RP2
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Official Full Name
retinitis pigmentosa 2 (X-linked recessive)
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Overview
The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows;homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal;degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin;isoforms followed by progressive cell death. -
Synonyms
RP2; retinitis pigmentosa 2 (X-linked recessive); protein XRP2; NME10; TBCCD2; DELXp11.3; KIAA0215; Retinitis pigmentosa 2 (X linked recessive); Retinitis pigmentosa 2; RP 2; TBCCD 2; XRP2; XRP2 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- RP2 Related Articles
RP2 involved in several pathways and played different roles in them. We selected most pathways RP2 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with RP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | PKD1;BBS5;IFT22;TTC30A1;TUBB4B;MARK4;CCDC41;DYNLL2A;HSPB11 |
| Cargo trafficking to the periciliary membrane | PKD1;EXOC3;EXOC6;BBS7;LZTFL1;ARF4A;CYS1;ARF4;TCP1 |
| Organelle biogenesis and maintenance | KIF17;EXOC5;MRPS26;CNGA2;CHCHD1;PKD1;CYS1;WDR34;TNPO1 |
| Trafficking of myristoylated proteins to the cilium | UNC119.1;NPHP3;UNC119B;CYS1;RP2;ARL3 |
RP2 has several biochemical functions, for example, GTP binding, GTPase activator activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RP2 itself. We selected most functions RP2 had, and list some proteins which have the same functions with RP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | EHD1A;GUCY1A3;RAB11A;RHOGC;RABL5;RASD2;SEPT4A;ARL3L1;MXA |
| GTPase activator activity | TBC1D10C;RINL;DAB2IPB;ARHGEF19;RABEP2;RACGAP1;ARHGAP12;ARHGAP11A;TBC1D14 |
| actin binding | XIRP2;PARVG;PLEC;MYO3B;PARK2;CORO1A;VPS16;ACTR2B;DIAP3 |
| protein binding | CD70;CYTH1;PTK7;VPS28;ZCCHC10;HIST2H3C;KLHL22;CRHR2;SSU72 |
| unfolded protein binding | PFDN4;CLGN;SERPINH1;HSPE1;PFDN5;CLPX;CRYAB;DNAJB4;TAPBP |
RP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RP2.
ARL3
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