"PTEN" Related Products

Recombinant Human PTEN protein, His-tagged

Cat.No. : PTEN-523H
Product Overview : Recombinant Human PTEN fused with His tag at C-terminal was expressed in Insect cells.
Description : Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP3). PTEN interacts with many other proteins to regulate cell division and migration, as well as promoting apoptosis when necessary. Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma, making PTEN an important tumor suppressor.
Source : Insect cells
Species : Human
Tag : His
Form : 50 mM Tris-HCl, pH 8.0, containing 100 mM sodium chloride, 5 mM DDT, and 20% glycerol
Molecular Mass : 50.8 kDa
Protein length : 403 amino acid
Purity : > 95% estimated by SDS-PAGE
Stability : 6 months
Storage : Storage at -80 centigrade
Gene Name : PTEN phosphatase and tensin homolog [ Homo sapiens ]
Official Symbol : PTEN
Synonyms : PTEN; phosphatase and tensin homolog; BZS, MHAM; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; MMAC1; mutated in multiple advanced cancers 1; PTEN1; TEP1; phosphatase and tensin-like protein; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; BZS; DEC; GLM2; MHAM; 10q23del; MGC11227;
Gene ID : 5728
mRNA Refseq : NM_000314
Protein Refseq : NP_000305
MIM : 601728
UniProt ID : P60484
Chromosome Location : 10q23
Pathway : 3-phosphoinositide degradation, organism-specific biosystem; 3-phosphoinositide degradation, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, organism-specific biosystem;
Function : PDZ domain binding; anaphase-promoting complex binding; enzyme binding; hydrolase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; magnesium ion binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity;

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