RIC8A
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Official Full Name
resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
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Overview
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. -
Synonyms
RIC8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); synembryn-A; synembryn; MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; RIC8; RIC8A_HUMAN;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | RIC8A-2340HCL | Recombinant Human RIC8A 293 Cell Lysate | HEK293 | N/A |
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| Human | RIC8A-2892H | Recombinant Human RIC8A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Ric8a-183M | Recombinant Mouse Ric8a Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Zebrafish | RIC8A-1430Z | Recombinant Zebrafish RIC8A | Mammalian Cell | His |
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| Chicken | RIC8A-2842C | Recombinant Chicken RIC8A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
RIC8A involved in several pathways and played different roles in them. We selected most pathways RIC8A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RIC8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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RIC8A has several biochemical functions, for example, G-protein alpha-subunit binding, GTPase activator activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RIC8A itself. We selected most functions RIC8A had, and list some proteins which have the same functions with RIC8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein alpha-subunit binding | AGTR1A;RGS19;LPAR1;F2RL1;RIC8;PPP5C;CRHR1;ADRB2;DRD1A |
| GTPase activator activity | SGSM2;FAM13A;ECT2;ARHGAP20;RGS5B;SRGAP3;AGAP1;STXBP5A;TBC1D25 |
| guanyl-nucleotide exchange factor activity | ARHGEF3L;RASGRF2B;ARHGEF39;DENND4B;RASGEF1BB;SBF1;DENND6A;RALGDS;SH2D3CB |
| protein binding | SNX32;FHL1;MARK2;DUSP12;NUDT2;NOV;FES;FAM200A;PCSK2 |
RIC8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIC8A here. Most of them are supplied by our site. Hope this information will be useful for your research of RIC8A.
UBQLN1; XPO1; TERF1; GNAI1; TUBB2A; ZNF585B; mutL; yvdC; q8xb62_eco57; UBQLN4; MAPK8IP3; pi3p; Cct4
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