| Description : |
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
109.4 kDa |
| AA Sequence : |
MGPPLPLLLLLLLLLPPRVLPAAPS SVPRGRQLPGRLDGVFGRCQKVPAM DFYRYEVSPVALQRLRVALQKLSGT GFTWQDDYTQYVMDQELADLPKTYL RRPEASSPARPSKHSVGSERRYSRE GGAALANALRRHLPFLEALSQAPAS DVLARTHTAQDRPPAEGDDRFSESI LTYVAHTSALTYPPGPRTQLREDLL PRTLGQLQPDELSPKVDSGVDRHHL MAALSAYAAQRPPAPPGEGSLEPQY LLRAPSRMPRPLLAPAAPQKWPSPL GDSEDPSSTGDGARIHTLLKDLQRQ PAEVRGLNGLELDGMAELMAGLMQG VDHGVARGSPGRAALGESGEQADGP KATLRGDSFPDDGVQDDDDRLYQEV HRLSATLGGLLQDHGSRLLPGALPF ARPLDMERKKSEHPESSLSSEEETA GVENVKSQTYSKDLLGQQPHSEPGA AAFGELQNQMPGPSKEEQSLPAGAQ EALSDGLQLEVQPSEEEARGYIVTD RDPLRPEEGRRLVEDVARLLQVPSS AFADVEVLGPAVTFKVSANVQNVTT EDVEKATVDNKDKLEETSGLKILQT GVGSKSKLKFLPPQAEQEDSTKFIA LTLVSLACILGVLLASGLIYCLRHS SQHRLKEKLSGLGGDPGADATAAYQ ELCRQRMATRPPDRPEGPHTSRISS VSSQFSDGPIPSPSARSSASSWSEE PVQSNMDISTGHMILSYMEDHLKNK NRLEKEWEALCAYQAEPNSSFVAQR EENVPKNRSLAVLTYDHSRVLLKAE NSHSHSDYINASPIMDHDPRNPAYI ATQGPLPATVADFWQMVWESGCVVI VMLTPLAENGVRQCYHYWPDEGSNL YHIYEVNLVSEHIWCEDFLVRSFYL KNLQTNETRTVTQFHFLSWYDRGVP SSSRSLLDFRRKVNKCYRGRSCPII VHCSDGAGRSGTYVLIDMVLNKMAK GAKEIDIAATLEHLRDQRPGMVQTK EQFEFALTAVAEEVNAILKALPQSG PTRTRRLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
