RAMP3
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Official Full Name
receptor (G protein-coupled) activity modifying protein 3
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Overview
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. -
Synonyms
RAMP3; receptor (G protein-coupled) activity modifying protein 3; receptor (calcitonin) activity modifying protein 3 , receptor activity modifying protein 3; receptor activity-modifying protein 3; Calcitonin receptor like receptor activity modifying protein 3; CRLR activity modifying protein 3; Receptor activity modifying protein 3; OTTHUMP00000159549; OTTHUMP00000214279; OTTHUMP00000214280; CRLR activity-modifying protein 3; receptor-activity-modifying protein 3; receptor (calcitonin) activity modifying protein 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Mammalian Cell
- C
- hFc
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- RAMP3 Related Articles
RAMP3 involved in several pathways and played different roles in them. We selected most pathways RAMP3 participated on our site, such as Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcitonin-like ligand receptors | ADM2;CALCRL;ADM2A;RAMP1;RAMP3;RAMP2;CALCA;CALCB;ADM |
| Class B/2 (Secretin family receptors) | EMR3;ADCYAP1B;CRH;GNB5B;ADM;RAMP1;CRHB;PTHLHA;GCGB |
| G alpha (s) signalling events | VIP;RAMP3;CGA;INSL3;ADRB3;CRHR1;RLN3;RLN2;ADM2 |
| GPCR downstream signaling | RGS7;DGKG;KALRNB;KISS1;PROKR1A;CGA;CHRM1;DCLRE1B;ARHGEF18 |
| GPCR ligand binding | INSL5;CRHB;SSTR5;RAMP1;NPSR1;CCR1;RCA2.1;SETD6;SSTR1 |
| Myometrial Relaxation and Contraction Pathways | GPR182;RGS7;PKIB;CRH;CRCP;RGS6;CRHR1;RAMP1;RGS11 |
| Signal Transduction | SCUBE2;TAC1;RGS18;FABP11A;USP9X;RSPO4;LPAR5A;DSCAMA;RNF31 |
| Signaling by GPCR | EMR4;OR7D2;OR4D2;EMR1;PNOCB;OR52J3;RGS14;INSL3;RGR |
RAMP3 has several biochemical functions, for example, coreceptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP3 itself. We selected most functions RAMP3 had, and list some proteins which have the same functions with RAMP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coreceptor activity | LY96;RGMB;CCR8;CXCR6;HFE2;RAMP1;CXCR7;TMIGD2;RGMD |
| protein binding | ZNF792;GCC2;MCPH1;KATNAL1;MSR1;WRNIP1;HIPK2;TAF1D;DRG1 |
| protein transporter activity | IPO8;CALCR;AP1S3B;IPO11;AP1S1;CCT6B;VPS26B;KPNA5;FRAG1 |
| receptor activity | GRIA4B;VMN1R48;TNFRSF9;PAQR3A;GFRA1A;CADM1A;CSF3R;CADM4;TNFRSF11A |
RAMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP3.
KRTAP5-9; NOTCH2NL; HSPB3; PDCD6IP
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