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PTGDR2

Official Full Name

prostaglandin D2 receptor 2
Overview

This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3 UTR of this gene have been associated with asthma susceptibility.
Synonyms

PTGDR2; prostaglandin D2 receptor 2; G protein coupled receptor 44 , GPR44; putative G-protein coupled receptor 44; CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; CRTH2; DP2; CD294 antigen; Chemoattractant receptor homologous molecule expressed on Th2 cells; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH 2; DL1R; G Protein Coupled Receptor 44; GPR 44; Gpr44; GPR44_HUMAN; Putative G protein coupled receptor 44; G protein-coupled receptor 44;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Rat
Rattus norvegicus (Rat)

Source

E.coli expression system
HEK293
Mammalian Cell
Protein Conjugation

Tag

His
Fc
Avi
Flag
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTGDR2-932H	Recombinant Human PTGDR2 Full Length Transmembrane protein(Nanodisc)	HEK293	Non		Inquiry
Human	PTGDR2-1135HFL	Recombinant Human PTGDR2 protein, His&Flag-tagged	HEK293	His&Flag	1-395 aa	Inquiry
Human	PTGDR2-2812H	Recombinant Human PTGDR2 Protein, His-tagged, OVA Conjugated	Protein Conjugation	His	Asp329-Ala348	Inquiry
Rat	PTGDR2-4803R	Recombinant Rat PTGDR2 Protein	Mammalian Cell	His		Inquiry
Rat	PTGDR2-4462R	Recombinant Rat PTGDR2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	PTGDR2-4462R-B	Recombinant Rat PTGDR2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL19244HF	Recombinant Full Length Human Prostaglandin D2 Receptor 2(Ptgdr2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-395)	Inquiry
Rattus norvegicus (Rat)	RFL26992RF	Recombinant Full Length Rat Prostaglandin D2 Receptor 2(Ptgdr2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-403)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PTGDR2 involved in several pathways and played different roles in them. We selected most pathways PTGDR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	CHRM1;OPN1LW2;EDNRAB;ADRB1;NPS;GPR31B;ADRa1A;CCL27;RHOL
Eicosanoid ligand-binding receptors	PTGDR2;CYSLTR1;GPR17;OXER1;LTB4R
G alpha (i) signalling events	NMS;POMCB;S1PR5B;NMUR1;RGS4;FPR-RS6;ADRA2C;CCL35.1;CXCR6
GPCR downstream signaling	RGS4;OPN1MW2;AGT;TAC3;ADM;RGS17;CCL35.1;ADRA2A;TRPC3
GPCR ligand binding	UTS2;CXCR6;CCR9;EMR2;TRH;OPN4.1;LPAR2B;APLNR;OPN1LW
GPCRs, Class A Rhodopsin-like	OPN1LW;GPR31;GPR39;OPN1SW;CMKLR1;FPR-RS4;PTGDR2;FFAR3;CCBP2
Prostanoid ligand receptors
Signal Transduction	EDN3;PENKB;LIN7B;LRP12;STARD13;SDR16C5;IFT172;ARHGEF16;ARHGAP25

PTGDR2 has several biochemical functions, for example, G-protein coupled receptor activity, neuropeptide binding, prostaglandin D receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDR2 itself. We selected most functions PTGDR2 had, and list some proteins which have the same functions with PTGDR2. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	RHOL;OLFR8;PTGER2A;LPAR5A;GPR6;PTGDR2;TMTOPS3A;TAAR15;OR4D2
neuropeptide binding	SSTR1;PTGDR2;MC4R;OPRD1B;OPRK1;MRGPRB1;GPR149;OPRM1;OPRD1A
prostaglandin D receptor activity	PTGDR;PTGDR2
prostaglandin F receptor activity	PTGFR;PTGER1C;PTGDR2
prostaglandin J receptor activity	PTGDR2;PTGDR

PTGDR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGDR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGDR2.