTENB; PTENA
    phosphatidylinositol-3-phosphatase activity MTMR3; MTM1; SACM1L; MTMR8; FIG4; MTMR1A; MTMR1B; MTMR1; MTMR14; PTEN
    phosphoprotein phosphatase activity CTDNEP1; CTDSPL2A; PTPRU; PHLPP1; PTPN2B; PPM1BB; CTDNEP1B; PPM1AB; PPTC7; PTPN2A
    platelet-derived growth factor receptor binding PDGFRB; ITGB3; ITGA5; PDGFC; PTEN; IL1R1; PDGFA; PDGFAB; PDGFRA; FIGF
    protein binding KCNA1; LIMS3L; HNRNPU; PSRC1; PEX2; CHD2; SLC19A2; CIZ1; POLL; FOXB1
    protein kinase binding PLK1; DNAJC3; PIFO; TP53; CDKN2D; CDK5R1; STXBP1; TEX14; B4GALT1; RACGAP1
    protein serine/threonine phosphatase activity PPM1BA; PPP3CB; DULLARD; PPM1LB; PPP1R15B; PPP1R3D; PPM1AA; PPP4C; CDC14AA; EPM2A
    protein tyrosine phosphatase activity MTMR7A; SSH3; CDC14C; PTPN2B; DUSP21; MTMR3; PTPRK; PTPRJA; PTPRF; PTPN23A
    protein tyrosine/serine/threonine phosphatase activity SACM1LA; DUSP19A; PTP4A3; SACM1LB; DUSP23; DUSP23A; DUSP3B; PTENA; DUSP1; DUSP3

    PTEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTEN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTEN.


    Ritprajak, P; Azuma, M; et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. ORAL ONCOLOGY 51:221-228(2015).
    Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).

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