PTTG1
-
Official Full Name
pituitary tumor-transforming 1
-
Overview
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. -
Synonyms
PTTG1; pituitary tumor-transforming 1; TUTR1; securin; EAP1; ESP1 associated protein 1; HPTTG; PTTG; tumor transforming protein 1; AW555095; C87862; Cut2; EAP 1; Esp1-associated protein; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pituitary tumor-transforming 1, isoform CRA_a; Pituitary tumor-transforming 1, isoform CRA_b; Pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTTG 1; PTTG1 protein; PTTG1_HUMAN; Pttg3; TUMOR TRANSFORMING 1; TUMOR-TRANSFORMING 1; Tumor-transforming protein 1; TUTR 1; OTTHUMP00000160845; OTTHUMP00000224265; OTTHUMP00000224267; ESP1-associated protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- Flag
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PTTG1 Related Articles
PTTG1 involved in several pathways and played different roles in them. We selected most pathways PTTG1 participated on our site, such as Cell cycle, Oocyte meiosis, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTTG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | POT1A;PSMC3IP;PHF8;SET;CENPQ;ORC2L;RAD1;CENPE;CDC16 |
| Oocyte meiosis | CDC27;RPS6KA3B;ANAPC2;ADCY1B;CCNB2;MAPK3;YWHAG;CDC23;YWHAQB |
| HTLV-I infection | MYBL2;DVL1;TGFB2;TGFB1;PDGFA;DVL2;HLA-A;HLA-F;MYBL1 |
PTTG1 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTTG1 itself. We selected most functions PTTG1 had, and list some proteins which have the same functions with PTTG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | CNTNAP1;RAD9;CIT;BCAR1;EFS;PLSCR3;ARHGAP6;VASPA;PTTG2 |
| cysteine-type endopeptidase inhibitor activity | CST4;SERPINB3;CST9L;BIRC7;CST2;STFA2;CARD18;CSTA;NLRC4 |
| peptidase inhibitor activity | MUG1;EPPIN;SERPINA3C;Serpina1c;SERPINB10;WFDC15A;SPINK11;A2ML1;SPINK12 |
| protein binding | NAA16;TECR;TUBGCP3;DDX11;BPTF;SPRY2;IL23R;C14orf104;GSDMD |
| transcription factor activity, sequence-specific DNA binding | ZIC5;NPAS2;ATF7;CLOCK;FOXP3;ZNF8;NFE2L3;AHR1A;E4F1 |
PTTG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTTG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTTG1.
ESPL1; Espl1; PLCG2; DECR1; CRK; SYNCRIP; YEATS4; BAG6; PMS1; HSPG2
- Q&As
- Reviews
Ask a Question for All PTTG1 Products
Required fields are marked with *
My Review for All PTTG1 Products
Required fields are marked with *
