RNASEL
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Official Full Name
ribonuclease L (2,5-oligoisoadenylate synthetase-dependent)
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Overview
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. -
Synonyms
RNASEL; ribonuclease L (2,5-oligoisoadenylate synthetase-dependent); PRCA1, prostate cancer 1 , RNS4; 2-5A-dependent ribonuclease; 2 5A dependent ribonuclease; 2 5 oligoisoadenylate synthetase dependent; 2-5A-dependent RNase; DKFZp781D08126; Interferon induced 2 5A dependent RNase; MGC104972; MGC133329; PRCA 1; PRCA1; Ribonuclease 4; Ribonuclease L (2 5-oligoisoadenylate synthetase dependent); Ribonuclease L; Ribonuclease4; RibonucleaseL; RNS 4; RNS4; RNase L; OTTHUMP00000033148; interferon-induced 2-5A-dependent RNase; 2,5-oligoisoadenylate synthetase-dependent;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- Myc|DDK
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- RNASEL Related Articles
- RNASEL Related Gene Family
RNASEL involved in several pathways and played different roles in them. We selected most pathways RNASEL participated on our site, such as Hepatitis C, Influenza A, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNASEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | PIK3CD;GRB2;IFN-a;CLDN10;IFNB1;IKBKE;CLDN17;TNF;PPARA |
| Influenza A | DNAJC3;CCL5;BLA;KPNA2;HSPA2;Ifna15;CASP1;MAP2K6;IKBKB |
| Herpes simplex infection | HNRPKL;IFNAR2;ARNTL;TNF;PVRL2;FASLG;IL12B;TAF9B;TRAF1 |
RNASEL has several biochemical functions, for example, ATP binding, RNA binding, endoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNASEL itself. We selected most functions RNASEL had, and list some proteins which have the same functions with RNASEL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PANK1A;KIT;PRKCH;LYN;IDE;BMP2K;SMC4;MYH1;CAMK2A |
| RNA binding | ADAD2;HNRNPL;EIF4E1B;AGFG1A;HNRNPL2;RPL18;EIF2S1A;RBM18;DDX17 |
| endoribonuclease activity | CPSF3;ERN1;RNASEKA;DROSHA;DICER1;RCL1;TSN;ENDOU;RNASEK |
| metal ion binding | GALNT6;ASH2L;ZFYVE27;RXFP1;STK24;ZNRF2A;ZFYVE16;TROVE2;MCCC1 |
| protein binding | LARP1;VPS29;UTP23;PLEKHM1;USP10;SLC6A20B;C17orf81;CHD;ZBTB2 |
| protein kinase activity | HIPK3A;DYRK1AA;GSG2;NLK2;TESK2;MAP2K2A;CAMK2D1;ROCK2B;STK26 |
| rRNA binding | ERAL1;RPS11;RPL23A;MRPS7;PPAN;RPS5;MTERFD2;DDX21;RNASEL |
| ribonucleoprotein complex binding | PRMT7;TIMM50;ITCH;SRP54A;PQBP1;SECISBP2;PIGC;PES;PRPF31 |
RNASEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNASEL here. Most of them are supplied by our site. Hope this information will be useful for your research of RNASEL.
IQGAP1; KIF23
- Q&As
- Reviews
Q&As (5)
Ask a questionSome studies have suggested that dietary factors, such as vitamin E and selenium, may influence RNASEL activity.
RNASEL expression and activity are regulated by various factors, including cytokines and viral infections.
Potential side effects may include alterations in immune response and potential impact on RNA degradation processes.
Yes, variations in the RNASEL gene have been linked to differences in the response to antiviral therapies.
Some studies have suggested a potential link between RNASEL protein and autoimmune diseases, but more research is needed to fully understand this relationship.
Customer Reviews (3)
Write a reviewI am certain that the RNASEL protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.
The excellent technical support provided by the manufacturer can solve my problem.
Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the RNASEL protein consistently delivers exceptional performance and precise outcomes.
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