ROCK2

  • Official Full Name

    Rho-associated, coiled-coil containing protein kinase 2

  • Overview

    The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
  • Synonyms

    ROCK2; Rho-associated, coiled-coil containing protein kinase 2; ROCK-II; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect cells
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ROCK2-26H Active Recombinant Human ROCK2 protein, GST-tagged Insect Cell GST
Human ROCK2-30955TH Recombinant Human ROCK2 N/A
Human ROCK2-672H Recombinant Human ROCK2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ROCK2-421H Recombinant Human ROCK2, GST-tagged, Active Sf9 Insect Cell GST
Human ROCK2-712H Recombinant Human ROCK2, GST-His Sf9 Insect Cell GST
Human ROCK2-1878H Recombinant Human ROCK2 protein, His & T7-tagged E.coli His/T7 Leu904~Gly1140 (Accession # O75116)
Human ROCK2-2255HCL Recombinant Human ROCK2 293 Cell Lysate HEK293 N/A
Human ROCK2-337H Active Recombinant Human ROCK2 Protein, GST-Tagged E. coli GST 1-181 aa
Human ROCK2-9069HFL Recombinant Full Length Human ROCK2 protein, Flag-tagged Mamanlian cells Flag
Human ROCK2-1879H Active Recombinant Human ROCK2 Protein, His-tagged Insect cells His
Human ROCK2-6704H Recombinant Human ROCK2 Protein (Glu907-Gly1140), N-His tagged E.coli N-His Glu907-Gly1140
Human ROCK2-1165H Recombinant Human ROCK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Rock2-5568M Recombinant Mouse Rock2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ROCK2-37M Recombinant Active Mouse ROCK2 Protein (5-554), N-His-tagged Sf9 insect cells N-His 5-554
Mouse Rock2-2025M Recombinant Mouse Rock2 Protein, His-tagged E.coli N-His Leu904-Gly1140
Rat Rock2-2026R Recombinant Rat Rock2 Protein, His-tagged E.coli N-His Leu904-Gly1140
Rhesus Macaque ROCK2-3952R Recombinant Rhesus monkey ROCK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ROCK2-3769R Recombinant Rhesus Macaque ROCK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ROCK2-3769R-B Recombinant Rhesus Macaque ROCK2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ROCK2 Related Articles
  • ROCK2 Related Research Area
  • ROCK2 Related Signal Pathway

ROCK2 involved in several pathways and played different roles in them. We selected most pathways ROCK2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwaySLC8A1;ATP1A1;ATP1B4;ATP1B3;NPR2;ATP2B1;ROCK1;AKT2;RAF1
cAMP signaling pathwayNPR1;RYR2;PDE4B;PIK3R1;RRAS2;GRIA3;PDE4C;VAV1;CALM1
Chemokine signaling pathwayGNG10;CCL24;PRKACG;AKT2;CCL23;IL-8;CCR6;GM2506;CRKL
Sphingolipid signaling pathwayGNAQ;FYN;SPTLC1;ASAH2;RAC1;PRKCB;MAP2K2;SGPP2;SGPL1
Vascular smooth muscle contractionPRKCDA;MYL9A;AGTR1A;PPP1R12C;PLA2G10;CALM3A;CALML3;CALML5;PLA2G2A
Wnt signaling pathwayMAPK8A;RAC3B;RAC1A;MYCB;TP53;NFATC2;TCF7L2;CAMK2B;WNT3A
Axon guidanceWDR83;NEFLB;JAK1;LIMK1;PPP3CA;NFATC3;Unc5b;SCN3A;ACTR2B
Focal adhesionPIK3R3B;ITGA2B;EGFRA;PTK2;MYLPFB;ARHGAP5;PDGFAB;LAMB3;DIAPH1
Platelet activationPLA2G4D;ITGB3;PTGS1;GNAS;MAPK11;TLN1;LCP2;MYLK;SYK
Leukocyte transendothelial migrationCLDN17;BCAR1;CLDN9;CLDN11;VAV1;ROCK1;ITGAL;CLDN15;TXK
Regulation of actin cytoskeletonRHOAD;PIK3CD;PAK2A;RAC3A;ARPC5LB;GSNA;ARHGEF1;BRAF;PTK2
Oxytocin signaling pathwayITPR3;MYLK4;ELK1;KCNJ14;CALM1;CACNG4;FOS;PRKAG3;MYLK3
Pathogenic Escherichia coli infectionTUBA3C;TUBB;ACTB;KRT18;TUBA3D;TUBA1A;TUBA8;ABL1;OCLN
ShigellosisNFKBIB;MAD2L2;RELA;PFN3;MAPK12;NFKBIA;PFN2;ITGB1;NFKB1
Salmonella infectionKLC1A;CXCL1;MAPK14B;RAC1B;MAPK8B;FLNB;KLC1B;CASP1;PKN3
Pathways in cancerCCNA1;PLD1;GRB2;GNGT1;Pdgfa&Pdgfb;SLC2A1;EP300;GNG10;WNT10B
Proteoglycans in cancerWNT7A;HGF;TLR4;RDX;MAP2K1;PXN;PRKCA;NANOG;LUM

ROCK2 has several biochemical functions, for example, ATP binding, Rho GTPase binding, Rho-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK2 itself. We selected most functions ROCK2 had, and list some proteins which have the same functions with ROCK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGRK5;DDX4;NTRK2;CAMK1GB;STK19;PDPK1B;ILF2;GMPS;MAPK8A
Rho GTPase bindingLRRK2;AKAP13;DOCK10;PFN1;CDC42BPB;DAAM1;INF2;FLNA;DIAP3
Rho-dependent protein serine/threonine kinase activity
metal ion bindingYY1B;SP5;COX5B;CTDSPL;BRD1B;ZNF131;ATP13A1;CLCA4;OBSCN
poly(A) RNA bindingMKI67IP;HIST1H4J;RPS15;RPL10L;RBM38;FYTTD1;DHX38;PTBP2;IGF2BP2
protein bindingNRBP1;SEC22B;FAM82A2;RBBP8;GRB10;EFHC2;NDUFB9;PHF16;MED24
protein serine/threonine kinase activityPRKCD;STK16;SGK2A;STK39;MAPK8A;SMOK3B;CDC42BPA;PKN1;AKT1
structural molecule activityKRTAP11-1;COL18A1;CLDN5B;KRTT1C19E;CLDN10B;KRT1-C5;CLTCB;KRT27;LMNB1

ROCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK2.

NFKBIA; PPP1R14B; 15777285; STK16; NCL; IKBKE; purvalanol b; STAU1; Rock1; SNW1; FLOT2; N; CDC5L

Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
Huang, P; Wang, J; et al. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. MOLECULAR MEDICINE REPORTS 6:662-666(2012).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Discuss the role of ROCK2 in smooth muscle contraction and vascular tone. 03/24/2022

ROCK2 is a key regulator of smooth muscle contraction, influencing vascular tone by phosphorylating myosin light chain and promoting actin-myosin interaction.

Describe the molecular crosstalk between ROCK2 and other signaling pathways. 08/07/2021

ROCK2 interacts with various signaling pathways, including Wnt, PI3K/Akt, and MAPK pathways, forming a network that regulates cell survival, proliferation, and differentiation.

How does ROCK2 contribute to the regulation of cell cycle progression? 12/04/2020

ROCK2 can influence the cell cycle by regulating cyclin-dependent kinase activity and promoting the phosphorylation of proteins involved in cell cycle checkpoints.

What are the implications of ROCK2 in cell migration and invasion? 03/18/2019

ROCK2 is involved in the regulation of cell migration and invasion by controlling actin dynamics and focal adhesion turnover, influencing processes like metastasis in cancer.

Discuss the role of ROCK2 in the regulation of the actin cytoskeleton. 06/11/2018

ROCK2 phosphorylates various downstream targets, such as myosin light chain, leading to actin-myosin contraction and the reorganization of the actin cytoskeleton.

Customer Reviews (3)

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Reviews
08/19/2021

    Swift and hassle-free delivery ensured our experiments stayed on track.

    01/13/2020

      Efficient customer service provided valuable insights for our decision-making.

      07/06/2019

        Reliable and precise—this recombined protein never disappoints.

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