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RPGRIP1L

Official Full Name

RPGRIP1-like
Overview

The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause of Joubert syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

RPGRIP1L; RPGRIP1-like; protein fantom; CORS3; fantom homolog; FTM; JBTS7; KIAA1005; Meckel syndrome; type 5; MKS5; NPHP8; nephrocystin 8; nephrocystin-8; RPGRIP1-like protein; RPGR-interacting protein 1-like protein; DKFZp686C0668;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	RPGRIP1L-14399M	Recombinant Mouse RPGRIP1L Protein	Mammalian Cell	His	Inquiry
Mouse	RPGRIP1L-7716M	Recombinant Mouse RPGRIP1L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	RPGRIP1L-7716M-B	Recombinant Mouse RPGRIP1L Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	RPGRIP1L-3967R	Recombinant Rhesus monkey RPGRIP1L Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	RPGRIP1L-3784R	Recombinant Rhesus Macaque RPGRIP1L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	RPGRIP1L-3784R-B	Recombinant Rhesus Macaque RPGRIP1L Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	RPGRIP1L-8097Z	Recombinant Zebrafish RPGRIP1L	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

RPGRIP1L involved in several pathways and played different roles in them. We selected most pathways RPGRIP1L participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Hedgehog off state, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPGRIP1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Anchoring of the basal body to the plasma membrane	B9D2;IQCB1;CEP164;CEP76;CEP290;TTBK2;CEP135;NDE1;AKAP9
Assembly of the primary cilium	C11orf60;CC2D2A;WDR34;TMEM67;FGFR1OP;CEP63;CEP290;CNGA5;NPHP3
Hedgehog off state	RPGRIP1L;TULP3;WDR35;IFT52;IFT122;BBS13;MKS1;TTC21B;IFT88
Hedgehog on state	EVC;MKS1;IFT172;CDON;KIF3A;GPR161;EVC2;BOC;RPGRIP1L
Organelle biogenesis and maintenance	BBS5;HSPB11;TTC30B;UNC119.1;MRPL52;MRPL37;IFT22;RABL5;MRPL45
Signal Transduction	PRICKLE1;IFT172;RGS10;RHOT1B;OBSCN;METAP2A;RAMP2;WDR35;OXGR1A.1
Signaling by Hedgehog	CDON;GAS8;IFT52;BOC;SCUBE2;IFT122;GPR161;IFT88;RPGRIP1L

RPGRIP1L has several biochemical functions, for example, protein binding, thromboxane A2 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPGRIP1L itself. We selected most functions RPGRIP1L had, and list some proteins which have the same functions with RPGRIP1L. You can find most of the proteins on our site.

Function	Related Protein
protein binding	CRYGC;TRIM43;RAB26;PARP9;GTPBP2;HDAC1;CBX8;PAGE2;RFC4
thromboxane A2 receptor binding

RPGRIP1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPGRIP1L here. Most of them are supplied by our site. Hope this information will be useful for your research of RPGRIP1L.

Nphp4; Iqcb1; Ddx5; Ambra1; Ubr4; Lrp2; Ccdc171; Aldoart1; Cad; Gcn1l1; Dsp; a2cf96_mouse; Dpysl2; Stxbp1; Utrn