RNASEH2B
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Official Full Name
ribonuclease H2, subunit B
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Overview
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). -
Synonyms
RNASEH2B; AGS2; DLEU8; ribonuclease H2, subunit B; ribonuclease H2 subunit B; RNase H2 subunit B; ribonuclease HI subunit B; deleted in lymphocytic leukemia 8; Aicardi-Goutieres syndrome 2 protein;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- RNASEH2B Related Articles
RNASEH2B involved in several pathways and played different roles in them. We selected most pathways RNASEH2B participated on our site, such as DNA replication, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNASEH2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA replication | RPA1;RPA2;GINS4;POLA1;RPA4;GMNN;RFC2;RFC4;FEN1 |
RNASEH2B has several biochemical functions, for example, RNA-DNA hybrid ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNASEH2B itself. We selected most functions RNASEH2B had, and list some proteins which have the same functions with RNASEH2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA-DNA hybrid ribonuclease activity | RNASEH2B;APEX1;RNASEH1;RNASEH2A;EXO1;FEN1;RNASEH2C |
RNASEH2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNASEH2B here. Most of them are supplied by our site. Hope this information will be useful for your research of RNASEH2B.
DAB2IP; SAP18; ARPC5; BRINP1; RNASEH2A; STAMBP; CLPTM1; HIVEP1; RRM1; YWHAQ; FOXM1; PSMD5; RABGAP1L; ZMYM1; RNF213; BCOR; C1orf52; THOC2; RNASEH2C
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