RPS3

  • Official Full Name

    ribosomal protein S3

  • Overview

    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • Synonyms

    RPS3; ribosomal protein S3; S3; 40S ribosomal protein S3; IMR-90 ribosomal protein S3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Fruit Fly
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS3-29970TH Recombinant Human RPS3 E.coli N/A 243 amino acids
Human RPS3-2420H Recombinant Human Ribosomal Protein S3 E.coli N/A
Human RPS3-2421H Recombinant Human Ribosomal Protein S3, His-tagged E.coli His
Human RPS3-6890H Recombinant Human Ribosomal Protein S3, His-tagged E.coli His 1-243aa
Human RPS3-480H Recombinant Human RPS3, GST-tagged E.coli GST
Human RPS3-30468TH Recombinant Human RPS3 protein, His-tagged E.coli His
Human RPS3-563HCL Recombinant Human RPS3 lysate HEK293 N/A
Human RPS3-3450H Recombinant Human RPS3 protein, His-SUMO-tagged E.coli His-SUMO 2-243aa
Human RPS3-1106H Recombinant Human RPS3 protein, His-tagged E.coli His 2-243aa
Mouse RPS3-14489M Recombinant Mouse RPS3 Protein Mammalian Cell His
Mouse RPS3-7788M Recombinant Mouse RPS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RPS3-7788M-B Recombinant Mouse RPS3 Protein Pre-coupled Magnetic Beads HEK293
Rat RPS3-5168R Recombinant Rat RPS3 Protein Mammalian Cell His
Rat RPS3-4827R Recombinant Rat RPS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RPS3-4827R-B Recombinant Rat RPS3 Protein Pre-coupled Magnetic Beads HEK293
Fruit Fly RPS3-2481F Recombinant Fruit Fly RPS3 Protein (1-246 aa), His-tagged E.coli His 1-246 aa
Rhesus Macaque RPS3-4025R Recombinant Rhesus monkey RPS3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RPS3-3842R-B Recombinant Rhesus Macaque RPS3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RPS3-3842R Recombinant Rhesus Macaque RPS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RPS3-11372Z Recombinant Zebrafish RPS3 Mammalian Cell His
Chicken RPS3-2532C Recombinant Chicken RPS3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

RPS3 involved in several pathways and played different roles in them. We selected most pathways RPS3 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RibosomeMRPL20;RPL13;RPL6;RPS3A;RSL24D1;RPL34;RPS11;RPL37A;RPL15

RPS3 has several biochemical functions, for example, NOT DNA N-glycosylase activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS3 itself. We selected most functions RPS3 had, and list some proteins which have the same functions with RPS3. You can find most of the proteins on our site.

Function Related Protein
NOT DNA N-glycosylase activity
DNA bindingRFX3;ATF4;AKAP8L;ZNF521;GSX1;SP140;NKX2.2B;NKX1.2LB;HIST1H4G
DNA-(apurinic or apyrimidinic site) lyase activityNEIL2;APEX2;HMGA1;ALKBH1;APEX1;HMGA2;NEIL1;HMGA1B;RPS3
Hsp70 protein bindingCDK1;STUB1;PARK2;ST13;RNF207;C11orf73;PPEF2;DNAJC10;PACRG
Hsp90 protein bindingGBP1;PPEF2;CHORDC1;HDAC6;NASP;STUB1;ERN1;PPID;CSNK2A1
NF-kappaB bindingHDAC3;HDAC2;HDAC1;BCL10;CDKN2A;HIF1AN;ANKRD42;COMMD6;DNAJA3
RNA bindingNSUN5B;RNASEN;RBM23;TTC6;TIMM50;HBP1;DCP2;GRB7;DHX34
SUMO bindingHERC2;RPS3;USPL1;TDG;USP25;TOLLIP;CBX4;PML
damaged DNA bindingXPA;RAD1;RAD23B;HMGB1;RBBP8;NEIL2;POLK;NEIL1;TP53BP1
endodeoxyribonuclease activityDNASE1L3;RPS3;ERCC5;APLF;DNASE1L3L;DNASE1;ERCC4;MRE11A;DNASE1L2
enzyme bindingUSP22;HSPA8;HIF1A;RPA3;NPM2;NOTCH3;ARPC4;HMGA1-RS1;SUDS3
iron-sulfur cluster bindingCMAH;AOX3L1;AOX3;AIFM4;NDUFS1;GLRX3;NUBP1;EXO5;ELP3
kinase bindingTOLLIP;JAKMIP3;BARD1;ATF5;STUB1;BCL10;DLG3;CHP1;PTPN22
mRNA bindingSOSTDC1B;LUC7L;RPL35;NUDT21;RBFOX2;LUC7L2;ESRP1;RPS2;HSP26
microtubule bindingCRIPT;KIF16B;LRPPRC;KATNB1;MAP1LC3C;GAPDH;DPYSL5B;PLK1;MARK4
oxidized purine DNA bindingOGG1;RPS3
oxidized purine nucleobase lesion DNA N-glycosylase activityRPS3;OGG1
oxidized pyrimidine DNA binding
poly(A) RNA bindingPTBP2;CSNK1E;ZRANB2;NHP2;RPL21;FAM103A1;DNTTIP2;MRPL32;STXBP1
protein bindingSF3B4;UBE3A;HAND1;BACE1;C4orf26;MAGEA11;POU5F1;NCAPH;VPS28
protein kinase A bindingLRRK2;AKAP4;DACT1;AKAP12;AKAP17A;Akap3;AKAP6;AKAP12B;DACT2
protein kinase bindingCYLD;SV2A;FBXO5;CCNE1;GSTP2;TRIM22;GATA6;GRB7;Cd24a
small ribosomal subunit rRNA bindingMRPS11;UTP23;NSUN4;RPS3;MRPS6;CIRBP;RPS14;RPS13
structural constituent of ribosomeMRPL15;RPS4Y2;RPS9;RPS5;RPS4Y1;MRPS2;MRPS23;MRPS18B;MRPL52
supercoiled DNA bindingPSIP1;HMGB1;HMGB2;RPS3
transcription factor bindingDOT1L;NKX2-5;HES2;ATG7;HDAC1;BCOR;ZBTB49;TCF12;UBE2I
tubulin bindingRABGAP1;NCALD;CENPJ;AGBL5;ALDOA;AGBL1;IFT81;PRNP;KIF14
ubiquitin-like protein conjugating enzyme bindingPARK7;RPS3;RNF185

RPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS3.

RELA; MDM2; NFKBIA

Research Area

Related articles

Ahn, EH; Kim, DW; et al. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. FREE RADICAL BIOLOGY AND MEDICINE 55:36-45(2013).
Choi, SH; Kim, SY; et al. Immunohistochemical studies of human ribosomal protein s3 (rpS3). JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 39:208-215(2006).
HANDA, H; GUALBERTO, JM; et al. CHARACTERIZATION OF THE MITOCHONDRIAL ORFB GENE AND ITS DERIVATIVE, ORF224, A CHIMERIC OPEN READING FRAME SPECIFIC TO ONE MITOCHONDRIAL GENOME OF THE POLIMA MALE-STERILE CYTOPLASM IN RAPESEED (BRASSICA-NAPUS L). CURRENT GENETICS 28:546-552(1995).
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