RPS6 Protein


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Official Full Name ribosomal protein S6
Background Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Synonyms RPS6; ribosomal protein S6; S6; 40S ribosomal protein S6; phosphoprotein NP33;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • His/GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RPS6-30769TH Recombinant Human RPS6 E.coli N/A Inquiry
    Human RPS6-307H Recombinant Human RPS6, GST-tagged Wheat Germ GST Inquiry
    Mouse RPS6-14492M Recombinant Mouse RPS6 Protein Mammalian Cell His Inquiry
    Rat RPS6-5171R Recombinant Rat RPS6 Protein Mammalian Cell His Inquiry
    Chicken RPS6-6778C Recombinant Chicken RPS6 Mammalian Cell His Inquiry
    Zebrafish RPS6-1072Z Recombinant Zebrafish RPS6 Mammalian Cell His Inquiry
    Human RPS6-567HCL Recombinant Human RPS6 lysate HEK293 N/A Inquiry
    Human RPS6-1102H Recombinant Human RPS6 protein, His-GST-tagged E.coli His/GST Inquiry
    Human RPS6-445HF Recombinant Full Length Human RPS6 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Rat RPS6-4830R Recombinant Rat RPS6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Mouse RPS6-7791M Recombinant Mouse RPS6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    RPS6-171 Recombinant RPS6 Protein, GST-tagged Insect Cell GST Inquiry

    RPS6 involved in several pathways and played different roles in them. We selected most pathways RPS6 participated on our site, such as Ribosome, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome RPS2; RPL36A; RPL27; RPS6; MRPL30; RPS26; RPS3; MRPS2; RPL37; RPS27L
    HIF- signaling pathway GM5506; ANGPT1; INSR; EGLN1; EIF4E2; CAMK2D; TLR4; EP300; IFNGR2; AKT2
    mTOR signaling pathway DDIT4; ULK3; PIK3R3A; STK11; RRAGCB; CAB39; MAPK1; MLST8; EIF4E2RS1; PRKCG
    PIK-Akt signaling pathway GHR; MDM2; PKN3; RPTOR; Il6ra; PDGFB; Ifna11; THBS4; KLK1B4; FIGF
    Insulin signaling pathway LIPE; FBP1B; PRKAG3B; PYGM; SHC2; FBP1; FASN; PRKACG; G6PC3; TSC1B
    Proteoglycans in cancer PRKACA; PIK3CD; CBLB; PIK3CG; FZD6; ARHGEF12; RRAS2; VTN; WNT9B; MDM2

    RPS6 has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6 itself. We selected most functions RPS6 had, and list some proteins which have the same functions with RPS6. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding UPF1; ZFML; CSTF1; NOLC1; MRPS26; MKI67; CDK11B; TPR; STXBP1; RPS27.1
    protein binding ATP7B; CBLN3; ITGB4; BACE1; TSPYL4; NEFL; TSPAN4; ROCK2A; ANKRD17; VPS28
    protein kinase binding SPAG16; CNPPD1; SHC3; CRY1; B4GALT1; PPME1; MAP2K6; PDGFRB; TRIM5; PRC1
    structural constituent of ribosome MRPS36; RPL37A; RPSA; RPL27; MRPS33; RPS4Y2; MRPS14; MRPL18; RPL34; RPL39L

    RPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6.


    Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
    von der Heyde, S; Bender, C; et al. Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC SYSTEMS BIOLOGY 8:-(2014).

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