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RAD51C

Official Full Name

RAD51 homolog C
Overview

This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be;involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two;other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein;in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair.;This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast;tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor;progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have;been identified.
Synonyms

RAD51C; RAD51 homolog C (S. cerevisiae); RAD51 (S. cerevisiae) homolog C; DNA repair protein RAD51 homolog 3; RAD51L2; R51H3; RAD51-like protein 2; yeast RAD51 homolog 3; RAD51 homolog C, isoform 1; FANCO; BROVCA3; MGC104277;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAD51C-680H	Recombinant Human RAD51C Protein, His-tagged	E.coli	His		Inquiry
Human	RAD51C-28601TH	Recombinant Human RAD51C	Wheat Germ	N/A	134 amino acids	Inquiry
Human	RAD51C-2555HCL	Recombinant Human RAD51C 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	RAD51C-13872M	Recombinant Mouse RAD51C Protein	Mammalian Cell	His		Inquiry
Mouse	RAD51C-7387M	Recombinant Mouse RAD51C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RAD51C-7387M-B	Recombinant Mouse RAD51C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RAD51C-1607Z	Recombinant Zebrafish RAD51C	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RAD51C involved in several pathways and played different roles in them. We selected most pathways RAD51C participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	RAD54B;RPA4;RAD51L1;RAD51D;RPA1;RPA3;SHFM1;POLD2;MUS81
Fanconi anemia pathway	TELO2;APITD1;FANCE;FANCF;ERCC1;ZBTB32;RMI1;STRA13;BRIP1

RAD51C has several biochemical functions, for example, ATP binding, DNA binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51C itself. We selected most functions RAD51C had, and list some proteins which have the same functions with RAD51C. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	P2RX8;TTLL10;BCS1L;NEK2;FLT3;FGR;KIFC3;HIPK2;UBE2NB
DNA binding	ZNF23;TFCP2;IKZF1;HOXC3A;TBR1B;SUB1B;SALL1;RCAN1;CREB1B
DNA-dependent ATPase activity	CDK7;CHD6;SMARCA4;RAD51B;DHX36;RAD51D;CHD8;SMARCA2;RAD51C
contributes_to crossover junction endodeoxyribonuclease activity	RAD51C;XRCC3;SLX4
double-stranded DNA binding	PYDC3;PNKP;TRP53;RAD51C;GTF2H4;PRKDC;AIM2;CRY1;HMGB1
contributes_to four-way junction DNA binding	RAD51D;XRCC3;RAD51L1;MSH2;MSH6;RAD51L3;RAD51C;RAD51B;XRCC2
protein binding	DNAJC27;TIMP1;MYL2;RUNX3;TMEM242;TCF7L1A;JAG1;DPCD;CD1B
recombinase activity	RAD51B;XRCC2;RAD51C;DMC1;RBPJ;RAD51L3;RAD51D;RAD51;XRCC3
single-stranded DNA binding	XRCC2;OBFC2B;NABP1A;IGHMBP2;ANXA1;SSBP3A;POLR2GL;SSBP2;MCM10

RAD51C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51C here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51C.

XRCC3; RAD51B; RAD51D