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RHEB

  • Official Full Name

    Ras homolog enriched in brain

  • Overview

    Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins that was originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other Ras family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies suggest that Rheb plays an important role in regulating the insulin/mTOR signaling pathway.
  • Synonyms

    RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb; Ras homolog enriched in brain 2; RHEB2; MGC111559;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RHEB-393H Recombinant Human Ras Homolog Enriched in Brain, T7-Tagged E.coli His
Human RHEB-2289H Recombinant Human RHEB, His-tagged E.coli His 1-184aa
Human RHEB-1144H Recombinant Human Ras Homolog Enriched In Brain, GST-tagged E.coli GST
Human RHEB-31324TH Recombinant Human RHEB, His-tagged His
Human RHEB-31326TH Recombinant Human RHEB E.coli N/A
Human RHEB-31325TH Recombinant Human RHEB, T7 -tagged T7
Human RHEB-521H Recombinant Human RHEB, His tagged Insect Cell His
Human RHEB-384H Recombinant Human Ras Homolog Enriched In Brain, His-tagged Sf9 Insect Cell His
Human RHEB-001HCL Recombinant Human RHEB cell lysate Insect Cell N/A
Human RHEB-1181H Recombinant Human RHEB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RHEB-5588H Recombinant Human RHEB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RHEB-6179H Recombinant Human RHEB Protein (Met1-Met184), N-GST tagged E.coli N-GST Met1-Met184
Mouse Rheb-5504M Recombinant Mouse Rheb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat RHEB-5032R Recombinant Rat RHEB Protein Mammalian Cell His
Rat RHEB-4691R-B Recombinant Rat RHEB Protein Pre-coupled Magnetic Beads HEK293
Rat RHEB-4691R Recombinant Rat RHEB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RHEB-3884R Recombinant Rhesus monkey RHEB Protein, His-tagged Mammalian Cell His
Rhesus Macaque RHEB-3701R Recombinant Rhesus Macaque RHEB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RHEB-3701R-B Recombinant Rhesus Macaque RHEB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RHEB-4581Z Recombinant Zebrafish RHEB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RHEB Related Articles
  • RHEB Related Research Area
  • RHEB Related Signal Pathway

RHEB involved in several pathways and played different roles in them. We selected most pathways RHEB participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHEB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayAGPAT4;PIK3R3;CYTH1;DGKD;ARF6;SHC3;PIK3R1;IL-8;FCER1A
mTOR signaling pathwayCAB39L;TSC1;HIF1AB;AKT3A;RPS6KA1;VEGFAB;RRAGCA;STK11;PRKCBA
PIK-Akt signaling pathwayFGF20;IFNA21;PDGFA;ITGA1;IL2RA;ANGPT2;GNGT1;AKT1;GNG7
AMPK signaling pathwayPPARG;PIK3CB;MAP3K7;CAB39;PRKAA1;FASN;CREB3L4;EEF2K;PPP2R1A
Insulin signaling pathwayPPP1CC;CALM3B;PPP1R3D;PRKAA1;PIK3CB;RPTOR;CALM3;FASN;RPS6KB1
Thyroid hormone signaling pathwayPRKCG;NCOA1;ATP1B1;SLC2A1;PLCZ1;ATP1B4;MAP2K2;RXRA;ATP1A2
Choline metabolism in cancerPLA2G4F;PIK3CB;SOS1;EIF4EBP1;PDGFA;MTOR;KRAS;DGKE;PPAP2C

RHEB has several biochemical functions, for example, GTP binding, GTPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RHEB itself. We selected most functions RHEB had, and list some proteins which have the same functions with RHEB. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB38;SEPT9B;RAB1;GSPT1L;RALAA;RAB44;ADSSL;RAB18B;RAB34
GTPase activityIIGP1;EIF2S3Y;GNAT3;RRAS2;RAB42B;SAR1B;NKIRAS1;LGALS6;ARHGDIB
metal ion bindingBCL11AB;YOD1;RNF11A;ASXL3;ZFP622;TIMP4;HDHD1A;PLRDGB;NCALDB
protein bindingBRCA2;RAP2B;FOXO4;SGK3;APPL1;LRRC29;PFKM;IL23;BOC
protein kinase bindingACTA2;MAPK6;TRIB3;BCL10;CALM1;Fert2;LAT;ERRFI1;DNAJC3

RHEB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHEB here. Most of them are supplied by our site. Hope this information will be useful for your research of RHEB.

RAF1; EIF1B; MTOR; TRAF2; RPTOR; CREB3; ARIH2; A2M; NCAM1; Traf2; PSEN2; Appl1; Blzf1; ECSIT; pi3p

Jeon, MT; Nam, JH; et al. In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production. MOLECULAR THERAPY 23:445-455(2015).
Wu, D; Chapman, JR; et al. Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908. JOURNAL OF BIOLOGICAL CHEMISTRY 287:12510-12519(2012).
  • Q&As
  • Reviews

Q&As (5)

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How does RHEB interact with the mTOR pathway, and what implications does this have for clinical interventions 05/29/2021

RHEB directly interacts with the mTOR pathway, a key regulator of cell growth. Understanding this interaction provides insights for developing drugs that target this pathway in diseases like cancer.

Are there any experimental drugs targeting RHEB currently in development? 01/15/2020

Some experimental drugs targeting RHEB are in preclinical development, showing promise in modulating cell growth and survival.

In what ways can the clinical application of RHEB be explored in cancer treatment? 04/24/2018

RHEB's involvement in cell growth makes it a potential target for cancer therapy. Understanding its role may lead to the development of targeted therapies.

Are there any ongoing clinical trials involving RHEB protein in cancer research? 02/18/2018

Research is underway to evaluate the therapeutic potential of targeting RHEB in cancer treatment, with several clinical trials exploring its role as a therapeutic target.

How does the dysregulation of RHEB contribute to diseases? 04/23/2017

Dysregulation of RHEB is associated with various diseases, including cancer and neurological disorders, due to its impact on cell growth and survival pathways.

Customer Reviews (3)

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Reviews
03/07/2020

    Researchers using RHEB protein can benefit from its high purity and quality, ensuring reliable results.

    05/24/2018

      the RHEB protein is available in different formats, including recombinant and purified variants.

      11/13/2017

        This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

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