RPS3
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Official Full Name
ribosomal protein S3 -
Overview
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] -
Synonyms
RPS3;ribosomal protein S3;S3;40S ribosomal protein S3;IMR-90 ribosomal protein S3
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- Fruit Fly
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- GST
- SUMO
- Avi
- Fc
Involved Pathway
RPS3 involved in several pathways and played different roles in them. We selected most pathways RPS3 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL17,RPS21,RPL21,RPS4Y1,FAU,MRPL12,FAUA,MRPL28,RPL27A,RPS16 |
Protein Function
RPS3 has several biochemical functions, for example, NOT DNA N-glycosylase activity,DNA binding,DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS3 itself. We selected most functions RPS3 had, and list some proteins which have the same functions with RPS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| small ribosomal subunit rRNA binding | MRPS6,UTP23,CIRBP,RPS13,RPS14,NSUN4,MRPS11 |
| supercoiled DNA binding | HMGB2,PSIP1,HMGB1 |
| NF-kappaB binding | PSMA6,AP1S2,HDAC2,FAF1,CPNE1,HIF1AN,EP300,CDKN2A,CDK5RAP3,HDAC1 |
| Hsp70 protein binding | PARK2,PPEF2,TSACC,ST13,DNAJC2,CDK1,STUB1,MVD,STIP1,ERN1 |
| transcription factor binding | ZEB1,NKX3,DDIT3,MAFB,CEBPB,PPP1R13L,THRA,GTF2A1,IFT172,SP100 |
| oxidized purine nucleobase lesion DNA N-glycosylase activity | OGG1 |
| enzyme binding | BCR,TP53,SORT1,PDCD2,PTPLA,HDAC1,RPA2,HSPA1A,SCNM1-PS,TMBIM6 |
| SUMO binding | CBX4,USPL1,TOLLIP,PML,USP25,TDG,HERC2 |
| microtubule binding | KATNB1,REEP1,FAM83D,KIF18A,MAP1S,CAMSAP1A,TRIM54,FNTA,FAM154A,CCDC88A |
Interacting Protein
RPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS3.
RELA;MDM2;NFKBIA
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References
- Choi, SH; Kim, SY; et al. Immunohistochemical studies of human ribosomal protein s3 (rpS3). JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 39:208-215(2006).
- Ahn, EH; Kim, DW; et al. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. FREE RADICAL BIOLOGY AND MEDICINE 55:36-45(2013).
- HANDA, H; GUALBERTO, JM; et al. CHARACTERIZATION OF THE MITOCHONDRIAL ORFB GENE AND ITS DERIVATIVE, ORF224, A CHIMERIC OPEN READING FRAME SPECIFIC TO ONE MITOCHONDRIAL GENOME OF THE POLIMA MALE-STERILE CYTOPLASM IN RAPESEED (BRASSICA-NAPUS L). CURRENT GENETICS 28:546-552(1995).
