RTKN
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Official Full Name
rhotekin
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Overview
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
RTKN; rhotekin; B5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- RTKN Related Articles
RTKN involved in several pathways and played different roles in them. We selected most pathways RTKN participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, G13 Signaling Pathway, RHO GTPase Effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with RTKN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Alpha6-Beta4 Integrin Signaling Pathway | YWHAQ;CD151;SMAD3B;RTKN;EGFR;DST;NTN1A;DSP;EIF4EB |
G13 Signaling Pathway | RHPN2;GNA13;MYL1;MYBPH;RTKN;CIT;SH3RF1;CFL2;TNK2 |
RHO GTPase Effectors | NDEL1B;RTKN;AHCTF1;NF2A;CDCA8;BAIAP2;PRC1B;SGOL2;NOXO1 |
RHO GTPases Activate Rhotekin and Rhophilins | RHPN2;RHPN1;ROPN1;RTKN;RHOC;TAX1BP3;LIN7B |
Signal Transduction | OXGR1A.2;PCSK5;FABP11A;HEBP1;RHOT1A;GPR132B;ARHGAP24;GDI2;ARHGAP10 |
Signaling by Rho GTPases | OPHN1;KTN1;IQGAP3;FGD4;PRC1B;DCLRE1B;FAM13B;ARHGAP17B;ARHGAP20 |
RTKN has several biochemical functions, for example, GTP binding, GTP-Rho binding, GTPase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RTKN itself. We selected most functions RTKN had, and list some proteins which have the same functions with RTKN. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
GTP binding | RHOGD;RHOGC;RABL2;RP2;OPA1;RAB34A;NKIRAS1;TRIM23;RAB1BB |
GTP-Rho binding | CDC42EP1B;ROCK2A;WHAMM;CDC42EP5;CDC42EP4A;TNFAIP1;EXOC1;PKN1;CDC42EP2 |
GTPase inhibitor activity | CDC42SE1;CPEB2;RTKN;RHOH;TNK2;PDE6D;ARL2;GPS2;SLIT2 |
protein binding | RBM5;NDUFB9;OSTB;PPP3R1;CPEB4;NPBWR2;CAMSAP1L1;RNF14;MRAP |
RTKN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RTKN here. Most of them are supplied by our site. Hope this information will be useful for your research of RTKN.
RHOA; Rhoa; SORBS3; SORBS3; sseJ; gtp; Rhoa; RAC1; q8jhe2_xenla; YWHAB
- Q&As
- Reviews
Q&As (5)
Ask a questionSome studies propose RTKN as a potential therapeutic target for cancer, as inhibiting its activity may impede tumor progression.
RTKN is known to modulate signaling pathways, including those associated with cell survival, proliferation, and differentiation.
Some studies suggest that RTKN may be associated with neurodegenerative disorders, possibly influencing neuronal function.
Genetic variations in the RTKN gene have been investigated for potential links to certain diseases, but more research is needed to establish clear associations.
The potential for developing drugs targeting RTKN is being explored, with a focus on its role in diseases such as cancer.
Customer Reviews (3)
Write a reviewThey can offer specialized formulations, concentrations, or modifications of RTKN protein to suit unique experimental requirements.
Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RTKN.
The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.
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