RPS6 involved in several pathways and played different roles in them. We selected most pathways RPS6 participated on our site, such as Ribosome, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Ribosome |
RPS2; RPL36A; RPL27; RPS6; MRPL30; RPS26; RPS3; MRPS2; RPL37; RPS27L |
| HIF- signaling pathway |
GM5506; ANGPT1; INSR; EGLN1; EIF4E2; CAMK2D; TLR4; EP300; IFNGR2; AKT2 |
| mTOR signaling pathway |
DDIT4; ULK3; PIK3R3A; STK11; RRAGCB; CAB39; MAPK1; MLST8; EIF4E2RS1; PRKCG |
| PIK-Akt signaling pathway |
GHR; MDM2; PKN3; RPTOR; Il6ra; PDGFB; Ifna11; THBS4; KLK1B4; FIGF |
| Insulin signaling pathway |
LIPE; FBP1B; PRKAG3B; PYGM; SHC2; FBP1; FASN; PRKACG; G6PC3; TSC1B |
| Proteoglycans in cancer |
PRKACA; PIK3CD; CBLB; PIK3CG; FZD6; ARHGEF12; RRAS2; VTN; WNT9B; MDM2 |
RPS6 has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6 itself. We selected most functions RPS6 had, and list some proteins which have the same functions with RPS6. You can find most of the proteins on our site.
| Function |
Related Protein |
| poly(A) RNA binding |
UPF1; ZFML; CSTF1; NOLC1; MRPS26; MKI67; CDK11B; TPR; STXBP1; RPS27.1 |
| protein binding |
ATP7B; CBLN3; ITGB4; BACE1; TSPYL4; NEFL; TSPAN4; ROCK2A; ANKRD17; VPS28 |
| protein kinase binding |
SPAG16; CNPPD1; SHC3; CRY1; B4GALT1; PPME1; MAP2K6; PDGFRB; TRIM5; PRC1 |
| structural constituent of ribosome |
MRPS36; RPL37A; RPSA; RPL27; MRPS33; RPS4Y2; MRPS14; MRPL18; RPL34; RPL39L |
RPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6.
STAU1; NCBP1; PASK; ESR1; PPP2R2B; AURKA; ATF4; RPS6KA2; RPS6KA1; RPS6KB2; MAP3K1
Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
von der Heyde, S; Bender, C; et al. Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC SYSTEMS BIOLOGY 8:-(2014).
