RNF168
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Official Full Name
ring finger protein 168, E3 ubiquitin protein ligase -
Overview
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. -
Synonyms
RNF168;ring finger protein 168, E3 ubiquitin protein ligase;ring finger protein 168;E3 ubiquitin-protein ligase RNF168;FLJ35794;FLJ39749
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- DDK
- Myc
- Non
Involved Pathway
RNF168 involved in several pathways and played different roles in them. We selected most pathways RNF168 participated on our site, such as Cell Cycle,Cell Cycle Checkpoints,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF168 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | PPP4R2,RTEL1,RAD9,TOPBP1,FUZ,THRSP,TP53BP1,WRN,BRCC3,RHNO1 |
| Cell Cycle Checkpoints | CHEK2,HIST3H2BB,THRSP,MCM8,RAD9B,BABAM1,UIMC1,HUS1,MCM10,KAT5 |
| DNA Double Strand Break Response | UIMC1,EYA2,KDM4B,FAM175A,SMARCA5,BAZ1B,HTATIP,BRCC3,BARD1,KDM4A |
| G2/M Checkpoints | FAM175A,TP53BP1,RAD9A,BRCC3,RAD9B,RAD9,BRE,BABAM1,RAD1,UIMC1 |
| Cell cycle | CHEK2,NUMA1,TGFB2,SET,CDK11A,MPEG1.1,CDK4,MAD1L1,LIN52,CETN2 |
| G2/M DNA damage checkpoint | BRE,UIMC1,BARD1,BABAM1,TP53BP1,THRSP,FAM175A,BRCC3 |
| DNA Repair | DTL,MAD2L2,HUS1,CLSPN,COPS8,PAXIP1,ERCC8,RIF1,USP45,ALKBH2 |
| DNA Double-Strand Break Repair | DNA2,CHEK1,EYA3,RAD9,TOPBP1,TDP1,TIMELESS,PPP4R2A,KDM4B,TDP2B |
Protein Function
RNF168 has several biochemical functions, for example, K63-linked polyubiquitin binding,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF168 itself. We selected most functions RNF168 had, and list some proteins which have the same functions with RNF168. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | MARCH11,ARIH2,RNF220,LIPT2,SIAH1A,DTX3L,TRIML2,STUB1,MYLIPA,TRIM69 |
| zinc ion binding | TMEM163,ERAP1,TRIM62,BTR09,SIAH1,MPI,RNF138,G2E3,LMO3,BTR02 |
| ubiquitin binding | OTUB1A,FAM125A,UCHL3,TOP2A,NBR1,PARK2,PER2,FAN1,UBR5,VPS36 |
| chromatin binding | ARID3C,TAF2,MITF,PCNA,TRIM24,MPO,NR5A1B,PBX2,NEUROD1,TOP2B |
| ubiquitin-protein transferase activity | UBE2D1,UBA7,UBE2L6,UBE2E2,UBE3A,RNF11,RNF144AA,ARIH1L,UBE2D4,TSPAN17 |
| histone binding | HIST1H4M,BRD7,SET,ASF1A,SIRT1,SNCA,HIST1H3E,ANP32B,PIH1D1,DTX3L |
| K63-linked polyubiquitin binding | IKBKG,ZRANB3,TNFAIP3,UIMC1,OTUD7B,ZRANB1B,TAB2,ZRANB1,RNF169,SPRTN |
| protein binding | HIST1H2AG,NELL2,ITGA1,MRPS23,CERS2,HNRNPL,FAM3C,CHEK2,NR2F2,ATP1B2 |
| nucleosome binding | ARID1A,SMARCA5,MUM1,ZNHIT1,NOC2L,RNF4,HP1BP3,DNTTIP1,RNF169,L3MBTL1 |
Interacting Protein
RNF168 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF168 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF168.
UBB;GTF2F2;UBE2N;UBE2G2;LAPTM5;RNF11;PSMD11;UBR5;TBP;TRIP12;CCDC174;SRCAP;RNF169;FAM45A;RPRD1B;NUB1;TACC3;H2AFX
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