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RAD23A

Official Full Name

RAD23 homolog A
Overview

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Synonyms

RAD23A; RAD23 homolog A (S. cerevisiae); RAD23 (S. cerevisiae) homolog A; UV excision repair protein RAD23 homolog A; HHR23A; MGC111083; RAD23; yeast homolog; A; HR23A; RAD23, yeast homolog, A;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian cells
Yeast

Tag

6×His
Flag
GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAD23A-2153H	Recombinant Human RAD23A protein, GST-tagged	E.coli	GST	1-363 aa	$319 / 25ug
Human	RAD23A-2559HCL	Recombinant Human RAD23A 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RAD23A-1499H	Recombinant Human RAD23A Protein (1-363 aa), His-tagged	Yeast	His	1-363 aa	Inquiry
Human	RAD23A-01H	Recombinant Human RAD23A Protein, His-tagged	E.coli	6×His		Inquiry
Human	RAD23A-1924HFL	Recombinant Full Length Human RAD23A Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	RAD23A-1849H	Recombinant Human RAD23A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	RAD23A-1849H-B	Recombinant Human RAD23A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Rad23a-5348M	Recombinant Mouse Rad23a Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RAD23A involved in several pathways and played different roles in them. We selected most pathways RAD23A participated on our site, such as Nucleotide excision repair, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD23A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Nucleotide excision repair	PPIE;CHD1L;RAD23AB;TFPT;YY1A;PCNA;ERCC8;GTF2H5;COPS6
Protein processing in endoplasmic reticulum	STT3A;PKZ;ATF4;BCL2A;VCP;AMFR;PPP1R15A;EDEM1;MAP3K5

RAD23A has several biochemical functions, for example, damaged DNA binding, polyubiquitin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD23A itself. We selected most functions RAD23A had, and list some proteins which have the same functions with RAD23A. You can find most of the proteins on our site.

Function	Related Protein
damaged DNA binding	RPA3;TRP63;DCLRE1A;NEIL3;XRCC1;EP300;XPA;CREBBP;PCNA
polyubiquitin binding	DZIP3;RAD23B;TNIP3;VCP;UBQLN4;BAG6;TNIP2;BRCC3;THRSP
protein binding	SHKBP1;CTNNA2;SORL1;CLDN16;PTPN22;GOPC;CCNF;SOX17;TWIST1
single-stranded DNA binding	HMGB1;ERCC5;PURB;TDP2;C10orf2;RAD51D;IGHMBP2;RBMS1;SSBP3A
ubiquitin-specific protease binding	BAG6;RAD23A;SART3;AMFR;VPS24;MARCH6;VCP;SELS;CHMP3

RAD23A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD23A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD23A.

PSMD4; TRAF2; TRAF5; TRIP6; ANKRD40; ZBTB44