RPL5
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Official Full Name
ribosomal protein L5 -
Overview
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] -
Synonyms
RPL5;ribosomal protein L5;L5;DBA6;MSTP030;60S ribosomal protein L5
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
RPL5 involved in several pathways and played different roles in them. We selected most pathways RPL5 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | MRPS14,RPS4X,RPL12,MRPS18C,RPLP2L,RPL21,MRPL36,RPL3L,RPS3A,RPS27.1 |
Protein Function
RPL5 has several biochemical functions, for example, 5S rRNA binding,RNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL5 itself. We selected most functions RPL5 had, and list some proteins which have the same functions with RPL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | ZNF385D,RNMTL1B,SRSF9,RPL27A,RPS3A,DKC1,ZFP385C,RPS4Y1,KIAA0430,CNOT4B |
| poly(A) RNA binding | SEC61B,PURB,PTRH1,C1orf53,RTCA,KIAA0020,GFM1,RC3H2,FAM32A,SFPQ |
| structural constituent of ribosome | RPS13,MRPS9,MRPS36,RPL37A,MRPS16,MRPL18,RPL10,RPS27A,RPS9,MRPS22 |
| protein binding | NFE2,CCDC85B,LRP5,ARHGEF15,H2-KE2,MMS22L,MAGI2,SERPINF2,SCG5,TXLNB |
| 5S rRNA binding | MRPL18,RPL5A,TST,RPL5B |
Interacting Protein
RPL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL5.
MDM2;Dcc;DCC;CSNK2B;VCAM1
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