RNF168

  • Official Full Name

    ring finger protein 168, E3 ubiquitin protein ligase
  • Overview

    This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
  • Synonyms

    RNF168;ring finger protein 168, E3 ubiquitin protein ligase;ring finger protein 168;E3 ubiquitin-protein ligase RNF168;FLJ35794;FLJ39749

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • DDK
  • Myc
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
RNF168-2338H Recombinant Human RNF168, GST-tagged E.coli Human GST C-351aa
RNF168-10228Z Recombinant Zebrafish RNF168 Mammalian Cells Zebrafish His
RNF168-679H Recombinant Human RNF168 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
RNF168-1520HCL Recombinant Human RNF168 cell lysate Human Non
RNF168-0038H Recombinant Human RNF168 Protein (Met1-Lys571), N-His-tagged Insect Cells Human His Met1-Lys571
RNF168-0039H Recombinant Human RNF168 Protein (Asn523-Arg565), N-His-tagged E.coli Human His Asn523-Arg565
RNF168-2245H Recombinant Human RNF168 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
RNF168-30H Recombinant Human RNF168, GST-tagged Wheat Germ Human GST
RNF168-4873H Recombinant Human RNF168 protein(1-571aa), His-tagged Insect Cells Human His 1-571aa
Rnf168-5127M Recombinant Mouse Rnf168 Protein (Asn423-Arg565), N-His tagged E.coli Mouse His Asn423-Arg565
Rnf168-5551M Recombinant Mouse Rnf168 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
RNF168-5708H Recombinant Human RNF168 Protein (Met1-Lys571), N-His tagged Mammalian Cells Human His Met1-Lys571
RNF168-6845HF Recombinant Full Length Human RNF168 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 571 amino acids

    Involved Pathway

    RNF168 involved in several pathways and played different roles in them. We selected most pathways RNF168 participated on our site, such as Cell Cycle,Cell Cycle Checkpoints,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF168 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G2/M DNA damage checkpoint BABAM1,FAM175A,THRSP,UIMC1,TP53BP1,BRCC3,BARD1,BRE
    DNA Repair RTEL1,RAD9B,ZBTB32,COPS7B,KDM4A,DDB2,POLI,INO80E,TP53BP1,ERCC8
    G2/M Checkpoints BARD1,THRSP,FAM175A,BRE,RAD17,RAD1,UIMC1,HUS1,RAD9A,RAD9B
    Cell Cycle Checkpoints RAD9B,CDKN1B,UIMC1,CDK5RAP2,BRE,YWHAQ,BABAM1,CDK2,RAD17,CHEK2
    Cell cycle CDC14A,TUBG2,BRE,CDC14B,AKAP9,E2F5,MCM3L,YWHAG,CENPO,ESPL1
    DNA Double Strand Break Response EYA3,UBE2V2,BARD1,SMARCA5,EYA4,EYA2,THRSP,KDM4A,UIMC1,BRE
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) BRCC3,RBBP8,PPP4R2B,TP53BP1,RHNO1,RNF4,EME2,FAM175A,RAD9,TIMELESS
    DNA Double-Strand Break Repair TIMELESS,KDM4A,SMARCA5,PARP2,THRSP,FAM175A,KDM4B,KIAA0146,BRCC3,WRN

    Protein Function

    RNF168 has several biochemical functions, for example, K63-linked polyubiquitin binding,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF168 itself. We selected most functions RNF168 had, and list some proteins which have the same functions with RNF168. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin binding DNAJC2,PER2,UBAP1,D17WSU92E,CRY2,NSFL1C,USP16,IDE,SMAD3,BRAP
    zinc ion binding MMP3,TRIM42,JADE3,QPCTL,ADAMTS8,KDM2BA,KNG1,Alb,ZNF207,LHX1B
    ubiquitin-protein transferase activity FBXO22,RNF213,SHPRH,MUL1A,CBLL1,TRIM13,MIB2,TRIM5,HECW2,FEM1A
    K63-linked polyubiquitin binding ZRANB1,TAB2,RNF169,SQSTM1,SPRTN,ZRANB1B,TNFAIP3,ZRANB3,ATRIP,OTUD7B
    ligase activity TRIM11,MARCH11,FANCL,RTCD1,CPS1,NEURL3,TRAF3,RNF19B,UNKL,CBLL1
    nucleosome binding ZNHIT1,RNF4,MUM1,SMARCA5,RNF169,DNTTIP1,ARID1A,L3MBTL1,NOC2L,HP1BP3
    histone binding SERPINB1A,H3F3A,H2AFX,HIST1H3C,Ctsl,HINFP,PYGO2,NCL,TBL1XR1,HIST1H3H
    chromatin binding EYA3,CITED1,SOX14,MTA1,TTC5,SMC3,NEUROD1,SETD7,SOX9,MEF2C
    protein binding MTMR2,RAB11FIP3,JAK2,ATG13,PIK3CG,TOX4,LACE1,GRM2,HNRNPM,GRIN2A

    Interacting Protein

    RNF168 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF168 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF168.

    UBB;GTF2F2;UBE2N;UBE2G2;LAPTM5;RNF11;PSMD11;UBR5;TBP;TRIP12;CCDC174;SRCAP;RNF169;FAM45A;RPRD1B;NUB1;TACC3;H2AFX

    Resources

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