RND2
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Official Full Name
Rho family GTPase 2 -
Overview
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. -
Synonyms
RND2;Rho family GTPase 2;ARHN, ras homolog gene family, member N;rho-related GTP-binding protein RhoN;Rho7;RhoN;ARHN;Rho 7;Rho N;Rho related GTP-binding protein RhoN;Rho-related GTP-binding protein Rho7;Rnd 2;RND2_HUMAN;GTP-binding protein Rho7;ras homolog gene family, member N
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- DDK
- Myc
- Non
- MBP
- Avi
- Fc
Involved Pathway
RND2 involved in several pathways and played different roles in them. We selected most pathways RND2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RND2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RND2 has several biochemical functions, for example, GTP binding,GTPase activity,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RND2 itself. We selected most functions RND2 had, and list some proteins which have the same functions with RND2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCNL2,CWC15,ETV1,PPP1R12C,BAD,FKBP1A,LGI4,TBRG4,ITGB3B,HNRNPH1 |
| protein N-terminus binding | EXOC5,KCNIP2,DAXX,SCFD1,ZWINT,ARF6,SLA2,NCOR2,DCTN4,GTF2H3 |
| GTP binding | EHD2,RRAGCA,LANCL2,DNM3,ARL11,RAB5AB,RAB11BB,RAC1A,GIMAP2,CDC42L |
| GTPase activity | RND1,RAB27B,LSG1,NOA1,GNAI2B,RAB35,RAB23,RABL2,DNAJC27,RAB31 |
Interacting Protein
RND2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RND2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RND2.
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References
- Fichter, CD; Gudernatsch, V; et al. ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. JOURNAL OF MOLECULAR MEDICINE-JMM 92:1209-1223(2014).
- Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
