ROCK2 Protein

ROCK2

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ROCK2

Official Full Name Rho-associated, coiled-coil containing protein kinase 2
Background The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Synonyms ROCK2; Rho-associated, coiled-coil containing protein kinase 2; ROCK-II; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ROCK2-26H Recombinant Human ROCK2 protein, GST-tagged Insect Cell GST
    Human ROCK2-1165H Recombinant Human ROCK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ROCK2-1878H Recombinant Human ROCK2 protein, His & T7-tagged E.coli His/T7
    Human ROCK2-1879H Recombinant Human ROCK2 Protein, His-tagged Insect cells His
    Human ROCK2-2255HCL Recombinant Human ROCK2 293 Cell Lysate HEK293 N/A
    Human ROCK2-30955TH Recombinant Human ROCK2 N/A
    Human ROCK2-337H Recombinant Human ROCK2 Protein, GST-Tagged E. coli GST
    Human ROCK2-421H Recombinant Human ROCK2, GST-tagged, Active Sf9 Insect Cell GST
    Human ROCK2-672H Recombinant Human ROCK2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ROCK2-712H Recombinant Human ROCK2, GST-His Sf9 Insect Cell GST
    Mouse Rock2-5568M Recombinant Mouse Rock2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque ROCK2-3952R Recombinant Rhesus monkey ROCK2 Protein, His-tagged Mammalian Cell His

    ROCK2 involved in several pathways and played different roles in them. We selected most pathways ROCK2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway PPP3R2; IRS2; PPP3CA; ATP2B1; PLN; BDKRB2; SLC8A2; NFATC3; PLCB3; BAD
    cAMP signaling pathway NFATC1; F2R; ORAI1; CALML3; ATP1B4; CAMK4; PDE4A; CALM2; PDE4C; GRIN2D
    Chemokine signaling pathway PLCB4; SHC2; PRKCZ; PRKACB; CCL25; CCL21; PREX1; AMCF-II; RAF1; GNAI3
    Sphingolipid signaling pathway ASAH2; PIK3R5; PPP2R2D; MAP2K1; MAPK11; PPP2CB; FYN; RAF1; PRKCE; PLD1
    Vascular smooth muscle contraction CALD1; ROCK1; ADRA1BB; MYL9A; PLA2G2F; CACNA1DA; CACNA1C; PLA2G3; MYLK4; PPP1CAA
    Wnt signaling pathway WNT16; NFATC2; CAMK2G; CAMK2D2; DAAM1B; MAPK8B; FZD7A; SFRP4; CAMK2B1; TLE3A
    Axon guidance COL9A1A; CDK5R1B; CLASP1; SLIT1; DUSP5; EPHB1; PEBP1; MAPK1; EFNA3; DLG3
    Focal adhesion COL5A2; ACTB2; SEPP1; PPP1CBL; MYLPFA; MYLK3; DOCK1; PDGFAA; HGF; PIK3R1
    Platelet activation PLA2G4F; ARHGEF1; NOS3; PRKG2; STIM1; GP6; COL27A1; MYLK; MAPK13; PLA2G4D
    Leukocyte transendothelial migration PIK3CD; PTK2B; MAPK12; NIPAL1; PIK3CG; VCL; MYL10; AASS; CLDN5; MSN
    Regulation of actin cytoskeleton ITGB5; CFL2L; SLC9A1; DIAP3; FGF5; PTK2AA; ACTG1; GNA12; RHOAB; PFN1
    Oxytocin signaling pathway PIK3CG; PPP1CC; TRPM2; PPP3CB; ACTG1; CAMKK2; MYLK4; FOS; EEF2K; PLCB3
    Pathogenic Escherichia coli infection CTTN; OCLN; NCL; RHOA; EZR; TUBB6; WASL; CLDN1; TUBB; ACTB
    Shigellosis CDC42; IKBKG; RELA; ELMO2; WAS; MAPK12; HCLS1; NFKBIB; MAD2L2; WASF1
    Salmonella infection ACTB2; KLC1B; MAPK12; FLNA; PFN1; DYNC2H1; RHOGD; ROCK2A; KLC1; TLR5
    Pathways in cancer FZD8; RALB; PRKCG; IKBKG; BIRC7; SMAD3; GNGT2; TRAF3; FZD1; PTGER1
    Proteoglycans in cancer TWIST1; MAP2K1; ARAF; WNT7B; PTPN11; CCND1; Ctsl; MAPK3; PPP1R12C; ACTG1

    ROCK2 has several biochemical functions, for example, ATP binding, Rho GTPase binding, Rho-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK2 itself. We selected most functions ROCK2 had, and list some proteins which have the same functions with ROCK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding IDH3G; EPHA4A; H1FNT; NMNAT1; MATK; CDKL4; SUCLG1; CKB; NPR1A; HELZ
    Rho GTPase binding DAAM1B; ROCK2B; DOCK11; ARHGEF16; LRRK2; INF2; PARD6A; ANTXR2A; DIAP3; DOCK10
    Rho-dependent protein serine/threonine kinase activity ROCK2
    metal ion binding ADAMTS7; UGP2; ZNF577; ACMSD; CYP2C38; ANTXR1; ZNF167; ZC4H2; BRCC3; ZMYM2
    poly(A) RNA binding CNBP; ALKBH5; RC3H2; PUS1; KIAA1429; RPL23; TRA2A; RBM10; NMD3; YTHDF3
    protein binding DPP4; AP1G2; RINL; ACMSD; ANK1; KDM4A; SMNDC1; ZSCAN16; WIF1; APBB3
    protein serine/threonine kinase activity ACVR2AA; BMPR1BB; RIOK1; STK36; STK10; PRKCHA; AKT2L; PLK3; MAP3K9; TLK1B
    structural molecule activity CAV1; CTNNA1; PRR9; DESMA; MATR3; SPRR2G; SPRR3; NEFMA; SEMG2; NEFMB

    ROCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK2.

    NFKBIA; PPP1R14B; 15777285; STK16; NCL; IKBKE; purvalanol b; STAU1; Rock1; SNW1; FLOT2; N; CDC5L

    Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
    Huang, P; Wang, J; et al. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. MOLECULAR MEDICINE REPORTS 6:662-666(2012).

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