RPS3 Protein

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RPS3

Official Full Name	ribosomal protein S3
Background	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Synonyms	RPS3; ribosomal protein S3; S3; 40S ribosomal protein S3; IMR-90 ribosomal protein S3;

Type:
Recombinant Proteins

Species :
Chicken
Fruit Fly
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source :
E.coli
HEK293
Mammalian Cell

Tag :
GST
His
His (Fc)-Avi
His-SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	RPS3-2420H	Recombinant Human Ribosomal Protein S3	E.coli	N/A	Inquiry
Human	RPS3-2421H	Recombinant Human Ribosomal Protein S3, His-tagged	E.coli	His	Inquiry
Human	RPS3-29970TH	Recombinant Human RPS3	E.coli	N/A	Inquiry
Human	RPS3-30468TH	Recombinant Human RPS3 protein, His-tagged	E.coli	His	Inquiry
Human	RPS3-480H	Recombinant Human RPS3, GST-tagged	E.coli	GST	Inquiry
Human	RPS3-6890H	Recombinant Human Ribosomal Protein S3, His-tagged	E.coli	His	Inquiry
Mouse	RPS3-14489M	Recombinant Mouse RPS3 Protein	Mammalian Cell	His	Inquiry
Rat	RPS3-5168R	Recombinant Rat RPS3 Protein	Mammalian Cell	His	Inquiry
Rhesus Macaque	RPS3-4025R	Recombinant Rhesus monkey RPS3 Protein, His-tagged	Mammalian Cell	His	Inquiry
Chicken	RPS3-2532C	Recombinant Chicken RPS3	Mammalian Cell	His	Inquiry
Zebrafish	RPS3-11372Z	Recombinant Zebrafish RPS3	Mammalian Cell	His	Inquiry
Human	RPS3-563HCL	Recombinant Human RPS3 lysate	HEK293	N/A	Inquiry
Human	RPS3-1106H	Recombinant Human RPS3 protein, His-tagged	E.coli	His	Inquiry
Human	RPS3-3450H	Recombinant Human RPS3 protein, His-SUMO-tagged	E.coli	His-SUMO	Inquiry
Rhesus Macaque	RPS3-3842R	Recombinant Rhesus Macaque RPS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	RPS3-4827R	Recombinant Rat RPS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	RPS3-7788M	Recombinant Mouse RPS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Fruit Fly	RPS3-2481F	Recombinant Fruit Fly RPS3 Protein (1-246 aa), His-tagged	E.coli	His	Inquiry

Involved Pathway Protein Function Interacting Protein RPS3 Related Articles

RPS3 involved in several pathways and played different roles in them. We selected most pathways RPS3 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome	UBA52; MRPS7; RPS2; RPL38; RPL36; RPL8; RPS27L; RPL29; MRPL33; RPS27

RPS3 has several biochemical functions, for example, NOT DNA N-glycosylase activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS3 itself. We selected most functions RPS3 had, and list some proteins which have the same functions with RPS3. You can find most of the proteins on our site.

Function	Related Protein
NOT DNA N-glycosylase activity	RPS3
DNA binding	H1M; MCM6L; TOP3B; HIST1H4A; HOMEZB; ZNF738; MCM3L; MYCS; ZNF565; SPRTN
DNA-(apurinic or apyrimidinic site) lyase activity	HMGA1B; NTHL1; APLF; RPS3; ALKBH1; APEX1; HMGA2; HMGA1A; NEIL1; APEX2
Hsp70 protein binding	DNAJA1; ERN1; STIP1; METTL21A; L7RN6; RPS3; PPEF2; DNAJC2; PACRG; C11orf73
Hsp90 protein binding	PPEF2; USP19; PACRG; HIF1A; FKBP6; AHR; NASP; ARNTL; CDC37; CSNK2A1
NF-kappaB binding	PSMA6; NFKBIA; FOXP3; RPS3; DNAJA3; ANXA4; BCL10; AP1S2; HDAC2; HDAC1
RNA binding	NANOS3; ENDOU2; SNRPA; HNRNPH3; KIAA0430; JAKMIP1; PSMA6; KIAA0907; ZNF385D; MRPL23
SUMO binding	RPS3; USPL1; HERC2; USP25; PML; TOLLIP; TDG; CBX4
damaged DNA binding	TRP53; RAD1; APTX; POLI; CRY-DASH; DCLRE1A; POLK; GTF2H3; TRPC2; TRP63
endodeoxyribonuclease activity	ZRANB3; MBD4; DNASE1L1; ERCC4; DNASE1L3; ERCC5; DNASE1; MRE11A; DNASE1L2; APLF
enzyme binding	ECM1; ATP6AP2; POLB; UGT1A7; DDX5; ITGB3; Txn1; NOTCH1; PUS7; UGT1A6A
iron-sulfur cluster binding	ISCUB; PRIM2; AOX3; FDX1B; GLRX3; EXO5; AOX3L1; RSAD1; FXN; ELP3
kinase binding	PPP2R5A; DUSP12; TRIP6; DLG4; FAS; PFKL; PER3; UBQLN1; ATF5; C2orf44
mRNA binding	DCP1B; ZFP36; NANOS2; SRSF1; DXO; RBM25; IGF2BP1; KIAA0020; RPS26; CELF4
microtubule binding	NDEL1; PRNP; CRYAB; KATNA1; CHP; SGIP1; RCC2; NEIL2; PLK1; KATNAL2
oxidized purine DNA binding	OGG1; RPS3
oxidized purine nucleobase lesion DNA N-glycosylase activity	OGG1; RPS3
oxidized pyrimidine DNA binding	RPS3
poly(A) RNA binding	SMC1A; LIN28B; CCT6A; STRAP; NOP16; EIF1AX; RAVER1; C11orf68; EIF4G2; SRSF9
protein binding	TMEM30A; BANP; GIMAP5; FOXM1; SMARCD1; UNG; FAM122A; ZG16; ALG2; HSPA14
protein kinase A binding	AKAP13; AKAP12; NBEA; Akap2; RPS3; LRRK2; DACT1; Akap3; AKAP6; MYRIP
protein kinase binding	MSH2; ADIPOR1; MAPKAP1; TUBB3; BCL10; CRY1; TENC1; CAMK2N1; TELO2; ELP2
small ribosomal subunit rRNA binding	MRPS11; CIRBP; UTP23; NSUN4; MRPS6; RPS3; RPS14; RPS13
structural constituent of ribosome	SLC25A47A; RPL5A; NDUFA7; RPS17; MRPS9; MRPL4; RSL24D1; RPL27A; RPL35; RPL30
supercoiled DNA binding	PSIP1; RPS3; HMGB2; HMGB1
transcription factor binding	PPP1R13L; MED25; C1QBP; GATA3; MED12; PDX1; UBN1; TNFRSF10A; GTF2A1; TMEM173
tubulin binding	STMN4; EML2; STMN1B; TPPP; KIF14; STMN4L; CLIP1; RPS3; AGBL5; TPPP3
ubiquitin-like protein conjugating enzyme binding	RPS3; PARK7; RNF185

RPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS3.

RELA; MDM2; NFKBIA

Ahn, EH; Kim, DW; et al. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. FREE RADICAL BIOLOGY AND MEDICINE 55:36-45(2013).

Choi, SH; Kim, SY; et al. Immunohistochemical studies of human ribosomal protein s3 (rpS3). JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 39:208-215(2006).

HANDA, H; GUALBERTO, JM; et al. CHARACTERIZATION OF THE MITOCHONDRIAL ORFB GENE AND ITS DERIVATIVE, ORF224, A CHIMERIC OPEN READING FRAME SPECIFIC TO ONE MITOCHONDRIAL GENOME OF THE POLIMA MALE-STERILE CYTOPLASM IN RAPESEED (BRASSICA-NAPUS L). CURRENT GENETICS 28:546-552(1995).

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