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Official Full Name ring finger protein 7
Background The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms RNF7; ring finger protein 7; SAG; ROC2; CKBBP1; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; RING-box protein 2; Rbx2; CKII beta-binding protein 1; Regulator of cullins 2; Sensitive to apoptosis gene protein; OTTHUMP00000180644; OTTHUMP00000180645; zinc RING finger protein SAG
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF7-1506H Recombinant Human RNF7 Protein (2-113 aa), His-tagged Yeast His
    Human RNF7-2272HCL Recombinant Human RNF7 293 Cell Lysate HEK293 N/A
    Human RNF7-2286H Recombinant Human RNF7, His-tagged E.coli His
    Human RNF7-670H Recombinant Human RNF7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human RNF7-780H Recombinant Human RNF7 Protein (2-113 aa), GST-tagged E.coli GST
    Mouse RNF7-14354M Recombinant Mouse RNF7 Protein Mammalian Cell His
    Mouse Rnf7-5560M Recombinant Mouse Rnf7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque RNF7-3947R Recombinant Rhesus monkey RNF7 Protein, His-tagged Mammalian Cell His
    Chicken RNF7-2963C Recombinant Chicken RNF7 Mammalian Cell His
    Zebrafish RNF7-2057Z Recombinant Zebrafish RNF7 Mammalian Cell His

    rnf7 involved in several pathways and played different roles in them. We selected most pathways rnf7 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with rnf7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBA1; UBE3B; PIAS1; UBE2M; UBE2NB; FBXW7; PRPF19; CDC23; UBE2D2L; XIAP

    rnf7 has several biochemical functions, for example, NEDD8 transferase activity, copper ion binding, cullin family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by rnf7 itself. We selected most functions rnf7 had, and list some proteins which have the same functions with rnf7. You can find most of the proteins on our site.

    Function Related Protein
    NEDD8 transferase activity UBE2F; RNF7; RBX1; UBE2M
    copper ion binding LOXL2A; LOX; MT3; P2RX4; LOXL3B; S100U; ATP7B; ABP1; ANG; PARK7
    cullin family protein binding ANAPC11; KCTD17; CCDC22; DCUN1D4; DCUN1D2; DCUN1D1; TCHP; DCUN1D3; DCUN1D2B; PARK2
    protein binding ZFPL1; BCL6; TMX3; JMJD7; GLE1; NUP133; CISH; FBXO17; TXNIP; C1QA
    ubiquitin protein ligase activity MARCH1; NEURL3; PARK2; ARIH1; MGRN1; SIAH1A; UBE2C; HERC6; RNF165; MED24
    zinc ion binding TRIM35-31; XIAP; ING5A; YY1; BLVRA; KDM2B; GATA6; RXRAA; MICAL1; PHC2A

    rnf7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rnf7 here. Most of them are supplied by our site. Hope this information will be useful for your research of rnf7.

    CUL5; IKBKG; vif; RAB40C; ASB12; ASB2; ASB7; ASB6; ASB1; UBE2D1

    Zhou, WH; Xu, J; et al. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. ONCOTARGET 5:6746-6755(2014).
    Sahun, I; Marechal, D; et al. Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy of a Genomic Region Implicated in Down Syndrome. GENETICS 197:899-912(2014).

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