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RIT1

Official Full Name

Ras-like without CAAX 1
Overview

This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38;MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to;promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants.
Synonyms

RIT1; Ras-like without CAAX 1; Ric (Drosophila) like, expressed in many tissues , RIT; GTP-binding protein Rit1; GTP binding protein Roc1; MGC125864; MGC125865; RIBB; Ric like; expressed in many tissues; ROC1; GTP-binding protein Roc1; ras-like without CAAX protein 1; Ric-like, expressed in many tissues; ras-like protein expressed in many tissues; RIT;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	RIT1-2330HCL	Recombinant Human RIT1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	RIT1-6153H	Recombinant Human RIT1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	Rit1-5526M	Recombinant Mouse Rit1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Rhesus Macaque	RIT1-3901R	Recombinant Rhesus monkey RIT1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	RIT1-3718R-B	Recombinant Rhesus Macaque RIT1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	RIT1-3718R	Recombinant Rhesus Macaque RIT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	RIT1-7037Z	Recombinant Zebrafish RIT1	Mammalian Cell	His	Inquiry
Chicken	RIT1-2981C	Recombinant Chicken RIT1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

RIT1 involved in several pathways and played different roles in them. We selected most pathways RIT1 participated on our site, such as NGF signalling via TRKA from the plasma membrane, Neurotrophic factor-mediated Trk receptor signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
NGF signalling via TRKA from the plasma membrane	RIT1;DNAL4B;DNAL4A;RIT2;DNAL4;ADCYAP1;KIDINS220B;NTF7
Neurotrophic factor-mediated Trk receptor signaling	FAIM;RGS19;RIT1;RIT2;GIPC1;MCF2L;DYNLT1
Signal Transduction	ABCA4A;NOXO1A;FGFBP3;ADAM12;CCNT2B;GPR132;ARHGAP36;SKI;GHRH
Signalling by NGF	ARHGEF1B;DNAL4B;PCSK6;RIT2;RTN4A;KIDINS220B;PRDM4;PCSK5;AATF
Signalling to ERKs	RIT2;RIT1;KIDINS220B
Signalling to p38 via RIT and RIN	RIT2;RIT1
Trk receptor signaling mediated by the MAPK pathway	RUSC1;RIT1;RIT2

RIT1 has several biochemical functions, for example, GTP binding, calmodulin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIT1 itself. We selected most functions RIT1 had, and list some proteins which have the same functions with RIT1. You can find most of the proteins on our site.

Function	Related Protein
GTP binding	SEPT5;ARL4AA;EHD1A;MXB;RND3A;ARF3B;SEPHS1;ACSM1;GUCY1B3
calmodulin binding	CAMKK1;KCNN1B;MYO6;CAMK2B;UBR4;EEA1;MARCKSL1B;MARCKSL1A;EEF2K
protein binding	CENPI;ZFYVE28;FLVCR1;TUBA1A;MCL1;MEN1;CACNG2;GTF3C4;GPATCH8

RIT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIT1.

RLF; SRPK2; GRB2; RGL1; IFRD1; AP2A1; PTN; MLLT4; RALGDS; RIF1