|Official Full Name||ribosomal protein S6|
|Background||Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]|
|Synonyms||RPS6; ribosomal protein S6; S6; 40S ribosomal protein S6; phosphoprotein NP33;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RPS6 involved in several pathways and played different roles in them. We selected most pathways RPS6 participated on our site, such as Ribosome, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ribosome||RPS2; RPL36A; RPL27; RPS6; MRPL30; RPS26; RPS3; MRPS2; RPL37; RPS27L|
|HIF- signaling pathway||GM5506; ANGPT1; INSR; EGLN1; EIF4E2; CAMK2D; TLR4; EP300; IFNGR2; AKT2|
|mTOR signaling pathway||DDIT4; ULK3; PIK3R3A; STK11; RRAGCB; CAB39; MAPK1; MLST8; EIF4E2RS1; PRKCG|
|PIK-Akt signaling pathway||GHR; MDM2; PKN3; RPTOR; Il6ra; PDGFB; Ifna11; THBS4; KLK1B4; FIGF|
|Insulin signaling pathway||LIPE; FBP1B; PRKAG3B; PYGM; SHC2; FBP1; FASN; PRKACG; G6PC3; TSC1B|
|Proteoglycans in cancer||PRKACA; PIK3CD; CBLB; PIK3CG; FZD6; ARHGEF12; RRAS2; VTN; WNT9B; MDM2|
RPS6 has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6 itself. We selected most functions RPS6 had, and list some proteins which have the same functions with RPS6. You can find most of the proteins on our site.
|poly(A) RNA binding||UPF1; ZFML; CSTF1; NOLC1; MRPS26; MKI67; CDK11B; TPR; STXBP1; RPS27.1|
|protein binding||ATP7B; CBLN3; ITGB4; BACE1; TSPYL4; NEFL; TSPAN4; ROCK2A; ANKRD17; VPS28|
|protein kinase binding||SPAG16; CNPPD1; SHC3; CRY1; B4GALT1; PPME1; MAP2K6; PDGFRB; TRIM5; PRC1|
|structural constituent of ribosome||MRPS36; RPL37A; RPSA; RPL27; MRPS33; RPS4Y2; MRPS14; MRPL18; RPL34; RPL39L|
RPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6.
STAU1; NCBP1; PASK; ESR1; PPP2R2B; AURKA; ATF4; RPS6KA2; RPS6KA1; RPS6KB2; MAP3K1
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