RNF168

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RNF168

Official Full Name ring finger protein 168, E3 ubiquitin protein ligase
Background This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
Synonyms RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF168-1520HCL Recombinant Human RNF168 cell lysate N/A
    Human RNF168-2245H Recombinant Human RNF168 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RNF168-2338H Recombinant Human RNF168, GST-tagged E.coli GST
    Human RNF168-30H Recombinant Human RNF168, GST-tagged Wheat Germ GST
    Human RNF168-679H Recombinant Human RNF168 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Rnf168-5551M Recombinant Mouse Rnf168 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish RNF168-10228Z Recombinant Zebrafish RNF168 Mammalian Cell His

    RNF168 involved in several pathways and played different roles in them. We selected most pathways RNF168 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF168 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle NUP50; ANAPC13; TEX12; SMC1B; ANKLE2; SYNE1; SKP1; E2F6; RAD9; DPF1
    Cell Cycle Checkpoints RAD17; RAD9; HTATIP; HIST4H4; CHEK2; HIST3H2BB; HUS1; MCM10; THRSP; CLSPN
    DNA Double Strand Break Response BARD1; UBE2V2; BRE; BRCC3; KDM4B; BABAM1; TP53BP1; EYA4; CHEK2; RNF168
    DNA Double-Strand Break Repair TDP2; EYA3; FUZ; TOPBP1; KDM4B; KDM4A; RBBP8; PPP4R2B; BRE; RAD50
    DNA Repair DDB2; PPP4R2; RHNO1; GPS1; TIMELESS; RAD18; MAD2L2; PPIE; ERCC8; RBBP8
    G2/M Checkpoints BRCC3; RAD9; RAD1; HUS1; TP53BP1; RAD17; BRE; RAD9A; BARD1; BABAM1
    G2/M DNA damage checkpoint RNF168; BABAM1; TP53BP1; UIMC1; BRE; BARD1; BRCC3; FAM175A; THRSP
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) GEN1; RAD51AP1; RNF168; PPP4R2; RAD9; BRE; HUS1; KIAA0146; FUZ; RNF4

    RNF168 has several biochemical functions, for example, K63-linked polyubiquitin binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF168 itself. We selected most functions RNF168 had, and list some proteins which have the same functions with RNF168. You can find most of the proteins on our site.

    Function Related Protein
    K63-linked polyubiquitin binding ZRANB1B; OTUD7B; ZRANB1; UIMC1; IKBKG; TNFAIP3; SQSTM1; TAB2; ZRANB3; SPRTN
    chromatin binding TRP63; HOXC13; GLI3; MECP2; PPARGC1A; AJUBA; LRWD1; CHD7; POU4F2; SKIL
    histone binding PYGO2; HIST1H47; HIST1H4C; BRD1; SUPT6H; DAXX; PRMT6; HIST1H4K; DNAJC2; PKN1
    ligase activity ACSM2; BIRC7; TRIM68; HECTD2; RNF144AA; STUB1; RC3H2; TRIM56; TRIM58; SHRPRBCK1R
    nucleosome binding DNTTIP1; SMARCA5; NOC2L; MUM1; RNF168; RNF169; RNF4; ZNHIT1; ARID1A; L3MBTL1
    protein binding SPRY1; ADAMTS3; LIMK1; CALM2; PCGF3; RBM11; TEAD4; HDAC4; ZKSCAN17; MAP4K1
    ubiquitin binding RBCK1; USP5; USP25; RNF31; FAM125A; NPLOC4; UBAP1; CRY2; PER2; TOM1L1
    ubiquitin-protein transferase activity SIAH1; HUWE1; FBXO30B; HECTD1; RCHY1; MARCH8; RNF125; ZYG11; ARIH1; CMTM2A
    zinc ion binding RNPEP; AIRE; SUV39H1B; GATA1A; TRIM35-24; RNF144B; PEX12; CNBP; RORA; HE1A

    RNF168 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF168 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF168.

    UBB; GTF2F2; UBE2N; UBE2G2; LAPTM5; RNF11; PSMD11; UBR5; TBP; TRIP12; CCDC174; SRCAP; RNF169; FAM45A; RPRD1B; NUB1; TACC3; H2AFX

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