RAPGEF6
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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 6
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Overview
Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene. -
Synonyms
RAPGEF6; Rap guanine nucleotide exchange factor (GEF) 6; PDZ domain containing guanine nucleotide exchange factor (GEF) 2 , PDZGEF2; rap guanine nucleotide exchange factor 6; PDZ GEF2; RA GEF 2; PDZ domain-containing guanine nucleotide exchange factor 2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | RAPGEF6-1632H | Recombinant Human RAPGEF6, GST-tagged | E.coli | GST | 1-164aa | |
| Human | RAPGEF6-499H | Recombinant Human RAPGEF6 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | RAPGEF6-5811H | Recombinant Human RAPGEF6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Rapgef6-5379M | Recombinant Mouse Rapgef6 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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- Involved Pathway
- Protein Function
- Interacting Protein
RAPGEF6 involved in several pathways and played different roles in them. We selected most pathways RAPGEF6 participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FGF8;AKT1;ITGB2;PDGFC;PIK3R3;INS;CALML3;ACTB;ANGPT4 |
RAPGEF6 has several biochemical functions, for example, GTP-dependent protein binding, Ras GTPase binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF6 itself. We selected most functions RAPGEF6 had, and list some proteins which have the same functions with RAPGEF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP-dependent protein binding | AP3B1;RASGRP4;AP1G1;RAB5B;RAB32;HPS6;RAPGEF6;RAPGEF5;GCH1 |
| Ras GTPase binding | MLLT4;CIB1;RAP1GAP;RIN1;RASGRP3;MAPKAP1;RAPGEF4;SPHK2;RGL3 |
| guanyl-nucleotide exchange factor activity | RASGRP2;RASGEF1BA;DOCK11;DOCK5;RASGRP3;TBXAS1;VAV3B;FGD6;ANKRD27 |
| phosphatidic acid binding | MAPKAP1;JPH2;NRGN;UQCC3;COMMD1;PLCD1;SESTD1;PACSIN2;MICALL1 |
| protein binding | IGSF8;NABP1;CGGBP1;HSPA14;ZNF622;CARD9;NAT8B;VAV1;NSMCE2 |
RAPGEF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF6.
- Q&As
- Reviews
Q&As (5)
Ask a questionAnimal models, such as mice with RAPGEF6 gene mutations, are being used to study the impact of RAPGEF6 dysfunction on neurological development and behavior.
RAPGEF6 protein is involved in the regulation of neuronal differentiation, axon guidance, and synaptic plasticity, contributing to proper brain development and function.
Targeting RAPGEF6 protein or its downstream signaling pathways may hold therapeutic potential for certain neurological conditions, but specific interventions are still under investigation.
Genetic testing, such as whole exome sequencing, is employed to identify mutations in the RAPGEF6 gene that may be linked to neurological disorders.
RAPGEF6 has been shown to interact with various proteins involved in synaptic transmission and neuronal signaling, suggesting potential implications in neurological disorders.
Customer Reviews (3)
Write a reviewthe RAPGEF6 protein's high quality and its compatibility with my experimental needs, coupled with the manufacturer's excellent technical support, create a valuable alliance that contributes to successful research endeavors.
The RAPGEF6 protein is characterized by its exceptional quality, making it an ideal choice to fulfill my experimental requirements.
The manufacturer's commitment to providing high-quality proteins is evident in their meticulous production process, ensuring the purity and reliability of the RAPGEF6 protein.
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