ROCK2
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Official Full Name
Rho-associated, coiled-coil containing protein kinase 2
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Overview
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008] -
Synonyms
ROCK2; Rho-associated, coiled-coil containing protein kinase 2; ROCK-II; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
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- Insect Cell
- Insect cells
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- Sf9 insect cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ROCK2 Related Articles
- ROCK2 Related Research Area
- ROCK2 Related Signal Pathway
ROCK2 involved in several pathways and played different roles in them. We selected most pathways ROCK2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | PPP1R12A;PIK3R2;ATP1B2;GUCY1A3;NFATC4;PPP3CB;PIK3R1;NPPB;MYLK4 |
| cAMP signaling pathway | NFKBIA;PDE3A;RRAS2;LOC100328615;CAMK2B;GNAI2;RHOA;AMH;HCN4 |
| Chemokine signaling pathway | CXCR4;CCL23;GRK4;CCL6;GSK3A;CCL5;SHC2;STAT1;CXCL6 |
| Sphingolipid signaling pathway | CERS4;RHOA;MAPK3;PLCB2;SGMS2;MAPK1;BAX;PRKCZ;LASS2 |
| Vascular smooth muscle contraction | ACTG2;ADCY1B;GNAQ;PPP1CB;MAP2K2B;ROCK2;KCNMB4;PPP1CAB;MAP2K2A |
| Wnt signaling pathway | BAMBI;WNT5B;DKK1B;PPARD;CAMK2B1;DVL3A;PRKACA;RAC1B;FBXW11B |
| Axon guidance | CFL2;RGMB;NEFLB;GSK3B;ACTR3;SEMA4A;SPTA1;EFNA1B;PLXNB2 |
| Focal adhesion | PAK2A;BAD;MYL5;ELK1;CDC42L;PDGFC;VTN;ITGA6;ITGB7 |
| Platelet activation | MAPK3;PLA2G4D;AKT2;FERMT3;ITPR1;F2R;GUCY1B3;GP1BA;RAP1B |
| Leukocyte transendothelial migration | MMP2;MYL12A;MMP9;VCAM1;CLDN11;CLDN2;CLDN6;CD99;CDC42 |
| Regulation of actin cytoskeleton | FGFR1;INSRR;MAPK1;PAK6B;RAF1A;FGF13A;MAP2K1;GSNA;FGF2 |
| Oxytocin signaling pathway | EEF2K;PPP3R1;PRKAB1;CALM1;GNAI1;ACTG1;NFATC3;PLCB3;MAP2K5 |
| Pathogenic Escherichia coli infection | YWHAZ;WASL;ITGB1;LY96;HCLS1;OCLN;CLDN1;ROCK2;TLR5 |
| Shigellosis | ELMO3;PFN3;VCL;DIAPH1;WASF1;MAPK12;IKBKB;FBXW11;ACTG1 |
| Salmonella infection | CXCL8B.3;ACTG1;NOS2A;MAPK9;RHOGC;RELA;MYD88;KLC4;CASPA |
| Pathways in cancer | PTGS2;RUNX1T1;RALGDS;NCOA4;WNT2B;Pdgfa&Pdgfb;TRAF3;AGTR1A;WNT2 |
| Proteoglycans in cancer | HSPG2;RAC1;CAV3;PPP1CC;FLNC;PDPK1;MDM2;FGFR1;PLCE1 |
ROCK2 has several biochemical functions, for example, ATP binding, Rho GTPase binding, Rho-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK2 itself. We selected most functions ROCK2 had, and list some proteins which have the same functions with ROCK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | STK38L;VARS;ADK;UBE2D3;DDX19B;ATP11A;TAE1;KIF2C;MYLK |
| Rho GTPase binding | ROCK2;DOCK9;ARHGEF2;CSDA;FLNA;CDC42BPB;PARD6A;DAAM1B;KIF3B |
| Rho-dependent protein serine/threonine kinase activity | |
| metal ion binding | GDPD3;PRKCQ;HMOX2;CHORDC1;CELA1;ELMSAN1A;ZFP667;SMAD4;Amy1 |
| poly(A) RNA binding | ENO1;RPS23;HIST1H4N;DDX5;SSRP1;PRPF31;YTHDF3;MPHOSPH10;C1orf131 |
| protein binding | MRPL48;PIK3R4;SENP7;PTCRA;OTUD7B;LYSMD1;RBFA;HNRNPH3;DIABLO |
| protein serine/threonine kinase activity | CLK2;PRKCHB;CSNK1A1;RIOK2;CDC42BPA;MAPK14;PRKY;NEK1;STK31 |
| structural molecule activity | KRT4;KRTAP3-2;KRT35;CLDN3;ROCK2;KLHL3;ASPH;CLDNF;SPRR1B |
ROCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK2.
NFKBIA; PPP1R14B; 15777285; STK16; NCL; IKBKE; purvalanol b; STAU1; Rock1; SNW1; FLOT2; N; CDC5L
- Q&As
- Reviews
Q&As (5)
Ask a questionROCK2 is a key regulator of smooth muscle contraction, influencing vascular tone by phosphorylating myosin light chain and promoting actin-myosin interaction.
ROCK2 interacts with various signaling pathways, including Wnt, PI3K/Akt, and MAPK pathways, forming a network that regulates cell survival, proliferation, and differentiation.
ROCK2 can influence the cell cycle by regulating cyclin-dependent kinase activity and promoting the phosphorylation of proteins involved in cell cycle checkpoints.
ROCK2 is involved in the regulation of cell migration and invasion by controlling actin dynamics and focal adhesion turnover, influencing processes like metastasis in cancer.
ROCK2 phosphorylates various downstream targets, such as myosin light chain, leading to actin-myosin contraction and the reorganization of the actin cytoskeleton.
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