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Official Full Name ring finger protein 139
Background The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as withCOPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
Synonyms RNF139; ring finger protein 139; E3 ubiquitin-protein ligase RNF139; HRCA1; RCA1; TRC8; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; translocation in renal carcinoma on chromosome 8 protein; MGC31961
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF139-301441H Recombinant Human RNF139 protein, GST-tagged E.coli GST
    Human RNF139-2297HCL Recombinant Human RNF139 293 Cell Lysate HEK293 N/A
    Mouse RNF139-14302M Recombinant Mouse RNF139 Protein Mammalian Cell His
    Rhesus Macaque RNF139-3929R Recombinant Rhesus monkey RNF139 Protein, His-tagged Mammalian Cell His
    Chicken RNF139-2643C Recombinant Chicken RNF139 Mammalian Cell His
    Zebrafish RNF139-6624Z Recombinant Zebrafish RNF139 Mammalian Cell His

    RNF139 involved in several pathways and played different roles in them. We selected most pathways RNF139 participated on our site, such as SREBP signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF139 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    SREBP signalling INSIG1; SEC23B; RBP4; RNF139; DBI; INSIG2

    RNF139 has several biochemical functions, for example, ligase activity, protease binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF139 itself. We selected most functions RNF139 had, and list some proteins which have the same functions with RNF139. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity MKRN1; TRAF3; HLTF; TOPORS; HERC2; MYLIPA; RNF19A; UBE2D1B; RNF5; UBR3
    protease binding MBP; TNFRSF10A; TRIP4; SERPINB3; ADAM8A; Serpina1c; TIMP2; SERPINB13; INS2; NDUFS7
    protein binding POU2F1; HMGN4; ADAM8; TTC1; STMN1; TBC1D16; MOB3C; TPI1; KCNA1; AIM2
    receptor activity TLR6; GRIN1B; PLXNA1; CD160; UNC13B; TNFRSF13B; GRIA2A; TNFRSF11B; TLR1; VMN1R44
    ubiquitin protein ligase activity HECTD3; UBE2W; ANAPC11; RBX1; UBE2S; CCNC; UBE2KB; FBXO40; FANCF; RNF14
    ubiquitin-like protein transferase activity UBL4A; ATG16L1; ARIH1; RNF139; RNF14; ATG3
    ubiquitin-protein transferase activity FBXO25; NEDD4L; MYLIP; BRAP; UHRF2; MDM2; UBA7; FLJ11011L; UBE2R2; TRAF5
    zinc ion binding LONRF3; BTR30; CAD; MT1B; PIAS4B; LASP1; PHF7; RNF180; MID1; RABGEF1

    RNF139 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF139 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF139.

    HM13; XBP1; VHL; UBE2H; UBE2U; UBE2Z

    Wang, XW; Wei, W; et al. RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study. GUT AND LIVER 8:487-494(2014).
    Kato, T; Franconi, CP; et al. Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation. CANCER GENETICS 207:133-140(2014).

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