RPS3 Protein

RPS3

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RPS3

Official Full Name ribosomal protein S3
Background Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Synonyms RPS3; ribosomal protein S3; S3; 40S ribosomal protein S3; IMR-90 ribosomal protein S3;
    • Species :
    • Chicken
    • Fruit Fly
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • His-SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RPS3-2420H Recombinant Human Ribosomal Protein S3 E.coli N/A Inquiry
    Human RPS3-2421H Recombinant Human Ribosomal Protein S3, His-tagged E.coli His Inquiry
    Human RPS3-29970TH Recombinant Human RPS3 E.coli N/A Inquiry
    Human RPS3-30468TH Recombinant Human RPS3 protein, His-tagged E.coli His Inquiry
    Human RPS3-480H Recombinant Human RPS3, GST-tagged E.coli GST Inquiry
    Human RPS3-6890H Recombinant Human Ribosomal Protein S3, His-tagged E.coli His Inquiry
    Mouse RPS3-14489M Recombinant Mouse RPS3 Protein Mammalian Cell His Inquiry
    Rat RPS3-5168R Recombinant Rat RPS3 Protein Mammalian Cell His Inquiry
    Rhesus Macaque RPS3-4025R Recombinant Rhesus monkey RPS3 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken RPS3-2532C Recombinant Chicken RPS3 Mammalian Cell His Inquiry
    Zebrafish RPS3-11372Z Recombinant Zebrafish RPS3 Mammalian Cell His Inquiry
    Human RPS3-563HCL Recombinant Human RPS3 lysate HEK293 N/A Inquiry
    Human RPS3-1106H Recombinant Human RPS3 protein, His-tagged E.coli His Inquiry
    Human RPS3-3450H Recombinant Human RPS3 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Rhesus Macaque RPS3-3842R Recombinant Rhesus Macaque RPS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rat RPS3-4827R Recombinant Rat RPS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Mouse RPS3-7788M Recombinant Mouse RPS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Fruit Fly RPS3-2481F Recombinant Fruit Fly RPS3 Protein (1-246 aa), His-tagged E.coli His Inquiry

    RPS3 involved in several pathways and played different roles in them. We selected most pathways RPS3 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome UBA52; MRPS7; RPS2; RPL38; RPL36; RPL8; RPS27L; RPL29; MRPL33; RPS27

    RPS3 has several biochemical functions, for example, NOT DNA N-glycosylase activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS3 itself. We selected most functions RPS3 had, and list some proteins which have the same functions with RPS3. You can find most of the proteins on our site.

    Function Related Protein
    NOT DNA N-glycosylase activity RPS3
    DNA binding H1M; MCM6L; TOP3B; HIST1H4A; HOMEZB; ZNF738; MCM3L; MYCS; ZNF565; SPRTN
    DNA-(apurinic or apyrimidinic site) lyase activity HMGA1B; NTHL1; APLF; RPS3; ALKBH1; APEX1; HMGA2; HMGA1A; NEIL1; APEX2
    Hsp70 protein binding DNAJA1; ERN1; STIP1; METTL21A; L7RN6; RPS3; PPEF2; DNAJC2; PACRG; C11orf73
    Hsp90 protein binding PPEF2; USP19; PACRG; HIF1A; FKBP6; AHR; NASP; ARNTL; CDC37; CSNK2A1
    NF-kappaB binding PSMA6; NFKBIA; FOXP3; RPS3; DNAJA3; ANXA4; BCL10; AP1S2; HDAC2; HDAC1
    RNA binding NANOS3; ENDOU2; SNRPA; HNRNPH3; KIAA0430; JAKMIP1; PSMA6; KIAA0907; ZNF385D; MRPL23
    SUMO binding RPS3; USPL1; HERC2; USP25; PML; TOLLIP; TDG; CBX4
    damaged DNA binding TRP53; RAD1; APTX; POLI; CRY-DASH; DCLRE1A; POLK; GTF2H3; TRPC2; TRP63
    endodeoxyribonuclease activity ZRANB3; MBD4; DNASE1L1; ERCC4; DNASE1L3; ERCC5; DNASE1; MRE11A; DNASE1L2; APLF
    enzyme binding ECM1; ATP6AP2; POLB; UGT1A7; DDX5; ITGB3; Txn1; NOTCH1; PUS7; UGT1A6A
    iron-sulfur cluster binding ISCUB; PRIM2; AOX3; FDX1B; GLRX3; EXO5; AOX3L1; RSAD1; FXN; ELP3
    kinase binding PPP2R5A; DUSP12; TRIP6; DLG4; FAS; PFKL; PER3; UBQLN1; ATF5; C2orf44
    mRNA binding DCP1B; ZFP36; NANOS2; SRSF1; DXO; RBM25; IGF2BP1; KIAA0020; RPS26; CELF4
    microtubule binding NDEL1; PRNP; CRYAB; KATNA1; CHP; SGIP1; RCC2; NEIL2; PLK1; KATNAL2
    oxidized purine DNA binding OGG1; RPS3
    oxidized purine nucleobase lesion DNA N-glycosylase activity OGG1; RPS3
    oxidized pyrimidine DNA binding RPS3
    poly(A) RNA binding SMC1A; LIN28B; CCT6A; STRAP; NOP16; EIF1AX; RAVER1; C11orf68; EIF4G2; SRSF9
    protein binding TMEM30A; BANP; GIMAP5; FOXM1; SMARCD1; UNG; FAM122A; ZG16; ALG2; HSPA14
    protein kinase A binding AKAP13; AKAP12; NBEA; Akap2; RPS3; LRRK2; DACT1; Akap3; AKAP6; MYRIP
    protein kinase binding MSH2; ADIPOR1; MAPKAP1; TUBB3; BCL10; CRY1; TENC1; CAMK2N1; TELO2; ELP2
    small ribosomal subunit rRNA binding MRPS11; CIRBP; UTP23; NSUN4; MRPS6; RPS3; RPS14; RPS13
    structural constituent of ribosome SLC25A47A; RPL5A; NDUFA7; RPS17; MRPS9; MRPL4; RSL24D1; RPL27A; RPL35; RPL30
    supercoiled DNA binding PSIP1; RPS3; HMGB2; HMGB1
    transcription factor binding PPP1R13L; MED25; C1QBP; GATA3; MED12; PDX1; UBN1; TNFRSF10A; GTF2A1; TMEM173
    tubulin binding STMN4; EML2; STMN1B; TPPP; KIF14; STMN4L; CLIP1; RPS3; AGBL5; TPPP3
    ubiquitin-like protein conjugating enzyme binding RPS3; PARK7; RNF185

    RPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS3.

    RELA; MDM2; NFKBIA

    Ahn, EH; Kim, DW; et al. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. FREE RADICAL BIOLOGY AND MEDICINE 55:36-45(2013).
    Choi, SH; Kim, SY; et al. Immunohistochemical studies of human ribosomal protein s3 (rpS3). JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 39:208-215(2006).
    HANDA, H; GUALBERTO, JM; et al. CHARACTERIZATION OF THE MITOCHONDRIAL ORFB GENE AND ITS DERIVATIVE, ORF224, A CHIMERIC OPEN READING FRAME SPECIFIC TO ONE MITOCHONDRIAL GENOME OF THE POLIMA MALE-STERILE CYTOPLASM IN RAPESEED (BRASSICA-NAPUS L). CURRENT GENETICS 28:546-552(1995).

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