Recombinant Human PTEN Protein, His-tagged PTEN-31H

Recombinant Human PTEN Protein, His-tagged

PRODUCTS

Home / Products / Recombinant Human PTEN Protein, His-tagged

Recombinant Human PTEN Protein, His-tagged

PTEN Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : PTEN-31H
Product Overview : Recombinant human PTEN protein with a N-terminal His-tag was expressed in Sf21 cells.
Description : This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Source : Insect cells
Species : Human
Tag : His
Molecular Mass : 50.8 kDa
Purity : ≥95% estimated by SDS-PAGE
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM Tris-HCl, pH 8.0, 100 mM sodium chloride, 5 mM DTT, and 20% glycerol
SDS-PAGE Analysis of PTEN :

Lane 1: MW Markers; Lane 2: PTEN (2 μg); Lane 3: PTEN (5 μg); Lane 4: PTEN (10 μg). Representative gel image shown; actual purity may vary between each batch.

Gene Name : PTEN phosphatase and tensin homolog [ Homo sapiens (human) ]
Official Symbol : PTEN
Synonyms : PTEN; phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; PTENepsilon; mitochondrial PTENalpha; mitochondrial phosphatase and tensin protein alpha; mutated in multiple advanced cancers 1; phosphatase and tensin-like protein; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase
Gene ID : 5728
mRNA Refseq : NM_000314
Protein Refseq : NP_000305
MIM : 601728
UniProt ID : P60484

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy