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RFXAP

  • Official Full Name

    regulatory factor X-associated protein

  • Overview

    Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.
  • Synonyms

    RFXAP; regulatory factor X-associated protein; Regulatory factor X associated protein; RFX associated protein; RFX DNA binding complex 36 kDa subunit; RFX DNA-binding complex 36 kDa subunit; RFX-associated protein; RFXAP_HUMAN; OTTHUMP00000018260;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RFXAP-2267H Recombinant Human RFXAP, GST-tagged E.coli GST C-193aa
Human RFXAP-1496HCL Recombinant Human RFXAP cell lysate N/A
Human RFXAP-2445H Recombinant Human RFXAP protein, His-tagged E.coli His 80-272 aa
Mouse RFXAP-14121M Recombinant Mouse RFXAP Protein Mammalian Cell His
Mouse RFXAP-7555M Recombinant Mouse RFXAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RFXAP-7555M-B Recombinant Mouse RFXAP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RFXAP-3865R Recombinant Rhesus monkey RFXAP Protein, His-tagged Mammalian Cell His
Rhesus Macaque RFXAP-3682R Recombinant Rhesus Macaque RFXAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RFXAP-3682R-B Recombinant Rhesus Macaque RFXAP Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RFXAP involved in several pathways and played different roles in them. We selected most pathways RFXAP participated on our site, such as Antigen processing and presentation, Tuberculosis, Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFXAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationHLA-C;HLA-DQA1;HSPA5;KLRC1;HLA-DOA;HSPA8;TNF;TAP2;HLA-DQB1
TuberculosisRHOA;CLEC4E;HLA-DQA1;RAB5B;CAMK2B;HLA-DMB;BAX;PPP3CC;IFNB1
Primary iCD3D;IKBKG;AICDA;CD19;BTK;UNG;Cd79a, Cd79b;ORAI1;CD40
nodeficiencyIL2RG;TNFRSF13B;ICOS;UNG;CD40LG;CD8B1;TAP1;BLNK;IGLL1

RFXAP has several biochemical functions, for example, DNA binding, transcription coactivator activity, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFXAP itself. We selected most functions RFXAP had, and list some proteins which have the same functions with RFXAP. You can find most of the proteins on our site.

Function Related Protein
DNA bindingASXL1;TNP2;ZBTB43;HIST1H2AB;SREBF1;GPBP1;ZNF521;ZBTB7A;CDKN2A
transcription coactivator activityFHL5;VGLL2;TDRD3;SMARCB1;GTF2A1L;PRDM16;ACTL6B;NCOA3;RAN
transcription factor activity, sequence-specific DNA bindingTCF19;RARAA;ZNF649;BLF;RARGA;EFCAB11;TFAP2C;ZBTB48;MKL1

RFXAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFXAP here. Most of them are supplied by our site. Hope this information will be useful for your research of RFXAP.

EPS8; RFX5; Rfx5

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