RPS6
-
Official Full Name
ribosomal protein S6
-
Overview
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] -
Synonyms
RPS6; ribosomal protein S6; S6; 40S ribosomal protein S6; phosphoprotein NP33;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | RPS6-30769TH | Recombinant Human RPS6 | E.coli | N/A |
|
|
| Human | RPS6-307H | Recombinant Human RPS6, GST-tagged | Wheat Germ | GST | ||
| Human | RPS6-567HCL | Recombinant Human RPS6 lysate | HEK293 | N/A |
|
|
| Human | RPS6-445HF | Recombinant Full Length Human RPS6 Protein, GST-tagged | In Vitro Cell Free System | GST | 249 amino acids |
|
| Human | RPS6-1102H | Recombinant Human RPS6 protein, His-GST-tagged | E.coli | His/GST | 35-229aa |
|
| Mouse | RPS6-14492M | Recombinant Mouse RPS6 Protein | Mammalian Cell | His |
|
|
| Mouse | RPS6-7791M | Recombinant Mouse RPS6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Mouse | RPS6-7791M-B | Recombinant Mouse RPS6 Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Rat | RPS6-5171R | Recombinant Rat RPS6 Protein | Mammalian Cell | His |
|
|
| Rat | RPS6-4830R | Recombinant Rat RPS6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Rat | RPS6-4830R-B | Recombinant Rat RPS6 Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Zebrafish | RPS6-1072Z | Recombinant Zebrafish RPS6 | Mammalian Cell | His |
|
|
| Chicken | RPS6-6778C | Recombinant Chicken RPS6 | Mammalian Cell | His |
|
|
| RPS6-171 | Recombinant RPS6 Protein, GST-tagged | Insect Cell | GST |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- RPS6 Related Articles
- RPS6 Related Research Area
- RPS6 Related Signal Pathway
RPS6 involved in several pathways and played different roles in them. We selected most pathways RPS6 participated on our site, such as Ribosome, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL15;MRPL4;RPL29;MRPS5;MRPS10;RPS23;MRPS21;MRPL34;RPS27.1 |
| HIF- signaling pathway | MAPK3;RPS6;PIK3CD;PDK1;TFRC;CUL2;EIF4E1B;BCL2;INS2 |
| mTOR signaling pathway | INS1;DEPDC6;RPTOR;RPS6KA3;TNF;PIK3R1;EIF4E2;CAB39;RRAGCA |
| PIK-Akt signaling pathway | PPP2R5A;EIF4E1B;Ifna11;IL3RA;LAMB4;COL6A4;ITGB4;THBS2;TCL1B4 |
| Insulin signaling pathway | TSC1;IRS4;CALM2;PIK3R5;GYS2;PCK1;PPP1CC;PIK3R2;PPP1CA |
| Proteoglycans in cancer | PDPK1;WNT8A;SDC2;PIK3R1;WNT7B;FASLG;PLCG2;KRAS;HPSE |
RPS6 has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6 itself. We selected most functions RPS6 had, and list some proteins which have the same functions with RPS6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | NUSAP1;RBM5;TRA2A;RPSA;UBA1;RPS2;MRPL20;ERI3;DEK |
| protein binding | Chrng;HIST1H4L;KISS1R;PPP1R7;FAM176B;EEF1G;FAM114A1;RUVBL2;KEAP1 |
| protein kinase binding | CNPPD1;CRY1;GATA6;SNAP91;CAV2;RPS19;PRKCZ;SYN1;MAPK4 |
| structural constituent of ribosome | MRPS24;MRPL49;MRPL16;RPS24;MRPS34;SLC25A47A;MRPS18C;MRPS22;RPLP2L |
RPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6.
STAU1; NCBP1; PASK; ESR1; PPP2R2B; AURKA; ATF4; RPS6KA2; RPS6KA1; RPS6KB2; MAP3K1
- Q&As
- Reviews
Q&As (6)
Ask a questionRPS6 is mainly located on ribosomes in the cytoplasm and is involved in the regulation of protein translation. It is able to bind to and respond to the 5' cap structure on mRNA, regulating the initiation and efficiency of translation. In addition, RPS6 is also involved in the regulation of cell signal transduction and gene expression.
There are still some limitations in the current research on RPS6, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since RPS6 is an important component in the cytoplasm, its regulation may also have some side effects.
Mutations or variants in RPS6 may lead to some genetic diseases such as Charcot-Marie-Tooth disease (CMT) and peripheral neuropathy. These disorders usually manifest as damage and dysfunction of peripheral nerves.
Recent studies have found that RPS6 is also involved in processes such as autophagy and apoptosis. These processes have an important impact on cell survival and death, and also provide new ideas for the treatment of some diseases related to RPS6.
Some studies have shown that RPS6 expression levels are associated with a variety of diseases. For example, in some cancers, RPS6 expression levels are upregulated, which promotes the growth and proliferation of tumor cells. In neurodegenerative diseases, RPS6 expression levels may be down-regulated, leading to cell death.
The expression of RPS6 is regulated by a variety of factors, including upstream transcription factors, signal transduction pathways, and environmental factors. For example, the mTORC1 signaling pathway can regulate the expression level of RPS6, while nutrients, hormones, and growth factors can also affect the expression of RPS6.
Customer Reviews (3)
Write a reviewThe reproducibility is good, and the results of multiple experiments are consistent.
The expression level is high, the stability is good, and it is suitable for experiments with high precision requirements.
They have a wide range of products and can always find the recombinant protein we need.
Ask a Question for All RPS6 Products
Required fields are marked with *
My Review for All RPS6 Products
Required fields are marked with *
