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RPS6

  • Official Full Name

    ribosomal protein S6

  • Overview

    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
  • Synonyms

    RPS6; ribosomal protein S6; S6; 40S ribosomal protein S6; phosphoprotein NP33;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6-30769TH Recombinant Human RPS6 E.coli N/A
Human RPS6-307H Recombinant Human RPS6, GST-tagged Wheat Germ GST
Human RPS6-567HCL Recombinant Human RPS6 lysate HEK293 N/A
Human RPS6-445HF Recombinant Full Length Human RPS6 Protein, GST-tagged In Vitro Cell Free System GST 249 amino acids
Human RPS6-1102H Recombinant Human RPS6 protein, His-GST-tagged E.coli His/GST 35-229aa
Mouse RPS6-14492M Recombinant Mouse RPS6 Protein Mammalian Cell His
Mouse RPS6-7791M Recombinant Mouse RPS6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RPS6-7791M-B Recombinant Mouse RPS6 Protein Pre-coupled Magnetic Beads HEK293
Rat RPS6-5171R Recombinant Rat RPS6 Protein Mammalian Cell His
Rat RPS6-4830R Recombinant Rat RPS6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RPS6-4830R-B Recombinant Rat RPS6 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RPS6-1072Z Recombinant Zebrafish RPS6 Mammalian Cell His
Chicken RPS6-6778C Recombinant Chicken RPS6 Mammalian Cell His
RPS6-171 Recombinant RPS6 Protein, GST-tagged Insect Cell GST
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • RPS6 Related Signal Pathway

RPS6 involved in several pathways and played different roles in them. We selected most pathways RPS6 participated on our site, such as Ribosome, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RibosomeRPL18A;RPS26;MRPL13;RPS14;RPL26;RPS27.2;MRPL32;RPL39;RPL10A
HIF- signaling pathwayEPO;CAMK2A;HK3;PIK3CD;LTBR;PRKCG;INSR;VHL;ENO3
mTOR signaling pathwayRICTOR;IGF1;TSC2;MLST8;RPS6KB1;PIK3R3A;RRN3;ULK1;PTENA
PIK-Akt signaling pathwayITGB4;GHR;CRTC2;TSC1;HRAS;MAPK3;IFNA12;CREB3L2;HSP90B1
Insulin signaling pathwayRAPGEF1B;TSC1;FLOT2A;G6PC2;PYGB;SOCS1;FLOT1B;PIK3R3B;PRKAR1A
Proteoglycans in cancerPLCG1;ARHGEF1;HSPG2;MSN;CD44;PIK3R3;RAF1;ARHGEF12;FGFR1

RPS6 has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6 itself. We selected most functions RPS6 had, and list some proteins which have the same functions with RPS6. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingLRPPRC;METAP2;SNRNP40;HNRNPF;RPGR;HIST1H1E;EIF2C3;RPL13A;DDX41
protein bindingNMUR2;WWTR1;STAG3;PCDH18B;Aatk;GCM1;C9orf43;DUSP26;CSNK2B
protein kinase bindingPPP1R12A;FBXO7;CADPS;STK11IP;EMP2;CCNT2A;CHRNA7;MEF2A;RPS6KA3
structural constituent of ribosomeRPL36AL;MRPS15;RPL31;RPS27.2;MRPL52;RPL12;RPS5;RPS26;SLC25A38A

RPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6.

STAU1; NCBP1; PASK; ESR1; PPP2R2B; AURKA; ATF4; RPS6KA2; RPS6KA1; RPS6KB2; MAP3K1

Research Area

Related articles

Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
von der Heyde, S; Bender, C; et al. Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC SYSTEMS BIOLOGY 8:-(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How about the localization and role of RPS6 in cells? 02/08/2022

RPS6 is mainly located on ribosomes in the cytoplasm and is involved in the regulation of protein translation. It is able to bind to and respond to the 5' cap structure on mRNA, regulating the initiation and efficiency of translation. In addition, RPS6 is also involved in the regulation of cell signal transduction and gene expression.

What are the limitations of the studies on RPS6? 02/05/2022

There are still some limitations in the current research on RPS6, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since RPS6 is an important component in the cytoplasm, its regulation may also have some side effects.

What diseases may be caused by mutations or variants in RPS6? 10/06/2021

Mutations or variants in RPS6 may lead to some genetic diseases such as Charcot-Marie-Tooth disease (CMT) and peripheral neuropathy. These disorders usually manifest as damage and dysfunction of peripheral nerves.

Are there novel RPS6 mechanisms or functions in recent studies? 05/04/2021

Recent studies have found that RPS6 is also involved in processes such as autophagy and apoptosis. These processes have an important impact on cell survival and death, and also provide new ideas for the treatment of some diseases related to RPS6.

Is there a relationship between RPS6 expression levels and disease? 12/17/2020

Some studies have shown that RPS6 expression levels are associated with a variety of diseases. For example, in some cancers, RPS6 expression levels are upregulated, which promotes the growth and proliferation of tumor cells. In neurodegenerative diseases, RPS6 expression levels may be down-regulated, leading to cell death.

How is RPS6 expression regulated? 09/18/2020

The expression of RPS6 is regulated by a variety of factors, including upstream transcription factors, signal transduction pathways, and environmental factors. For example, the mTORC1 signaling pathway can regulate the expression level of RPS6, while nutrients, hormones, and growth factors can also affect the expression of RPS6.

Customer Reviews (3)

Write a review
Reviews
11/11/2022

    The reproducibility is good, and the results of multiple experiments are consistent.

    04/16/2022

      The expression level is high, the stability is good, and it is suitable for experiments with high precision requirements.

      06/14/2021

        They have a wide range of products and can always find the recombinant protein we need.

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