rad51b

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rad51b

Official Full Name RAD51 paralog B
Background The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]
Synonyms RAD51B; RAD51 paralog B; REC2; R51H2; RAD51L1; DNA repair protein RAD51 homolog 2; RAD51 homolog B; RecA-like protein; recombination repair protein;
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RAD51B-121H Recombinant Human RAD51B protein, T7/His-tagged E.coli T7/His
    Human RAD51B-2465H Recombinant human RAD51B, His-tagged E.coli His
    Human RAD51B-2554HCL Recombinant Human RAD51L1 293 Cell Lysate HEK293 N/A
    Human RAD51L1-2157H Recombinant Human RAD51L1 protein, His-tagged E.coli His
    Zebrafish RAD51B-12585Z Recombinant Zebrafish RAD51B Mammalian Cell His

    rad51b involved in several pathways and played different roles in them. We selected most pathways rad51b participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with rad51b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Homologous recombination RAD51; RAD54L; SSBP1; RPA3; TOP3B; TOP3A; RAD51L1; MUS81; POLD1; RAD51B

    rad51b has several biochemical functions, for example, ATP binding, DNA binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rad51b itself. We selected most functions rad51b had, and list some proteins which have the same functions with rad51b. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PRPS2; MYO1G; QARS; ABCA13; DHX16; MTHFS; BAT1; RAD50; CLK2B; BMPR1BA
    DNA binding HOXA4A; JUNBA; CHD9; ZNF444; SETBP1; PHTF2; TSN; PCXA; NKX2-3; CTC1
    DNA-dependent ATPase activity CDK7; XRCC2; TOP2A; MSH3; SMARCA4; TTF2; IGHMBP2; MSH2; SMARCAL1; CHD8
    double-stranded DNA binding PNKP; TP73; RAD51L1; HMGB2; DMC1; CRY1; MTERFD1; GTF2H4; HES2; RBMS1
    contributes_to endodeoxyribonuclease activity RAD51; RAD51B; DMC1; XRCC2; ERCC4; RAD51D; RAD51L3; RAD51L1
    contributes_to four-way junction DNA binding RAD51C; RAD51D; MSH2; RAD51L3; RAD51B; XRCC3; RAD51L1; XRCC2; MSH6
    protein binding CNO; DCAF12L1; PARVG; IGHMBP2; ULK3; DKK1; TERF2; CLN6; DHX32; MITF
    recombinase activity DMC1; RAD51C; RAD51D; XRCC2; RBPJ; RAD51; RAD51B; RAD51L1; XRCC3; RAD51L3
    single-stranded DNA binding ANXA1; HSPD1; TTC6; ERCC5; TEN1; PCBP1; NME2; MCM7; SWSAP1; BRCA2

    rad51b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rad51b here. Most of them are supplied by our site. Hope this information will be useful for your research of rad51b.

    Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
    McAllister, K; Yarwood, A; et al. Identification of BACH2 and RAD51B as Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data. ARTHRITIS AND RHEUMATISM 65:3058-3062(2013).

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