ptgr1
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  • Official Full Name
  • prostaglandin reductase 1
  • Background
  • This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • PTGR1; prostaglandin reductase 1; leukotriene B4 12 hydroxydehydrogenase , LTB4DH; ZADH3; zinc binding alcohol dehydrogenase domain containing 3; PRG-1; 15-oxoprostaglandin 13-reductase; leukotriene B4 12-hydroxydehydrogenase; NADP-dependent leukotriene B
Cat.#:PTGR1-4593HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PTGR1 Protein, GST-tagged
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Cat.#:PTGR1-2520HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prostaglandin Reductase 1, His-tagged
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Cat.#:PTGR1-2048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGR1, GST-tagged
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Cat.#:PTGR1-4814RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTGR1 Protein
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Cat.#:PTGR1-3084CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTGR1
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Cat.#:PTGR1-1936ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PTGR1
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Cat.#:PTGR1-2708HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTGR1 293 Cell Lysate
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Involved Pathway

PTGR1 involved in several pathways and played different roles in them. We selected most pathways PTGR1 participated on our site, such as Arachidonic acid metabolism, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
PLA2G4B; ALOX8; PLA2G12B; CYP2V1; CYP4F11; AKR1C21; PLA2G16; GPX8; PLA2G2D; FAAH2A
Metabolism
TMEM195; ACY3.1; RHAG; CA5B; SGMS2; NUDT10; AKR1C21; DPEP2; APOA4A; CYP51A1
Metabolism of lipids and lipoproteins
FABP1B.1; FAAH2A; ALOX5AP; FIG4; CHKA; BCHE; MTP; PPM1LB; ACOT11; GLTPD1
Synthesis of Leukotrienes (LT) and Eoxins (EX)
ALOX5B.2; DPEP2; PTGR1; DPEP1; ALOX5B.3; ALOX5AP
Synthesis of Lipoxins (LX)
ALOX5B.2; PTGR1; ALOX5B.3
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
FAM213B; PTGR1; PTGDSA
sphingosine and sphingosine-1-phosphate metabolism
PTGR1; ACER1

Protein Function

PTGR1 has several biochemical functions, for example, 13-prostaglandin reductase activity, 15-oxoprostaglandin 13-oxidase activity, 2-alkenal reductase [NAD(P)] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGR1 itself. We selected most functions PTGR1 had, and list some proteins which have the same functions with PTGR1. You can find most of the proteins on our site.
Function
Related Protein
Function 13-prostaglandin reductase activity
Related Protein PTGR2; PTGR1
Function 15-oxoprostaglandin 13-oxidase activity
Related Protein PTGR1; PTGR2
Function 2-alkenal reductase [NAD(P)] activity
Related Protein PTGR1
Function zinc ion binding
Related Protein FNTB; MEP1A.2; MSRB3; MMP12; PGLYRP1; ZFYVE20; SPG7; TRIM5; RABIF; CA6

Interacting Protein

PTGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGR1.
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PTGR1 Related Articles

Zhao, RJ; Pan, ZY; et al. Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells. LIFE SCIENCES 92:10-16(2013).
Naidansuren, P; Park, CW; et al. Molecular characterization of bovine placental and ovarian 20 alpha-hydroxysteroid dehydrogenase. REPRODUCTION 142:723-731(2011).