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Recombinant Human RPS6, GST-tagged

Cat.No. : RPS6-307H
Product Overview : Recombinant Human RPS6(1 a.a. - 249 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
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Description : Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 53.13 kDa
AA Sequence : MKLNISFPATGCQKLIEVDDERKLR TFYEKRMATEVAADALGEEWKGYVV RISGGNDKQGFPMKQGVLTHGRVRL LLSKGHSCYRPRRTGERKRKSVRGC IVDANLSVLNLVIVKKGEKDIPGLT DTTVPRRLGPKRASRIRKLFNLSKE DDVRQYVVRKPLNKEGKKPRTKAPK IQRLVTPRVLQHKRRRIALKKQRTK KNKEEAAEYAKLLAKRMKEAKEKRQ EQIAKRRRLSSLRASTSKSESSQK
Applications : ELISA; WB-Re; AP; Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : RPS6 ribosomal protein S6 [ Homo sapiens ]
Official Symbol : RPS6
Synonyms : RPS6; ribosomal protein S6; 40S ribosomal protein S6; phosphoprotein NP33; S6
Gene ID : 6194
mRNA Refseq : NM_001010
Protein Refseq : NP_001001
MIM : 180460
UniProt ID : P62753
Chromosome Location : 9p21
Pathway : Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S; B Cell Receptor Signaling Pathway; Cap-dependent Translation Initiation
Function : protein binding; structural constituent of ribosome; protein kinase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How about the localization and role of RPS6 in cells? 02/08/2022

RPS6 is mainly located on ribosomes in the cytoplasm and is involved in the regulation of protein translation. It is able to bind to and respond to the 5' cap structure on mRNA, regulating the initiation and efficiency of translation. In addition, RPS6 is also involved in the regulation of cell signal transduction and gene expression.

What are the limitations of the studies on RPS6? 02/05/2022

There are still some limitations in the current research on RPS6, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since RPS6 is an important component in the cytoplasm, its regulation may also have some side effects.

What diseases may be caused by mutations or variants in RPS6? 10/06/2021

Mutations or variants in RPS6 may lead to some genetic diseases such as Charcot-Marie-Tooth disease (CMT) and peripheral neuropathy. These disorders usually manifest as damage and dysfunction of peripheral nerves.

Are there novel RPS6 mechanisms or functions in recent studies? 05/04/2021

Recent studies have found that RPS6 is also involved in processes such as autophagy and apoptosis. These processes have an important impact on cell survival and death, and also provide new ideas for the treatment of some diseases related to RPS6.

Is there a relationship between RPS6 expression levels and disease? 12/17/2020

Some studies have shown that RPS6 expression levels are associated with a variety of diseases. For example, in some cancers, RPS6 expression levels are upregulated, which promotes the growth and proliferation of tumor cells. In neurodegenerative diseases, RPS6 expression levels may be down-regulated, leading to cell death.

How is RPS6 expression regulated? 09/18/2020

The expression of RPS6 is regulated by a variety of factors, including upstream transcription factors, signal transduction pathways, and environmental factors. For example, the mTORC1 signaling pathway can regulate the expression level of RPS6, while nutrients, hormones, and growth factors can also affect the expression of RPS6.

Customer Reviews (3)

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11/11/2022

    The reproducibility is good, and the results of multiple experiments are consistent.

    04/16/2022

      The expression level is high, the stability is good, and it is suitable for experiments with high precision requirements.

      06/14/2021

        They have a wide range of products and can always find the recombinant protein we need.

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